Hypoglycemic activity and the activation of phosphorylation of a triterpenoid-rich extract from Euryale shell on streptozotocin-induced diabetic mice

Yuan, Huaibo; Meng, Shaohua; Gong, Zhaobin; Chen, Deyi; Cuan, Zhang

doi:10.3329/bjp.v8i3.14718

Cited by 6 publications

(8 citation statements)

References 21 publications

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“…For instance, thiazolidinediones such as rosiglitazone, may induce edema (Bailey et al 2010), heart failure (DREAM Trail Investigators 2008), and bone loss (Mancini et al 2009). An increasing number of products with anti-diabetic properties have recently been extracted from natural sources (Bae et al 2013;Yuan et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic, Hypolipidemic and Antioxidant Effects of Peptides from Red Deer Antlers in Streptozotocin-Induced Diabetic Mice

Jiang

Zhang

Zhu

et al. 2015

Tohoku J. Exp. Med.

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Diabetes mellitus is a serious chronic metabolic disorder. To develop novel anti-diabetic drugs from nature sources has always been the focus of research. Red deer (Cervus elaphu Linnaeus) antler is one of the most famous Chinese traditional medicines. We found that the peptides of 5-10 kDa from red deer antlers (PRDA) promoted the growth of cultured rat islet cells. The purpose of this study was to investigate the anti-diabetic actions of PRDA in vivo and purify a pure active peptide. We therefore investigated the hypoglycemic, hypolipidemic and antioxidant effects of PRDA in streptozotocin-induced diabetic mice and isolated a pure anti-diabetic peptide. PRDA, given intraperitoneally (75, 150, or 300 μg/kg), significantly decreased the blood glucose levels, significantly increased the insulin concentrations, and remarkably improved the lipid metabolism in the diabetic mice. PRDA significantly increased the superoxide dismutase activity, catalase activity and the total antioxidant capacity in the serum and liver, and simultaneously decreased the malondialdehyde levels. The activities of hexokinase and pyruvate kinase, two important enzymes involved in glucose utilization, were also significantly increased in the liver of the PRDA-treated diabetic mice. Moreover, a novel anti-diabetic peptide isolated from PRDA significantly promoted the viability of cultured rat insulinoma cells. The molecular mass of the purified peptide was 7064.8 Da under mass spectrometry, and its N-terminal amino acid sequence was identified as LSPFTTKTYFPHFDLSHGSA. Thus, PRDA may be useful in managing the hyperglycemia, hyperlipidemia, and oxidative stress in diabetes, and the anti-diabetic peptide is a promising drug for the treatment of diabetes.

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Section: Introductionmentioning

confidence: 99%

Hypoglycemic, Hypolipidemic and Antioxidant Effects of Peptides from Red Deer Antlers in Streptozotocin-Induced Diabetic Mice

Jiang

Zhang

Zhu

et al. 2015

Tohoku J. Exp. Med.

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“…The improvement in HDL was not significant in both middle and high dose groups. 35 The glucose consumption rate of crude polysaccharide, standard and control were 100.4%, 100.4% and 102.4% respectively. Therefore researchers concluded that polysaccharides not only improve uptake of glucose by insulin resistant cells but also induce insulin to reduce blood glucose levels.…”

Section: Antidiabetic Activitymentioning

confidence: 92%

A Critical Review on Ethnobotanical and Pharmacological Aspects of Euryale Ferox Salisb.

Mittal¹,

Sharma²,

Mittal³

2020

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Though now its cultivation is confined only to Bihar along with adjacent states i.e. Assam, Orissa and West Bengal. 5 Optimum atmospheric conditions to grow is tropical and subtropical climate, temperature ranging from 20 o C-35 o C, relative humidity between 50%-90% and rainfall between 100 cm-250 cm. 6 The Euryale ferox is a perineal plant, rooted in the soil with leaves that are broad, round and blade-shaped thus remaining afloat on the surface of pond water. The leaf lamina and vascular bundles have many sharp prickles whereas the rhizomes lie deep in the bottom of the pond with the help of dense fleshy roots. At a time, the plant bears 15-20 spongy fruits, ABSTRACT Introduction: One of the relished dry fruits known by the names of Makhana, Phool Makhana, Gorgon Nut and Fox Nut in the Indian continent, Euryale ferox Salisb. (Nymphaeaceae) is the only plant that belongs to Euryale genus. It is found in abundance in Mithila, Darbhanga and Madhubani region of Bihar state. Since ages, in Ayurveda and Chinese practices, it has been used for the treatment of the renal disorder, chronic diarrhoea, excessive leucorrhea and hepatic dysfunctioning. Its bio-active compounds act as antioxidant, antimicrobial, antiischaemic, anti-diabetic, immunomodulatory, anti-melanogenic, anti-cytotoxic. Methods: The information has been collected from various scientific journals, reviews, books, reports and patent databases. Results: This review summarizes the isolated bioactive compounds in different extracts, patented compounds/formulations with pharmacological activities, present in different parts of Euryale ferox Salisb. Hence, it has been used as a remedy for numerous ailments since long and also proves itself as a panacea for humanity.

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“…Triterpenoids, which are produced from oleanolic acid, are anti-inflamatory and angiogenesis inhibitors (Magdalena Radomska-Leśniewska et al, 2017). The triterpenoid extracted from the Euryale ferox shell has a therapeutic effect on insulin resistance diabetes showing regulated bloodsugar metabolism, lowering the blood sugar of hyperglycemic mice, recovering the pancreatic islet morphology, and increased insulin receptor expression in a dosed manner (Yuan et al, 2014). In vitro, triterpenoid has strong α-glucosidase inhibitory activity by mean of noncompetitive inhibition (Liu et al, 2014).…”

Section: Figure 3 Wound Area In Hyperglycemic Rats Applied With Vario...mentioning

confidence: 99%

Anredera cordifolia leaves extract accelerates the wound healing of normal and hyperglycemic rats

et al. 2022

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Anredera cordifolia ((Madeira vein (English) or Binahong (Indonesia language)) leaves contain ingredients that promote wound healing. This study aims to determine the effect of Madeira vein leaves ethanolic extract (MLE) on normal and hyperglycemic rat wounds. This is an experimental study using male Wistar rats aged 2-3 months, body weight between 250-300 grams induced by a single injection of streptozotocin dose 60 mg/kg BW intraperitoneally. Rats were divided into 8 groups namely normal without MLE, normal with MLE 2.5% w/v, normal with MLE 5% w/v, normal with MLE 10% w/v, hyperglycemia without MLE, hyperglycemia with MLE 2.5% w/v, hyperglycemia with MLE 5% w/v and hyperglycemia with MLE 10% w/v. Punch biopsy was used to create wounds on the skin of rats with a diameter of 8 mm after the blood glucose level measurement was higher than 200 mg/dL. MLE is applied 3 times a day for 14 days on the wounds. Wound contractions occurred in line with the length of treatment days. In normal skin, the area of the wound had decreased by 22% within three days and to 76% at 14 days after wound creation. On the 14th day of treatment, the wound area of hyperglycemic rats decreased > 60%. The largest wound contraction was found when using MLE 10% w/v. Increasing the MLE dose stimulated better wound contraction/healing than control wounds. Wound healing involves many types and products of cells. Starting with hemostasis, wound healing is followed by inflammatory and proliferative phases to form new tissue, angiogenesis, and matrix formation. The MLE content is beneficial for wound healing in normal and hyperglycemic rats. MLE plays a role in accelerating wound healing in normal and hyperglycemic rats. The MLE dose of 10% w/v provides faster wound healing than the 2.5% and 5% w/v doses.

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Hypoglycemic activity and the activation of phosphorylation of a triterpenoid-rich extract from Euryale shell on streptozotocin-induced diabetic mice

Cited by 6 publications

References 21 publications

Hypoglycemic, Hypolipidemic and Antioxidant Effects of Peptides from Red Deer Antlers in Streptozotocin-Induced Diabetic Mice

Hypoglycemic, Hypolipidemic and Antioxidant Effects of Peptides from Red Deer Antlers in Streptozotocin-Induced Diabetic Mice

A Critical Review on Ethnobotanical and Pharmacological Aspects of Euryale Ferox Salisb.

Anredera cordifolia leaves extract accelerates the wound healing of normal and hyperglycemic rats

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