Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume

Yin, Peng; Zhao, Shan; Chen, Siyu; Liu, Jieyuan; Shi, Lingling; Wang, Xinjie; Liu, Yujun; Ma, Chao

doi:10.3390/molecules16119764

Cited by 36 publications

(33 citation statements)

References 26 publications

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“…Glipizide, a popular antidiabetic drug, was used to compare the antihyperglycemic efficacy of apigenin in diabetic rats. STZ treatment usually caused a significant reduction of body weight and our findings Science Publications AJPT have supported the earlier published report in this case (Yin et al, 2011). Decreased body weight during diabetes generally occurs due to excessive breakdown of tissue proteins (Bonaldo and Sandri, 2013).…”

Section: Discussionsupporting

confidence: 80%

Apigenin Causes Biochemical Modulation, Glut4 and Cd38 Alterations to Improve Diabetes and to Protect Damages of Some Vital Organs in Experimental Diabetes

Hossain

Ghosh

Satapathy

et al. 2014

American Journal of Pharmacology and Toxicology

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Diabetes mellitus gradually leads to dysfunction and failure of some vital organs specially the eyes, kidneys, pancreas, brain, heart, liver and lungs. The study was aimed to evaluate the antidiabetic potential of apigenin and its mechanistic role in controlling damages of vital tissues in streptozotocin-induced diabetic rats. Streptozotocin-induced diabetic rats were treated with apigenin and glipizide. Various biochemical changes, GLUT4 and CD38 protein expression patterns and histopathological alterations in some vital organs such as liver, kidneys and pancreas were investigated to compare the antidiabetic potentials of those two chemicals and to understand their capability to control the damages of the vital organs during diabetes. Effective control of blood glucose level along with the alteration of hepatic phase I and phase II drug metabolizing enzymes, antioxidant defense enzyme activities and lipid peroxidation level towards their normal values and enhanced GLUT4 translocation and downregulated CD38 expression by apigenin were observed. Apigenin was also found to prevent the deterioration of vital organs during diabetes. In conclusion, apigenin has predominant role in controlling blood glucose level along with the protection of vital organs eventually damaged during diabetes, by minimizing toxicities and associated diabetic complications in streptozotocin-induced diabetic rats and may explore as a potential antidiabetic agent in near future.

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Section: Discussionsupporting

confidence: 80%

Apigenin Causes Biochemical Modulation, Glut4 and Cd38 Alterations to Improve Diabetes and to Protect Damages of Some Vital Organs in Experimental Diabetes

Hossain

Ghosh

Satapathy

et al. 2014

American Journal of Pharmacology and Toxicology

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“…These enzymes are usually found in large quantities in the liver where they play an important role in the metabolism of amino acids (Yin et al, 2011). Due to damage or toxicity to the liver (e.g.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of hypoglycemic and hypolipidemic effects of internal septum of walnut fruit in alloxan-induced diabetic rats

Ghiravani¹,

Hosseini²,

Taheri³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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Background: Todays, the popularity of herbal medicine is increasing worldwide. Due to importance the evaluation of medicinal herbs efficacy and safety, the present study was conducted to investigate the antidiabetic and hypolipidemic effects of internal septum of walnut fruit (ISWF) ethanolic extract in diabetic rats. Materials and methods: Alloxan diabetic rats treated orally with ethanolic extract of ISWF (0-400mg/kg) for 28 days. To evaluate its anti-diabetic activity, the animals fasting blood glucose were determined on the first, 14 th and 29 th days. Moreover, oral glucose tolerance test (OGTT) was performed in diabetic rats at the last day of the study. After 24h of last administration, the blood samples were collected, and the Plasma lipids and liver enzymes levels were measured in fasting overnight rats. Results: The extract significantly decreased blood glucose (p<0.001) on 14 th and 29 th days. In addition, OGTT revealed that the hypoglycemic effect of the extract appeared at 90 minutes. Alanine aminotransferase and aspartate aminotransferase levels significantly decreased in diabetic rats treated with the both doses (p<0.05). Both doses of the extract were able to decrease triglyceride significantly (p<0.05) in treated diabetic rats, while only the lower dose of the extract (200 mg/kg) attenuate the total cholesterol and low density lipoprotein (p<0.001). Conclusion: These finding support the notion that ISWF is able to reduce hyperglycemia and hyperlipidemia risk in diabetic rats. Key words:Juglans regia, internal septum, walnut fruit, Antidiabetic, Lipid profile IntroductionDiabetes mellitus is a chronic metabolic disease characterized by hyperglycemia due to the impaired secretion and/or action of insulin (Chikhi et al., 2014). Its prevalence is increasing in many populations all over the world. In 2011, there were 366 million cases with diabetes, and it is expected to increase up to 522 million by 2030(Whiting et al., 2011. Hyperglycemia leads to alteration in metabolism of carbohydrate, protein and fat (Wan et al., 2013). This condition results in long term pathogenic disorders such as neuropathy, retinopathy and nephropathy and consequently lowering in life quality (Santaguida et al., 2005). Currently, multiple pharmacological interventions including sulphonylureas, biguanides, alpha-glucosidase inhibitors, thiazolidinediones and/or insulin are applied for the treatment of diabetes (Grossman et al., 2013). However, all of these medications have limited efficacy and result in various side effects such as gastrointestinal upset, weight changes, hypoglycemia, joint stiffness, kidney and skin complications (Nathan, 2007;Soccio et al., 2014).Complementary and alternative medicine has been often used for treatment of diabetes. The most widely used therapies in diabetic populations are nutritional supplements and herbal; people with diabetes use these therapies concurrently with conventional health care services (Chang et al., 2007).The fruit of Juglans regia L (family; Juglandaceae) is a valu...

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“…[21] The antidiabetic activity of tannins was evaluated with porcupine pancreatic amylase, and the inhibitory effect of the alcoholic extracts was found to be comparable with the antidiabetic drug, aracbose. [22] The antihyperglycemic effect was attributed to the ability of tannins to inhibit the alpha-amylase and to bind to carbohydrates leading to the formation of complexes that cannot be absorbed.…”

Section: Discussionmentioning

confidence: 99%

Antihyperglycemic effects of Cajanus cajan L. (pigeon pea) ethanolic extract on the blood glucose levels of ICR mice (Mus musculus L.)

Manzo¹,

Vitor²

2017

Natl J Physiol Pharm Pharmacol

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Background: Diabetes mellitus is a metabolic disease that is usually associated with abnormalities in the metabolism of different substrates leading to high blood glucose levels (BGL). Aims and Objectives: Aims and objectives are to evaluate the effects of ethanolic extracts of Cajanus cajan (CCEE) leaves on its antihyperglycemic effects on BGL of normoglycemic mice. Materials and Methods: 45, 5-week-old female, mice were divided into five groups and were administered with either double distilled water, glimepiride, or CCEE. Results: Baseline BGLs were measured before the induction of hyperglycemia by glucose loading. 30 min after, the BGLs were measured again and ranged between 167.667 and 185.778 mg/dL. Immediately after the hyperglycemic BGLs were measured, the corresponding treatments were administered. Subsequently, three blood collections were done spanning 3 h with 1 h interval. The treatment doses were observed to have a faster onset than the positive control supported by the fact that the treatment groups had significant differences (P < 0.05) with their respective hyperglycemic BGLs on the 1 st h, while the positive control group exhibited significant difference with its hyperglycemic BGL on the 2 nd h. The hypoglycemic effect of the positive control peaked at the 3 rd h with 67.33 mg/dL and surpassed the hypoglycemic effect of the medium-and high-dose groups with 83.778 and 98.556 mg/dL, respectively. The low-dose group did not have significant difference with the negative control group past the 1 st h suggesting that this dosage has a weak hypoglycemic effect. Conclusion: These results indicate that the CCEE leaves were able to produce hypoglycemic effects at doses between 400 and 800 mg/kg bodyweight.

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Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume

Cited by 36 publications

References 26 publications

Apigenin Causes Biochemical Modulation, Glut4 and Cd38 Alterations to Improve Diabetes and to Protect Damages of Some Vital Organs in Experimental Diabetes

Apigenin Causes Biochemical Modulation, Glut4 and Cd38 Alterations to Improve Diabetes and to Protect Damages of Some Vital Organs in Experimental Diabetes

Evaluation of hypoglycemic and hypolipidemic effects of internal septum of walnut fruit in alloxan-induced diabetic rats

Antihyperglycemic effects of Cajanus cajan L. (pigeon pea) ethanolic extract on the blood glucose levels of ICR mice (Mus musculus L.)

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