Hypoglycemic Effect of <i>Moringa oleifera</i> Aqueous Extract in Diabetic Animal Studies: A Mechanisms Review

Pradana, Dhigna Luthfiyani Citra; Rahmi, Eldiza Puji; Muti, Annisa Farida

doi:10.2991/ahsr.k.210115.117

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…This might indicate that Moringa has an insulin-like impact on peripheral tissues, either by boosting glucose uptake and metabolism or by inhibiting gluconeogenesis. It is likely that the aqueous extract of the moringa leaves has some effect of increasing the tissue utilization of glucose (Gray et al, 2000, Oyedepo et al, 2013 by inhibiting hepatic gluconeogenesis or absorption of glucose into the muscles and adipose tissues (Pradana, et al, 2021). However, Ahemen et al (2013) reported insignificant influence of diet containing MOL on glucose in rabbit serum.…”

Section: Results and Discussion I-the Effect Of Moringa Olifera Leavesmentioning

confidence: 99%

Effect of Moringa Olifera Leaves and Seeds Supplementation on Semen Characteristics, Testes and Epididymis Biometry and Some Blood Paramaters in Barki Rams.

Fathy

Nebar

Ahmed

et al. 2022

Menoufia Journal of Animal Poultry and Fish Production

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This study aimed to investigate the effect of MOl or MSC supplementation on some blood constituents, semen characteristics, testis and epididymis measurements in Barki rams. Fifteen Barki rams aged 10-12 months divided into three similar groups (5each). Rams in G1 were fed the basal diet supplemented by MOL (5% of CFM), rams in G2 fed the basal diet supplemented by MSC (10% of CFM) while rams in G3 (control) were fed the basal diet without supplements. Blood samples were collected and erythrocytes, Hb, PLT, PCV, MCV, MCH, MCHC, ALT, AST, glucose, uric acid, creatinine and testosterone were determined. Semen was collected and semen physical characteristics as well as of the epididymis and testes biometric were evaluated. Results indicated that MOL and MSC supplementation to ram rations significantly affected glucose, creatinine, urea, ALT, AST and testosterone levels, and insignificantly on erythrocyte, Hb, PLT, PCV, MCV, MCH, and MCHC. In this regard, MOL supplementation to ram rations increased MCV, PLT and decreased RBCs, Hg, MCH, MCHC, and PCV; while, MSC supplementation increased RBCs, Hg, MCHC, PLT, and urea. The addition of MOL or MSC increased ALT, AST, and creatinine, and decreased testosterone and glucose levels. Both supplementation (MOL or MSC) in Barki rams' feed improved most characteristics of semen such as volume, motility, vitality and normality, and reduced mortality and abnormalities and there is no significant effect on testes measurements. The highest testicular weight and width were observed in the MOL group. The testicular size was relatively higher for rams fed a moringa-free diet compared to those supplemented with MOL or MSC. It could be concluded that supplementation of MOL and MSC rations into Barki rams' rations improved most of the semen characteristics (volume, motility, vitality and normality) and reduced mortality and malformations. However, it negatively affects kidney function (increased urea and creatinine) and liver enzyme activities (ALT & AST).

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Section: Results and Discussion I-the Effect Of Moringa Olifera Leavesmentioning

confidence: 99%

Effect of Moringa Olifera Leaves and Seeds Supplementation on Semen Characteristics, Testes and Epididymis Biometry and Some Blood Paramaters in Barki Rams.

Fathy

Nebar

Ahmed

et al. 2022

Menoufia Journal of Animal Poultry and Fish Production

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“…Moringa oleifera (Moringa) is native to India and is used in many areas of human life due to the macro and microelements it contains [1][2][3]. It is known that Moringa has a hypoglycemic influence [4] and the water extract of its leaves may be used for Diabetes mellitus to reduce the blood glucose level [5]. It was shown that the extract of the Moringa leaves inhibits intestinal α-glucosidase, pancreatic cholesterol esterase, and pancreatic lipase activities, thus helping in the treatment of diabetes mellitus [6].…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic and hypolipidemic activity of moringa grown in hydroponics and soil in Ararat Valley

Tadevosyan,

Hakobjanyan,

Tovmasyan

et al. 2023

FFHD

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Background: Moringa has a hypoglycemic and hypolipidemic influence, and the water extract of its leaves can decrease the amount of glucose during Diabetes Mellitus. Moringa leaves in extract or powder form influenced type I and type II diabetes by enhancing insulin secretion and improving glycogen synthesis and glucose uptake in the liver and muscles. This occurred in the case of type I diabetes, as well as by inhibiting glucose uptake and slowing gastric emptying in the case of type II diabetes.Objective: In our study, we try to evaluate the hypoglycemic, hypolipidemic, and antistress activity of Moringa grown for the first time in Armenia in hydroponic and soil conditions to find out the beneficial cultivation method of Moringa from the point of view of these activities.Materials and Methods: The study was done with the usage of a rabbit model, using water extract of Moringa leaves made with a 150 mg count of leaves on 1 kg weight of the animal. Hyperglycemia in the rabbits was induced by 21-day immobilization stress (3 hours a day). Rabbits were divided into 4 groups: the first group was treated with the extract from the hydroponic Moringa in a dose of 2 ml/day, the second group received the extract from the soil Moringain a dose of 2 ml/day, the third group was the control—which did not receive any extract, but was exposed to stress, like first and second groups— and the fourth group was the norm, which did not receive any extract and was stress free. Each group included 3 animals as means of replication. The glycogen level was measured in the livers, hearts, and muscles of rabbits. The level of glucose, total cholesterol, HDL, and LDL were measured in the serum of animals.Results: Our results showed that after a 21-day period of stress, the increased level of glucose stays at a high level in control groups, while the use of a hydroponic Moringa extract developed stress tolerance in animals and in soil Moringa extract stabilizes glucose levels in the blood. The cholesterol exceeded the norm 1.8 times in the control group and was inferior in hydroponic and soil groups by 1.5 and 1.4 times, respectively. These changes reflect the amount of HDL and LDL. Under stress conditions, the quantity of glycogen decreased from the norm in the liver, muscles, and heart muscle in the control group (2.5; 2.4; and 2.4 times, respectively) and increased in hydroponic (1.6; 1.5; and 2.1 times, respectively) and soil (1.6; 1.5; and 2.4 times, respectively) groups. This evidence shows that under stress conditions the glucose level of blood is improved on the 21st day of stress in groups that received the extract of moringa because of glucose exchange to glycogen with high efficiency in different organs.Keywords: antistress activity, diabetes, HDL, glucose, Moringa oleifera, total cholesterol

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Hypoglycemic Effect of Moringa oleifera Aqueous Extract in Diabetic Animal Studies: A Mechanisms Review

Cited by 2 publications

References 17 publications

Effect of Moringa Olifera Leaves and Seeds Supplementation on Semen Characteristics, Testes and Epididymis Biometry and Some Blood Paramaters in Barki Rams.

Effect of Moringa Olifera Leaves and Seeds Supplementation on Semen Characteristics, Testes and Epididymis Biometry and Some Blood Paramaters in Barki Rams.

Hypoglycemic and hypolipidemic activity of moringa grown in hydroponics and soil in Ararat Valley

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