Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay- directed fractionation techniques

Sezik, Ekrem; Aslan, Mustafa; Yeşilada, Erdem; Ito, Shigeru

doi:10.1016/j.lfs.2004.07.024

Cited by 191 publications

(117 citation statements)

References 28 publications

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“…Medicinal plants act with different mechanisms such as increased insulin sensitivity, enhanced glucosedependent insulin secretion, stimulating regeneration of pancreatic islets, reduction of inflammation and oxidative stress in diabetic rats (Sezik et al, 2005). Silymarin by inhibited interleukin 1β and interferon γ, prevents the production on nitric oxide.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Oral Administration of Different Doses of Hydroalcoholic Extract of Silymarin on Status of Serum Trace Elements

Sajedianfard¹,

Nazifi²,

Shamsaei³

2014

American Journal of Animal and Veterinary Sciences

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In this research, the effect of oral administration of different doses of hydroalcoholic extract of silymarin on the status of trace elements with antioxidant properties (Se, Cu, Zn, Mn and Fe) was studied. Fifty male rats were randomly used in five groups including healthy control group (treated by saline), diabetic control group (treated by saline) and three diabetic groups that were daily treated by different oral dose of silymarin (100, 175 and 250 mg kg −1 ). Diabetes was induced by intraperitoneal injection of streptozotocin (50 mg kg −1 ) in rats. Rats were orally treated for 14 days by gavage. Weight was measured before STZ injection, 7 and 14 days after treatment. The blood glucose was measured before injection of STZ, 3 days after injection and 7 and 14 days after diabetes was induced (under treatment by silymarin). At the end of the study, blood samples were taken by heart puncture. Results showed that the average weight increased during the 14 days of treatment with silymarin and the blood glucose was decreased. Hydroalcoholic extract of silymarin increased trace elements levels in treated groups by dose-dependent manner. The present study showed that in diabetic rats, high therapeutic doses of silymarin had a major effect on serum antioxidant factors. Results also showed that hydroalcoholic extract of silymarin increased the body weight and decreased serum glucose concentration at the end of the treatment period. Silymarin in a dose dependent manner could improve trace element levels in diabetic rats. Therefore, it may cause reduction of oxidative stress in the diabetic rats.

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Section: Discussionmentioning

confidence: 99%

The Effects of Oral Administration of Different Doses of Hydroalcoholic Extract of Silymarin on Status of Serum Trace Elements

Sajedianfard¹,

Nazifi²,

Shamsaei³

2014

American Journal of Animal and Veterinary Sciences

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“…The increase in blood glucose level after STZ administration may be due to insulin deficiency (ID) or insulin resistance (IR) in diabetic rats. It was found that NNSE significantly (p<0.05) reduced blood glucose level in diabetic rats, which represents a reversal of insulin resistance or increasing insulin secretion due to the regeneration of damaged pancreatic β-cells in STZ induced diabetic rats [34].…”

Section: Effect Of Nnse On Antioxidant Enzymesmentioning

confidence: 90%

Antidiabetic and Antihyperlipidaemic Activity of Nelumbo Nucifera Gaertn Ethanol Seed Extract in Streptozotocin Induced Diabetic Rats

Bhardwaj

Modi²

2017

Int J Pharm Pharm Sci

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Objective: The main objective of the study was to investigate the effect of ethanol seed extracts of Nelumbo nucifera Gaertn (Nymphaeaceae) as antihyperglycemic, anti-hyperlipidemic and antioxidant activity in streptozotocin-induced diabetic rats.Methods: Diabetes was induced in wistar albino rats by administration of streptozotocin (single intraperitoneal dose of 60 mg/kg B. W). The ethanol extract of N. nucifera seed at a dose of 200 and 400 mg/kg body weight was administrated at a single dose per day to STZ induced diabetic rats for a period of 42 d. The different pharmacological parameters were evaluated. The effect of ethanol seed extract of N. nucifera on insulin, blood glucose, urea, creatinine, HbA1C, serum protein, albumin, globulin, serum enzymes, serum lipid profiles, lipid peroxides (LPO) and other antioxidant enzymes like catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) and reduced glutathione (GSH) were measured in the diabetic rats. Results:In the acute toxicity study ethanol seed extract of Nelumbo nucifera were non-toxic at 2000 mg/kg in rats. The ethanol extract of Nelumbo nucifera seed showed significant reduction in blood glucose (p<0.05), serum enzymes (SGPT, SGOT, ALP) (p<0.05), lipid parameters (TC, TG, VLDL, LDL) (p<0.05) except HDL and significantly increased insulin (p<0.05), HDL (p<0.05), GPx, GSH, SOD and CAT (p<0.05) at the dose of 400 mg/kg when compared with the diabetic-induced control. Conclusion:The present study suggested that the NNSE has significant (p<0.05) antihyperglycemic, antihyperlipidemic and antioxidant activity in STZ induced diabetic rats. These results clearly indicate that Nelumbo nucifera is effective against free radical-mediated diseases, thus replacing the synthetic ones.

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“…It has been reported that flavonoids has a role in regeneration of the injured pancreatic β-cells in diabetic models [25] and thus may prevent insulin resistance. Other study showed inhibitory activity of some flavonoids on cAMP phosphodiesterase activity which is accompanied by insulin secretion which subsequently reduces glucose level [26]. It has been reported that quercetin has antidiabetic effect like metformin [27].…”

Section: Discussionmentioning

confidence: 99%

Effects of Prosopis farcta fruit Hydroalcoholic Extract on Serum Concentrations of Glucose and Lipids in Insulin Resistance Model of Rats

Heydari

Sarir

Ghiasi

et al. 2018

Zahedan J Res Med Sci

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Background and Objective: Prosopis farcta fruit (PFF) is known to have antioxidant activity. Antioxidants can reduce and prevent dyslipidemia and hyperglycemic in diabetic patients. This study was conducted to investigate the effect of PFF hydroalcoholic extract on some blood biochemical parameters in insulin resistance model of rats. Methods: In this experimental study, diabetes was induced by feeding the animals with fructose (12% w/v) and soybean (20% dry matter) for 6 weeks followed by a single intraperitoneal injection of streptozotocin (30 mg/kg). The animals were divided into four groups: 1 and 2) Healthy and diabetic controls; 3 and 4) healthy and diabetic rats receiving PFF (100 mg/kg body weight). The blood samples were collected and the serum concentrations of glucose, triglycerides, cholesterol, HDL-C, LDL-C and VLDL-C were investigated. Results: Streptozotocin increased serum levels of glucose, triglycerides, cholesterol and LDL-C (P < 0.05), but PFF extract lowered the serum concentrations of these variables (P < 0.05) in diabetic rats. Conclusions: PFF extract might be useful for the treatment of hyperglycemic and hyperlipidemic in diabetic patients.

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Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay- directed fractionation techniques

Cited by 191 publications

References 28 publications

The Effects of Oral Administration of Different Doses of Hydroalcoholic Extract of Silymarin on Status of Serum Trace Elements

The Effects of Oral Administration of Different Doses of Hydroalcoholic Extract of Silymarin on Status of Serum Trace Elements

Antidiabetic and Antihyperlipidaemic Activity of Nelumbo Nucifera Gaertn Ethanol Seed Extract in Streptozotocin Induced Diabetic Rats

Effects of Prosopis farcta fruit Hydroalcoholic Extract on Serum Concentrations of Glucose and Lipids in Insulin Resistance Model of Rats

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