Hypoglycemic activity of polysaccharide, with antioxidation, isolated from cultured Cordyceps mycelia

Li, Shao‐Ping; Zhang, Guihong; Zeng, Qingshu; Huang, Zhenchi; Wang, Ying; Dong, Tina Tingxia; Tsim, Karl Wah Keung

doi:10.1016/j.phymed.2005.02.002

Cited by 172 publications

(86 citation statements)

References 28 publications

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“…variety of biological activities, including anti-tumor, antiinflammatory, anti-oxidant, hypoglycemic and immunomodulatory properties (Li et al, 2005;Kuo et al, 2007;Wang et al, 2009;Zhang et al, 2011). However, there are few reports on its anti-fatigue properties.…”

Section: Introductionmentioning

confidence: 99%

Effects of polysaccharides from <i>Cordyceps sinensis</i> mycelium on physical fatigue in mice

Feng

Zhang

Wang

2012

Bangladesh J Pharmacol

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Section: Introductionmentioning

confidence: 99%

Effects of polysaccharides from <i>Cordyceps sinensis</i> mycelium on physical fatigue in mice

Feng

Zhang

Wang

2012

Bangladesh J Pharmacol

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“…sinensis is traditionally used (Wang and Shiao, 2000;Seth et al, 2014) for anti-inflammation (Yang et al, 2011;Wang et al, 2012), antimicrobial activity (Negi et al, 2014;Mamta Mehrotra et al, 2015), antidiabetic (Kiho et al, 1999;Balon et al, 2002;Lo et al, 2004;Li et al, 2006;Zhang et al, 2006;Shi et al, 2009;El Ashry et al, 2012), antitumor activity (Bok et al, 1999;Zhang et al, 2004), antimetastatic (Nakamura et al, 1999), immunomodulatory (Gong et al, 1990), hypocholesterolemia (Koh et al, 2003), and antioxidant activities (Yamaguchi et al, 2000;Li et al, 2002;Dong and Yao, 2007;Wang et al, 2009), and associated diseases such as hepatic diseases (Liu and Shen, 2003) and chronic kidney diseases . Meena et al (2013) reported that laboratory cultured mycelia powder of O. sinensis is safe and non-toxic up to 2g/kg body weight dose.…”

Section: Traditional Usesmentioning

confidence: 99%

Antihyperglycemic activity of Ophiocordyceps sinensis: A Review

Sirisidthi

Kosai

Jiraungkoorskul

2024

IJARe

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Diabetes mellitus, one of the non-communicable diseases, is still the seriously problem due to leading the causes of death in the developed countries. Therefore it is important to identify novel nutraceuticals or drugs for curing or preventing diabetes because the existing synthetic drugs have several limitations. Traditional medicinal plants and medicinal mushrooms are used in the treatment of diabetes mellitus more than century, but only a few of these have proofed their safe and efficacy. Aim of this review article is focused Ophiocordyceps sinensis one of the edible and medicinal mushrooms used for therapeutic effects and antioxidant activities. It contains several kinds of polysaccharides, proteins, nitrogen compounds, fatty acids, phenolic acids, and isoflavones. Many researches have evaluated that these phytochemical substances have the major impact on diabetes mellitus. This review focuses on the antihyperglycemic activity of this mushroom and clears that it has the potential to be considered as a candidate for preparing the new treatment of diabetes mellitus.

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“…The purified polysaccharides were prepared as described previously (Li & Li, 2009;Li et al, 2006). In belief, the concentrated fractions were applied onto a Sephacryl S-300 column equlibrated with 0.2 M NaCl in 10 mM Tris-HCl (pH 8.0).…”

Section: Extraction and Purification Of Polysaccharidesmentioning

confidence: 99%

“…Polysaccharides from Cordyceps sinensis (CSP) have been identified as one of the main bioactive components (Wang et al, 2010;Zhong et al, 2009). Recent studies have demonstrated the multiple pharmacological actions of CSP, including antitumor, antiinflammatory, antioxidant, antifatigue, hypoglycemic, hypolipidemic, liver protective effects and immunomodulatory properties (Kuo et al, 2007;Li & Li, 2009;Li et al, 2006;Wang et al, 2009;Zhong et al, 2009). In our previous studies, CSP has also been proven to have significant antifatigue effects in mice (Yan et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Polysaccharides fromCordyceps sinensismycelium ameliorate exhaustive swimming exercise-induced oxidative stress

Feng

Wang

Yan³

2013

Pharmaceutical Biology

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Context: Cordyceps sinensis (Berk.) Sacc. (Clavicipitaceae) is a famous medicinal fungus (mushroom) in Chinese herbal medicine. Polysaccharides from Cordyceps sinensis (CSP) have been identified as active ingredients responsible for its biological activities. Although many pharmacological actions of CSP have received a great deal of attention, research in this area continues. Objective: The current study was designed to investigate the effects of CSP on exhaustive exercise-induced oxidative stress. Materials and methods: The mice were divided into four groups: control (C), low-dose CSP treated (LC), intermediate-dose CSP treated (IC) and high-dose CSP treated (HC). The treated groups received CSP (100, 200 and 400 mg/kg, ig), while the control group received drinking water for 28 days, followed by being forced to undergo exhaustive swimming exercise, and some biochemical parameters including superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), malondialdehyde (MDA) and 8-hydroxy-2 0 -deoxyguanosine (8-OHdG) were measured using detection kits according to the manufacturers' instructions. Results: Compared with the C group, exhaustive swimming time was significantly prolonged in the LC, IC and HC groups (p50.05); SOD activities in serum, liver and muscle were significantly higher in the IC and HC groups (p50.05); GPx activities in serum, liver and muscle were significantly higher in the LC, IC and HC groups (p50.05); CAT activities in serum, liver and muscle were significantly higher in the HC groups (p50.05); MDA and 8-OHdG levels in serum, liver and muscle were significantly lower in the LC, IC and HC groups (p50.05). Discussion and conclusion: The results obtained herein indicate that CSP could ameliorate exhaustive exercise-induced oxidative stress.

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Hypoglycemic activity of polysaccharide, with antioxidation, isolated from cultured Cordyceps mycelia

Cited by 172 publications

References 28 publications

Effects of polysaccharides from <i>Cordyceps sinensis</i> mycelium on physical fatigue in mice

Effects of polysaccharides from <i>Cordyceps sinensis</i> mycelium on physical fatigue in mice

Antihyperglycemic activity of Ophiocordyceps sinensis: A Review

Polysaccharides fromCordyceps sinensismycelium ameliorate exhaustive swimming exercise-induced oxidative stress

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