Hypocholesterolemia of Rhizoma Coptidis alkaloids is related to the bile acid by up-regulated CYP7A1 in hyperlipidemic rats

Cao, Yang; Bei, Weijian; Hu, Yinming; Cao, Le; Hu, Lihua; Wang, Laiyou; Luo, Dan; Chen, Yuanyuan; Yao, Xi; He, Wei; Liu, Xiaobo; Guo, Jiao

doi:10.1016/j.phymed.2012.03.011

Cited by 51 publications

(39 citation statements)

References 20 publications

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“…Rhizoma Coptidis (RC), known as Huang Lian, was officially recognized in the Chinese Pharmacopoeia [4] and has been reported to exert a number of pharmacological actions including antispasmodic [5], anti-Alzheimer's disease [6], hypolipidemic [7], anti-inflammatory [8], antitumor [9], and antibacterial [10]. In addition it was described to ameliorate radiation-induced skin injury [11].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Two Alkaloids after Oral Administration of Rhizoma Coptidis Extract in Normal Rats and Irritable Bowel Syndrome Rats

Gong

Ying

Zhang

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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A comparative pharmacokinetic study of berberine and palmatine after oral administration of Rhizoma Coptidis extract (96 mg/kg, containing berberine 22 mg/kg and palmatine 5 mg/kg based on body weight) was performed in normal and postinflammation irritable bowel syndrome (PI-IBS) rats, induced by intracolonic instillation of acetic acid and restraint stress. Quantification of berberine and palmatine in rat plasma was achieved by using a sensitive and rapid UPLC-MS/MS method. Plasma samples were collected at 13 different time points and the pharmacokinetic parameters were analyzed by WinNonlin software. The significant differences in the pharmacokinetic behaviors, such as C max⁡, AUC(0–t), V d/F, and CL/F, of berberine and palmatine were found between normal and PI-IBS model rats. The results indicated that PI-IBS pathological conditions in rats could alter the pharmacokinetic behavior of drug. Preclinical pharmacokinetic studies are usually carried out on healthy animals. However, we should pay more attention to the fact that the change of pharmacokinetic behavior plays an important role on efficacy. It is essential to investigate the pharmacokinetics of the drug in disease status.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Two Alkaloids after Oral Administration of Rhizoma Coptidis Extract in Normal Rats and Irritable Bowel Syndrome Rats

Gong

Ying

Zhang

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…SREBP-2 regulates the TC level in the body by increasing cholesterol biosynthetic enzymes, including HMGCR [10], whereas CYP7A1 catalyzes the excretion of cholesterol via the digestive tract [12]. In this study, the mature forms of SREBP-2 and HMGCR were increased and CYP7A1 was decreased in the HFD group relative to the levels in the NOR group (p<0.05, Figure 2).…”

Section: Effects Of Korean Rice Cookie On the Regulation Of Hepatic Cmentioning

confidence: 47%

“…The major route for plasma cholesterol elimination is via bile acid secretion. The microsomal cytochrome P450 family 7 subfamily A member 1 (CYP7A1; also known as cytochrome P450 cholesterol 7 alpha-hydroxylase or cytochrome P450 cholesterol 7 alpha-monooxygenase) is the rate-limiting enzyme that catalyzes the conversion of cholesterol into bile acids in the liver [12].…”

Section: Introductionmentioning

confidence: 99%

Rice Cookie Decreases Plasma and Hepatic Lipid Levels in High-Fat Diet-fed Mice: A Comparison Study with Traditional Western Style Cookies

Hong¹,

Woo²,

Song³

2017

JFNR

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The lipid-lowering and antioxidant effects of the traditional Korean rice cookie (KRC), dasik, were compared with those of a western style cookie (WSC) in mice fed a high-fat diet (HFD). The KRC or WSC was supplemented to the HFD as 7% of the total calories. The experimental groups (n = 7) were the normal diet group, HFD group, HFD-KRC group, and HFD-WSC group. The plasma and hepatic triglyceride concentrations of the HFD-KRC group were found to be lower than those of the HFD-WSC group as a result of sterol regulatory element-binding protein 1 and fatty acid synthase expression downregulation, and concomitant peroxisome proliferator-activated receptor-alpha, carnitine palmitoyltransferase 1, and acyl-coenzyme A oxidase 1 expression upregulation (p<0.05). The hepatic reactive oxygen species and peroxynitrite levels were also diminished in the HFD-KRC group of mice, whereas their catalase and glutathione peroxidase protein expression levels were higher than those in the HFD and HFD-WSC groups (p<0.05). In conclusion, the lipid-lowering effects and antioxidant property of the KRC were greater than those of the WSC in mice fed a HFD. Thus, the choice of KRCs as a snack would be preferable to choosing WSCs.

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“…PPARα inhibition dramatically upregulates the expression of HMGCR, followed by an increased cholesterol biogenesis [20]. Cao et al have demonstrated that the cholesterol-lowering effect of coptis alkaloid extract is at least partially attributed to its promoting cholesterol conversion into bile acids by upregulating cholesterol 7α-hydroxylase (Cyp7a1) expression in the liver of hyperlipidemic rats, which is associated with the positive regulation of PPARα [21]. Niemann-Pick C (NPC) 1-Like 1 (NPC1L1) is known to mediate intestinal cholesterol absorption and biliary cholesterol reabsorption.…”

Section: Pparα Regulates Cholesterol Homeostasismentioning

confidence: 99%

Peroxisome Proliferator-Activated Receptor α in Lipid Metabolism and Atherosclerosis

Zheng

Tang

2015

Advances in Clinical Chemistry

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Hypocholesterolemia of Rhizoma Coptidis alkaloids is related to the bile acid by up-regulated CYP7A1 in hyperlipidemic rats

Cited by 51 publications

References 20 publications

Pharmacokinetics of Two Alkaloids after Oral Administration of Rhizoma Coptidis Extract in Normal Rats and Irritable Bowel Syndrome Rats

Pharmacokinetics of Two Alkaloids after Oral Administration of Rhizoma Coptidis Extract in Normal Rats and Irritable Bowel Syndrome Rats

Rice Cookie Decreases Plasma and Hepatic Lipid Levels in High-Fat Diet-fed Mice: A Comparison Study with Traditional Western Style Cookies

Peroxisome Proliferator-Activated Receptor α in Lipid Metabolism and Atherosclerosis

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