Hypoglycemic Effects of a Phenolic Acid Fraction of Rice Bran and Ferulic Acid in C57BL/KsJ-<i>db/db</i>Mice

Jung, Eun Hee; Kim, Sung Ran; Hwang, In Kyeong; Ha, Tae Youl

doi:10.1021/jf0714463

Cited by 244 publications

(160 citation statements)

References 29 publications

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“…Previous studies of FA treatment describe reduced blood glucose levels (Jung et al, 2007) and weakened lipid peroxide by increasing the antioxidant capacity (Sri Balasubashini et al, 2003). These effects may be a suppression of the ROS by FA treatments.…”

Section: Discussionmentioning

confidence: 93%

“…Previous studies reported that FA is an antioxidant that neutralizes free radicals such as superoxide, nitric oxide and hydroxyl radicals that may cause oxidative damage to cell membranes and DNA (Kanski et al, 2002;Ha et al, 2008). FA provides meaningful synergistic protection against oxidative stress in the skin and should protect against photoaging and skin cancer (Lin et al, 2005), hypoglycemic and hypolipidemic effects (Sri Balasubashini et al, 2003;Ohnishi et al, 2004;Jung et al, 2007), hypotensive effects (Suzuki et al, 2002), and anti-inflammatory effects (Yagi and Ohishi, 1979).…”

Section: Introductionmentioning

confidence: 99%

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Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes

et al. 2011

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Diabetic nephropathy is the most serious complication in diabetes mellitus. It is known that oxidative stress and inflammation play a central role in the development of diabetic nephropathy. In this study, we investigated that ferulic acid (FA) known as anti-oxidative agent could effect on diabetic nephropathy by anti-oxidative and anti-inflammatory mechanism. We examined the effects of FA in obese diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats and non-diabetic control Long-Evans Tokushima Otsuka (LETO) rats. We treated FA to experimental rats from 26 to 45 weeks of age. We evaluated ACR, MDA and MCP-1 in 24 h urine and examined renal histopathology and morphologic change in extracted kidneys from rats. Also, we evaluated the ROS production and MCP-1 levels in cultured podocyte after FA treatment. In the FA-treated OLETF rats, blood glucose was significantly decreased and serum adiponectin levels were increased. Urinary ACR was significantly reduced in FA-treated OLETF rats compared with diabetic OLETF rats. In renal histopathology, FA-treated OLETF rats showed decreased glomerular basement membrane thickness, glomerular volume, and mesangial matrix expansion. FA treatment decreased oxidative stress markers and MCP-1 levels in 24 h urine of rats and supernatants of cultured podocyte. In conclusion, it was suggested that FA have protective and therapeutic effects on diabetic nephropathy by reducing oxidative stress and inflammation.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes

et al. 2011

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“…Further study is needed to clarify the exact molecular mechanisms underlying the interaction of ferulate and PI3K/Akt/FOXO3a in aged rats. Ferulate has been reported to increase plasma insulin levels in a model of db/db mice (Jung et al 2007). Different results might come from different circumstances, or pathogenic and normal models.…”

Section: Discussionmentioning

confidence: 99%

Attenuation of age-related changes in FOXO3a activity and the PI3K/Akt pathway by short-term feeding of ferulate

Choi

Kim

Lee

et al. 2011

AGE

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Ferulate (4-hydroxy-3-methoxycinnamic acid) is a well-known phenolic compound that scavenges free radicals and exerts anti-inflammatory effects. Forkhead box O3a (FOXO3a), a transcription factor that plays important roles in aging processes, decreases with age and is negatively regulated through phosphorylation by phosphatidylinositol 3-kinase (PI3K)/Akt signaling. The present study investigated the efficacy of short-term ferulate feeding on age-related changes in PI3K/Akt/FOXO3a and upstream insulin signaling pathways in aged rats. In addition, changes in manganese superoxide dismutase (MnSOD) and catalase expression were examined because of their dependence on PI3K/Akt/FOXO3a activity. Short-term feeding experiments were done with a diet containing ferulate that was given to aged rats at doses of 3 or 6 mg kg −1 day −1 for 10 days.Results showed that FOXO3a activity was increased in the ferulate-fed old group compared with the control old group. Also, ferulate suppressed the PI3K/Akt signaling pathway that is responsible for FOXO3a inhibition in aged rats. Plasma insulin levels and the upstream insulin signaling pathway were also modulated by ferulate correspondingly with PI3K/ Akt/FOXO3a activity. The age-related decrease in two major antioxidant enzymes, MnSOD and catalase, was blunted by ferulate, which was accompanied by FOXO3a transcriptional activity. The significance of the present study is the finding that short-term feeding of ferulate effectively modulates age-related renal FOXO3a, PI3K/Akt and insulin signaling pathways, and MnSOD and catalase expression, all of which may be beneficial for attenuating the aging process.

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“…In a study performed by Ohnishi et al (2004) with KK-Ay mice, the dose of 0.05% FA effectively suppressed blood glucose levels and reduced lipid peroxidation in adipose tissue, indicating that FA may be useful in the reduction of oxidative stress and hyperglycemia in individuals suffering from DM. Subsequently, Jung et al (2007) demonstrated in studies using diabetic mice that FA increases the activity of the enzyme glucokinase, a key enzyme in the regulation of blood glucose levels. Adisakwattana et al (2009) investigated the inhibitory activity of cinnamic acid derivatives against rat intestinal α-glucosidase and porcine pancreatic α-amylase in vitro in order to find effective inhibitors from natural sources that could be used in prevention and treatment of DM.…”

Section: Anti-diabetic Agentmentioning

confidence: 99%

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Brenelli

Goldbeck

Santos

et al. 2013

Braz. J. Pharm. Sci.

162

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Ferulic acid is a phenolic acid widely distributed in the plant kingdom. It presents a wide range of potential therapeutic effects useful in the treatments of cancer, diabetes, lung and cardiovascular diseases, as well as hepatic, neuro and photoprotective effects and antimicrobial and anti-inflammatory activities. Overall, the pharmaceutical potential of ferulic acid can be attributed to its ability to scavenge free radicals. However, recent studies have revealed that ferulic acid presents pharmacological properties beyond those related to its antioxidant activity, such as the ability to competitively inhibit HMG-CoA reductase and activate glucokinase, contributing to reduce hypercholesterolemia and hyperglycemia, respectively. The present review addresses ferulic acid dietary sources, the pharmacokinetic profile, antioxidant action mechanisms and therapeutic effects in the treatment and prevention of various diseases, in order to provide a basis for understanding its mechanisms of action as well as its pharmaceutical potential.Uniterms: Ferulic acid/properties. Ferulic acid/antioxidant activity. Ferulic acid/dietary sources. Ferulic acid/therapeutic effects. Natural products. Pharmacognosy.O ácido ferúlico é um ácido fenólico amplamente distribuído no reino vegetal. Ele apresenta uma ampla gama de potenciais efeitos terapêuticos utéis no tratamento do câncer, diabetes, doenças pulmonares e cardiovasculares, bem como efeitos hepáticos, neuro e fotoprotetores, atividades antimicrobianas e antiinflamatórias. O potencial farmacêutico do ácido ferúlico pode ser atribuído à sua capacidade em sequestrar radicais livres. No entanto, estudos recentes revelaram que o ácido ferúlico apresenta propriedades farmacológicas, além da sua atividade antioxidante, como a capacidade de inibir competitivamente a HMG-CoA redutase e ativar a glucoquinase, contribuindo para reduzir a hipercolesterolemia e hiperglicemia, respectivamente. A presente revisão aborda as fontes dietéticas de ácido ferúlico, o perfil farmacocinético, os mecanismos de ação como antioxidante e efeitos terapêuticos no tratamento e prevenção de várias doenças, de modo a proporcionar uma base para a compreensão dos seus mecanismos de ação, bem como os seus potenciais farmacêuticos.Unitermos: Ácido ferúlico/propriedades. Ácido ferúlico/atividade antioxidante. Ácido ferúlico/fontes dietéticas. Ácido ferúlico/efeitos terapêuticos. Produtos naturais. Farmacognosia. INTRODUCTIONNatural antioxidants exhibit therapeutic potential for a variety of diseases such as cancer, diabetes, and cardiovascular and neurodegenerative diseases (Kayahara et al., 1999;Kim et al., 2003;Soobrattee et al., 2005) where free radicals play a key role in development (Prior et al., 1998). Recently there has been increased public and scientific interest in employing natural antioxidants instead of synthetic antioxidants, due to their potential adverse effects on health which may include carcinogenicity (Ito et al., 1983;Würtzen, 1990;Osawa et al., 1990).Antioxidants found in vegetables can ac...

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Hypoglycemic Effects of a Phenolic Acid Fraction of Rice Bran and Ferulic Acid in C57BL/KsJ-db/dbMice

Cited by 244 publications

References 29 publications

Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes

Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes

Attenuation of age-related changes in FOXO3a activity and the PI3K/Akt pathway by short-term feeding of ferulate

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

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