Hypoglycemic effect of white (Morus alba L.) and black (Morus nigra L.) mulberry fruits in diabetic rat

Abstract

KEYWORDSThe aim of the present study was to investigate the hypoglycemic effect of white (Morus alba L.) and black (Morus nigra L.) mulberry fruits either used individually or in a combination on alloxan diabetic rats. These fruits are reported to be rich in antioxidants, flavonoids and phenolics that can potentially fight against diabetes mellitus. Male albino rats were divided into 5 groups: normal control, alloxan-diabetic control, diabetic rats treated with white mulberry fruit powder at 5% in the diet, diabetic rats treated with black mulberry fruit powder at 5% in the diet and diabetic rats treated with mixture of white and black mulberry fruits powder at 5% in the diet. After 4 weeks of treatment, blood glucose level, liver and kidney enzymes activity, lipid profile, lipid peroxidation and histopathological studies on liver, kidney and pancreas were evaluated. The mixture of white and black mulberry fruits showed the most significant (p < 0.05) improvement in feed efficiency ratio with increasing body weight gain, as well as decrease in blood glucose level and liver-kidney dysfunction when compared with diabetic control rats. Significant decrease in serum cholesterol, triglycerides and low density lipoprotein cholesterol (LDLc) as well as significant increase in high density lipoprotein cholesterol (HDLc) in diabetic rats was observed with all treatments. Moreover, mulberry fruits administration caused significant inhibition in lipid peroxidation and α-amylase activity. In addition, the beneficial effect of all treatments was further confirmed with histopathological examination of liver, kidney and pancreas. This study reveals hypoglycemic and hypolipidemic effects of white and black mulberry fruits either used individually or in combination as a dietary supplement in alloxan diabetic rats. Alloxan Antidiabetic Hypoglycemic Morus alba fruits Morus nigra fruits Lipid peroxidation

Middle East Medicinal Plants in the Treatment of Diabetes: A Review

“…In alloxan diabetic rats, treatment with either M. alba or M. nigra fruit extracts decreased the hyperglycemia significantly, almost to the normal level. The same effect was reported earlier in streptozocin diabetic mice [ 44 ].…”

Phytochemical constituents, hypoglycemic and haematological effects of methanolic Acalypha wilkesiana leaves extract on streptozotocin-induced diabetic rats

“…It is clear that ALT and AST increased significantly from 26 and 34 IU/L in non-diabetic rats to 49 and 63 IU/L, respectively in diabetic control rats (Table 3). Such a significant increase of ALT and AST activities as shown suggest the possible necrotic injury of the liver or cholestasis with hepatocellular necrosis [35]. Data in Table 3 clearly indicate no significance differences between normal and treated rats with the methanolic leaves extract of A. wilkesiana at both doses 20 and 40 mg/100 g b. wt.…”

Synergistic Hepatoprotective and Antioxidant Effect of Artichoke, Fig, Blackberry Herbal Mixture on HepG2 Cells and Their Metabolic Profiling Using NMR Coupled with Chemometrics

“…From the previously displayed data, it can be concluded that phenolic acids, flavonoids, and their derivatives are the major functional substances predominating in artichoke, fig, blackberry, and undoubtedly in their mixture, which was also supported by the NMR profiling where certain signals appear in the aromatic regions as illustrated in the NMR spectra (Figures S2 – S4 ), however, they are less intense than that of primary metabolites as expected in any extract. Nevertheless, secondary metabolites exert their effect in much smaller quantities relative to primary metabolites and play a significant role as phytopharmaceuticals . A scheme representing the major metabolites existing in Egyptian artichoke, fig, blackberry, and consequently their mixture is illustrated in Figure .…”

“…Nevertheless, secondary metabolites exert their effect in much smaller quantities relative to primary metabolites and play a significant role as phytopharmaceuticals. [26] A scheme representing the major metabolites existing in Egyptian artichoke, fig, blackberry, and consequently their mixture is illustrated in Figure 4.…”