Hypocholesterolemic effect of rice protein is due to regulating hepatic cholesterol metabolism in adult rats

Yang, Lin; Chen, Jia-Hou; Xu, Tong; Nie, Minghao; Yang, Hong-Kun

doi:10.1016/j.gene.2012.10.042

Cited by 28 publications

(19 citation statements)

References 40 publications

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“…Temel and others [37] reported that reduced hepatic cholesterol ester content caused an inhibition of cholesterol absorption. Decreased hepatic free cholesterol available after acyl coenzyme A-cholesterol acyltransferase (ACAT) inhibition is very rapidly directed for elimination in bile directly or after conversion to bile acids [38]. The lower hepatic free cholesterol and cholesterol ester storage in the AEERB groups might be the main factor that could effectively inhibit cholesterol absorption.…”

Section: Resultsmentioning

confidence: 99%

Hypolipidemic and Antioxidative Effects of Aqueous Enzymatic Extract from Rice Bran in Rats Fed a High-Fat and -Cholesterol Diet

Wang

Sun

et al. 2014

Nutrients

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Purpose: The aqueous enzymatic extract from rice bran (AEERB) was rich in protein, γ-oryzanol and tocols. The aim of this study was to investigate the effects of AEERB on the regulation of lipid metabolism and the inhibition of oxidative damage. Methods: The antioxidant activity of AEERB in vitro was measured in terms of radical scavenging capacity, ferric reducing ability power (FRAP) and linoleic acid emulsion system-ferric thiocyanate method (FTC). Male Wistar rats were fed with a normal diet and a high-fat and high-cholesterol diet with or without AEERB. After treatment, biochemical assays of serum, liver and feces lipid levels, the antioxidant enzyme activity, malondialdehyde (MDA) and protein carbonyl were determined. Result: AEERB is completely soluble in water and rich in hydrophilic and lipophilic functional ingredients. AEERB scavenged DPPH• and ABTS•+ and exhibited antioxidant activity slightly lower than that of ascorbic acid in the linoleic acid system. The administration of AEERB reduced serum lipid levels and the atherogenic index compared with those of the hyperlipidemic diet group (HD). The administration of AEERB significantly lowered liver lipid levels, inhibited hepatic 3-hydroxyl-3-methylglutaryl CoA reductase activity, and efficiently promoted the fecal excretion of total lipids and total cholesterol (TC) (p < 0.05). Dietary AEERB enhanced antioxidant status in the serum, liver and brain by increasing the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) and decreasing the content of MDA and protein carbonyl. Conclusions: The results indicated that AEERB might act as a potent hypolipidemic and antioxidant functional food.

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Section: Resultsmentioning

confidence: 99%

Hypolipidemic and Antioxidative Effects of Aqueous Enzymatic Extract from Rice Bran in Rats Fed a High-Fat and -Cholesterol Diet

Wang

Sun

et al. 2014

Nutrients

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“…Decreased intestinal lipid absorption is a known mechanism by which plasma lipid levels can be suppressed. It has been reported that various food stuffs such as cabbage, natto, heshiko, and narezushi increase fecal lipid contents, including bile acids (Aoe et al, ; Ashida et al, ; Horiuchi, Kitawaki, Takagi, & Fukuda, ; Hosomi et al, ; Igarashi, Satoh, Numazawa, & Takahashi, ; Takagi et al, ; Tani et al, ; Yang, Chen, Xu, Nie, & Yang, ). As shown in Experiments 1 and 2, the administration of funazushi extract also led to an increase in the fecal contents of triglycerides, cholesterol, and bile acids, in addition to its plasma lipid suppressive effect.…”

Section: Discussionmentioning

confidence: 99%

“…Hypolipidemic effects, including hypocholesterolemic effects, have been studied in various foodstuffs (Kobayashi, Hirahata, Egusa, & Fukuda, ; Takagi et al, ; Uehara et al, ) and their components such as dietary fiber (Aoe, Ohta, & Ayano, ), polyphenols (Ogawa, Hirose, Nagaoka, & Yanase, ; Wang, Shimada, Kato, Kusada, & Nagaoka, ), proteins (Hosomi et al, ; Yang, Chen, Xu, Nie, & Yang, ) and others. In these studies, the hypolipidemic effect are thought to be related to specific actions such as bile acid binding ability (Nagaoka, ; Ogawa et al, ; Wang et al, ), enhancement of bile acid excretion (Ashida, Saito, Kawato, Suginami, & Imayasu, ), and increase in enzyme activity or mRNA expression involved in lipid metabolism (Tani et al, ).…”

Section: Introductionmentioning

confidence: 99%

Hypolipidemic effect of water‐extractive components from funazushi: A fermented product of crucian carp

Itō

2018

J Food Biochem

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To verify minor physiological functions of funazushi and its water‐extractive components (extracts), the hypolipidemic effects of extracts from funazushi, a traditional fermented crucian carp in Japan, were examined. Administration of funazushi extract to rats suppressed the plasma levels of cholesterol and triglycerides and tended to increase the fecal levels of triglycerides, cholesterol, and bile acids (BAs). The addition of funazushi extract to artificial micelles composed of lipids, BAs and distilled water decreased the contents of lipids transported to the aqueous layer, indicating a decrease in the micellar solubility of lipids. This decrease in micellar solubility is thought to be attributable to the binding of certain components in the funazushi extract to the BAs. These results suggest that the hypolipidemic effect of funazushi extract is related to the inhibition of BA activity, leading to suppressed micellar solubility of lipids in the intestine and enhanced lipid excretion. Practical applications The extractive components from fermented foods such as funazushi are thought to have various physiological functions, including decreases in blood lipid levels relating to the inhibition of bile acids, but most of those functions have not been verified scientifically. To promote an application of fermented foods as functional foods, verification of the physiological functions based on scientific evidence is considered to be indispensable.

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“…Rice can exert antioxidant capacity . As a major dietary source of protein for humans, rice protein (RP) has attracted considerable attention for its physiological functions . Recently, a series of in vivo studies demonstrated that RP could significantly reduce hepatic contents of malondialdehyde (MDA) and protein carbonyl (PCO), which were two major biomarkers of oxidative stress, suggesting that the status of depressing lipid peroxidation and protein oxidation was consequent upon attenuating the susceptibility to reactive oxygen species (ROS)‐mediated damage by RP‐feeding .…”

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant activity of rice protein affected by alkaline degree and gastrointestinal protease digestion

Liu

Wang

et al. 2016

J Sci Food Agric

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Hypocholesterolemic effect of rice protein is due to regulating hepatic cholesterol metabolism in adult rats

Cited by 28 publications

References 40 publications

Hypolipidemic and Antioxidative Effects of Aqueous Enzymatic Extract from Rice Bran in Rats Fed a High-Fat and -Cholesterol Diet

Hypolipidemic and Antioxidative Effects of Aqueous Enzymatic Extract from Rice Bran in Rats Fed a High-Fat and -Cholesterol Diet

Hypolipidemic effect of water‐extractive components from funazushi: A fermented product of crucian carp

In vitro antioxidant activity of rice protein affected by alkaline degree and gastrointestinal protease digestion

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