Hypoglycemic activity of aqueous leaf extract of Persea americana Mill

Antia, Bassey S.; Okokon, Jude E.; Okon, Pa

doi:10.4103/0253-7613.16858

Cited by 66 publications

(50 citation statements)

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“…The leaves have been reported to be effective anti-tussive, antidiabetic, anti-arthritic by traditional medicine practitioner of Ibibio tribe of Southern Nigeria. Analgesic properties of the leaves have also been reported (Anita et al, 2005).…”

Section: Introductionmentioning

confidence: 93%

Histopathologic Effect of Persea americana Aqueous Leaves Extract on the Liver and Kidney of Weaner Rabbits (California Species)

Adisa

Ajayi²,

Egbujo

2011

Int. J. Morphol.

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SUMMARY:Persea americana (avocado) is widely grown in parts of Southeastern Nigeria and used as a medicinal plant in the treatment of several ailments by alternative medical practitioners but very little research has been carried out on its pharmacotoxicity. This study therefore intends to study the histopathologic effect(s) of Persea americana aqueous leaf extract on the liver and kidneys of rabbits. Fresh leaves of Persea americana were processed using the Soxhlet extraction to obtain the aqueous extract. Three (3) groups of weaner rabbits namely the control, the recommended dose and the high dose groups were given water, 75mg/kg/ and 150mg/kg per day of the extract respectively for 28 days. The animals were sacrificed, the liver and kidney were harvested, fixed in 10% buffered formol saline, processed into paraffin wax, sectioned at 5µm and stained by the Haematoxylin and Eosin method and Perl's Prussain Blue method. Slightly better weight gain by the experimental groups suggests that the extract enhances appetite. Histopathology of the liver and kidney of the recommended and high dosage groups were not different from the control group suggesting that the plant extract is beneficial except for the observed loose stool, suggesting increased bowel emptying. This however did not affect weight gain.

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Section: Introductionmentioning

confidence: 93%

Histopathologic Effect of Persea americana Aqueous Leaves Extract on the Liver and Kidney of Weaner Rabbits (California Species)

Adisa

Ajayi²,

Egbujo

2011

Int. J. Morphol.

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“…Diabetes was induced in albino rats of either sex by a single intraperitoneal injection of aqueous Alloxan monohydrate (135 mg/kg body weight) (Sigma Chemical Co. USA) 15 . Blood samples were collected before and after the administration of Alloxan to know the status of diabetes.…”

Section: Induction Of Experimental Diabetesmentioning

confidence: 99%

Untitled

2013

IJPSR

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ABSTRACT:The concerned study reveals the first time experimental investigation of Hypoglycemic and antihyperglycemic effect of seed extract of Acacia tortilis plant was in normoglycaemic and Alloxaninduced (135 mg/Kg body weight intraperitoneally) diabetic rats. The seed extract at the dose of 100 and 200 mg/kg body weight was administered orally once a day for 13 days and at the end of the experimentation Oral Glucose Tolerance Test (OGTT) and blood glucose estimation was done in all groups. The extract significantly lowered the blood glucose levels to an extent comparable to that produced by standard Oral hypoglycemic drug (Gliclazide 22 mg/Kg body weight) in both normal and diabetic rats. The results suggest that seed extract of Acacia tortilis possess significant antidiabetic activity. The extract seems promising for the development of a phytomedicine for diabetes mellitus in future prospectus.

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“…The screened plant parts were mango (Mangifera indica L.) leaves [11], avocado (Persea americana Mill.) leaves [12], meniran (Phyllanthus niruri L.) herb [13], Kelor (Moringa oleifera Lam.) leaves [14], ginger (Zingiber officinale Roscoe) rhizome [15], jeringau (Acorus calamus L.) rhizome [16], jamblang (Syzygium cumini (L.) skeels leaves [17], asam jawa (Tamarindus indica L.) seed [18], pare (Momordica charantia L.) fruit [17], and Mimba (Azadirachta indica A. juss) leaves [19] which were given orally at the same doses (300 mg/kg bw) in mice induced glucose.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic Activity of Ten Medicinal Plants Extract in Glucose Induced Mice

Muhtadi

Irenka

Ayu

et al. 2017

Asian J Pharm Clin Res

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Objective: To evaluate and compare the hypoglycemic activity of 10 medicinal plants extract that is used empirically to treat hyperglycemia in Indonesia, to determine plant with the most potential as a hypoglycemic agent.Methods: Activity test was conducted in Swiss Webster glucose-induced mice with glucose tolerance test. The ethanolic extracts of Mangifera indica L. leaves, Persea americana Mill. leaves, Acorus calamus L. rhizome, Phyllanthus niruri L. herb, Syzygium cumini (L.) skeels bark, Zingiber officinale Roscoe rhizome, Moringa oleifera Lam. leaves, Tamarindus indica L. seed, Momordica charantia L. fruits, and Azadirachta indica A. juss leaves, which were given orally at the same dose of 300 mg/kg bw. The blood samples were used for determination of glucose level examination using a glucose meter and test strips (Accu-Chek). Results:The ethanolic extract of M. indica L. leaves has the best activity in reduction of blood glucose level in mice, followed by Z. officinale Roscoe rhizome, A. calamus L. rhizome, T. indica L. seed., M. charantia L. fruit., S. cumini (L.) skeels bark, P. niruri L. herb., P. americana Mill. leaves, and A. indica A. juss leaves. Conclusion:Results of this study suggest the potential use of M. indica L. leaves extract in the therapy of hyperglycemia.

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Hypoglycemic activity of aqueous leaf extract of Persea americana Mill

Cited by 66 publications

References 0 publications

Histopathologic Effect of Persea americana Aqueous Leaves Extract on the Liver and Kidney of Weaner Rabbits (California Species)

Histopathologic Effect of Persea americana Aqueous Leaves Extract on the Liver and Kidney of Weaner Rabbits (California Species)

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Hypoglycemic Activity of Ten Medicinal Plants Extract in Glucose Induced Mice

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