Hypoglycemic activity of Bougainvillea spectabilis stem bark in normal and alloxan-induced diabetic rats

Jawla, Sunil; Kumar, Yogesh; Khan, Msy

doi:10.1016/s2221-1691(12)60337-2

Cited by 19 publications

(18 citation statements)

References 19 publications

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“…Bougainvillea (Bougainvillea glabra Choisy; Nyctaginaceae) is an ornamental flowering plant which having distinguishable medicinal properties. It has a thorny woody, smooth leaves, and which one that is great for produce brilliant color (El-Quesni 2007;Jawla 2012;Joshny 2012). Bougainvillea originated and popular in the tropical and warm climates areas such as South America, Southern California, Florida, and the Caribbean (Schoellhorn and Alfarez 2002).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and toxicity properties of anthocyanin extracted from red flower of four tropical shrubs

et al. 2016

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Abstract. Kuspradini H, Rosiarto AM, Putri AS, Kusuma IW. 2016. Antioxidant and toxicity properties of anthocyanin extracted from red flower of four tropical shrubs. Nusantara . Some of flowers are colored by anthocyanins and make their own shade profile. Anthocyanins are natural colorants which have gained a growing interest due to their extensive range of colors and beneficial health effects. Anthocyanin content, antioxidant and toxicity activity of four red flowers (Bougainvillea glabra, Jatropha integerrima, Melastoma malabathricum and Mussaenda philippica) has been evaluated in this study by pH-differential, DPPH and Brine Shrimp Lethality method, respectively. In this present work, 1% HCl-ethanol and ethanol solvent were used for the extraction. The extractive yield was varied in different extraction system, 5.80 to 13.30% in 1% HCl-ethanol and 6.29 to 8.81% in ethanol solvent. The IC 50 of antioxidant from different extraction systems were also varied, whereas the acidified ethanol extracts showed a highest scavenging activity than the ethanol extracts, 11.67 to 46.38 ppm and 79.08 to 133.35 ppm, respectively. The free radical scavenging action of 1% HCl-ethanol extracts of flower are in the order as J. integerrima > M. malabathricum > M. philippica > B. glabra while in the ethanol extracts are in the order as M. malabathricum > J. integerrima > B. glabra >M. philippica. In the group of 1% HCl-ethanol extracts, Jatropha integerrima Jacq was the richest in anthocyanin content (15.83 mg CGE/100 g DW) and showed the strongest antioxidant activity (11.67 ppm) and not toxic. Therefore, these can be regarded as a potential pigment source for food and natural product applications.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and toxicity properties of anthocyanin extracted from red flower of four tropical shrubs

et al. 2016

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“…In Bangladesh, the plant is widely distributed. The root of the plant possesses hypoglycaemic (Jawla, 2011) and antihyperlipidemic properties (Saikia and Lama, 2011) In this investigation, the methanol extracts of leaves of A. chaplasha and B. spectabillis growing in Bangladesh as well as their organic and aqueous soluble fractions were studied for assessing the antioxidant, cytotoxic, thrombolytic, membrane stabilizing and antimicrobial activities and, we herein, report the results of our preliminary studies for the first time.…”

Section: Introductionmentioning

confidence: 99%

Bioactivities of Artocarpus chaplasha Roxb. and Bougainvillea spectabillis Willd.

et al. 2013

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The methanol extracts of leaf of Artocarpus chaplasha Roxb. and Bougainvillea spectabillis Willd. as well as their petroleum ether, carbon tetrachloride, chloroform and aqueous soluble partitionates were subjected to screenings for antioxidant, cytotoxic, thrombolytic, membrane stabilizing and antimicrobial activities. The antioxidant potential was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and Folin- Ciocalteau reagent using butylated hydroxytolune (BHT) and ascorbic acid as standards. The aqueous soluble fraction of the crude methanol extract of A. chaplasha and the methanolic crude extract of B. spectabillis demonstrated the highest free radical scavenging activity with the IC50 of 15.60±0.27 ?g/ml and 18.33±0.17 ?g/ml, which could be correlated to their total phenolic content of 61.26±0.23 and 50.00±0.19 mg of GAE/gm of extractive, respectively. Different extractives of A. chaplasha and B. spectabillis showed clot lysis activity ranging from 2.56±0.68% to 17.07±0.23% and 2.24±0.71% to 17.59±0.74% as compared to 66.77% and 3.791 % produced by the standard streptokinase and water, respectively. In hypotonic solution and heat induced conditions, the crude extract of A. chaplasha inhibited the haemolysis of human erythrocyte by 41.96±0.87% and 40.00±0.78%, while the carbon tetrachloride soluble fraction of methanol extract of B. spectabillis inhibited haemolysis by 65.68±0.36% and 35.62±0.82%, respectively. Here, acetyl salicylic acid (0.1 mg/ml) was used as reference showing 72.79% and 42.12% of haemolysis of RBCs in hypotonic and heat induced conditions, respectively. Among the extractives of both plants, the crude methanol extract of A. chaplasha and the chloroform soluble fraction of B. spectabillis extract revealed mild to moderate antimicrobial activity with zone of inhibition ranging from with 7.0 to 13.0 mm. The general toxicity was determined by brine shrimp lethality bioassay where the pet-ether soluble fraction of A. chaplasha (LC50 0.781±0.36 ?g/ml) and the aqueous soluble partitionate of B. spectabillis (LC50 1.28±0.57 ?g/ml) suggested the presence of considerable bioactive principles. DOI: http://dx.doi.org/10.3329/bpj.v16i1.14493 Bangladesh Pharmaceutical Journal 16(1): 63-68, 2013

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“…Similar studies were performed with the oral administration of ethanol extracts of flowers from B. spectabilis . Its antidiabetic effect was evaluated using diabetic male Wistar rats induced with alloxan [ 74 ]. The chloroform extract of flowers from B. spectabilis administered intraperitoneally reduced glucose levels in diabetic Swiss mice [ 75 ].…”

Section: Pharmacological Activitymentioning

confidence: 99%

“…spectabilis [ 61 , 76 ]. Studies carried out on the steam bark extract of B. spectabilis orally administered in albino rats showed significant hypoglycaemic activity [ 77 ]. In the case of ethanol extracts of bracts and flowers from B .…”

Section: Pharmacological Activitymentioning

confidence: 99%

Bougainvillea Genus: A Review on Phytochemistry, Pharmacology, and Toxicology

Abarca-Vargas

Petricevich

2018

Evidence-Based Complementary and Alternative Medicine

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This review discusses the current knowledge of the phytochemistry and in vitro and in vivo evaluations carried out using the extracts and, where appropriate, the main active components isolated from the genus Bougainvillea. Out of 18 species, most phytochemical, pharmacological, and toxicological studies focused on four species with different cultivars and one hybrid. Some plants are used for the treatment of various health disorders. Numerous phytochemical investigations of plants in this genus confirm the presence of aliphatic hydrocarbons, fatty acids, fatty alcohols, volatile compounds, phenolic compounds, peltogynoids, flavonoids, phytosterols, terpenes, carbohydrates, and betalains. Various studies have confirmed that these extracts or active substances that were isolated from the genus Bougainvillea have multiple pharmacological activities. Some species of Bougainvillea have emerged as sources of traditional medicine in human health. More studies of the phytochemical, pharmacological, and toxicological properties and their mechanisms of action, safety, and efficacy in all Bougainvillea species, cultivars, and hybrids are advisable for future research.

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Hypoglycemic activity of Bougainvillea spectabilis stem bark in normal and alloxan-induced diabetic rats

Cited by 19 publications

References 19 publications

Antioxidant and toxicity properties of anthocyanin extracted from red flower of four tropical shrubs

Antioxidant and toxicity properties of anthocyanin extracted from red flower of four tropical shrubs

Bioactivities of Artocarpus chaplasha Roxb. and Bougainvillea spectabillis Willd.

Bougainvillea Genus: A Review on Phytochemistry, Pharmacology, and Toxicology

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