Hypokalemia in Diabetes Mellitus Setting

Coregliano-Ring, Lucas; Goia-Nishide, Kleber; Rangel, Érika B.

doi:10.3390/medicina58030431

Cited by 24 publications

(42 citation statements)

References 43 publications

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“…The increase in the level of Na + in the group treated with Pterocarpus erinaceus (100 mg/kg, 200 mg/kg, 400 mg/kg) is an indication that the extract may have the ability to improve insulin secretion and uptake in diabetic rats drives glucose and water into the cells, thereby reducing dehydration, reverses the initial direction of water movement and results in an increment of serum sodium levels [49]. On the other hand further decrease in K + observed with the groups treated with Pterocarpus erinaceus stem bark (100 mg/kg, 200 mg/kg, 400 mg/kg ) may be due to redistribution of potassium K+ from the extracellular to the intracellular fluid compartment which happens when insulin is utilized by cells [50]. This is an indication that Pterocarpus erinaceus stem bark aqueous extract may have the ability to improve insulin secretion and glucose uptake in diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Potential of Pterocarpus erinaceus Aqueous Stem Bark Extract to Prevent Oxidative Kidney Damage in Diabetic Rats

Nzute

Ijeomah

Ajiboso

et al. 2023

AJRB

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Diabetes is a chronic, metabolic disease characterized by elevated levels of blood glucose, which over time leads to serious damage to the heart, blood vessels, eyes, kidneys and nerves. This present study investigated the potential of Pterocarpus erinaceus aqueous stem bark extract to prevent oxidative kidney damage in diabetic rats. Thirty six (36) male wistar rats of 100 to 200g were used. The rats were divided into six groups (A-F). Diabetes mellitus was induced in groups B-F by injecting alloxan at the dose of 150 mg/kg body weight. After 72hours, diabetes was confirmed. Vitamin C 25 mg/kg b.wt was used as standard treatment for group C and aqueous extract of Pterocarpus erinaceus stem bark at doses of 100, 200 and 400 mg/kg b.wt were administered to groups D, E and F respectively. All treatments were given orally, daily for 14 days. Phytochemical screening of the extract, Blood glucose level and oral glucose tolerance test were determined. At the end of the experiment, the serum, kidney tissue and kidney homogenate were obtained for the determination of kidney function parameters, histology, lipid peroxidation, antioxidant and inflammation markers. Phytochemical results shows the presence of phenols, tannins, saponins, alkaloids, glycosides, cardiac glycosides and flavonoides. Diabetic rats administered with Pterocarpus erinaceus aqueous stem bark extract showed significant (P<0.05) decrease in, blood glucose, creatinine, blood urea nitrogen (BUN), potassium, MDA, TNF-alpha, IL-6 and TGF-β when compared with diabetic control rats. Also a non significant (P>0.05) decrease in uric acid, albumin, and an increase in sodium, GSH when compared with the diabetic control group. A significant (P<0.05) increase was observed in SOD, CAT, GPx, and GST when compared with diabetic control rats. The kidney histology shows well protected kidney. These results obtained shows that aqueous extract of Pterocarpus erinaceus stem bark exhibited significant antihyperglycemic, improvement in kidney function, antioxidant and anti inflammatory markers and prevented kidney tissue damage in alloxan-induced diabetic rats. This might be useful in the management diabetes mellitus patients.

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Section: Discussionmentioning

confidence: 99%

Potential of Pterocarpus erinaceus Aqueous Stem Bark Extract to Prevent Oxidative Kidney Damage in Diabetic Rats

Nzute

Ijeomah

Ajiboso

et al. 2023

AJRB

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“…Clinical features of hypokalemia include cardiac arrhythmias, muscle paralysis, myopathy, ileus, and rhabdomyolysis. Our patient had features of rhabdomyolysis; renal loss of potassium along with magnesium deficiency contributed to hypokalemia [ 4 ]. Hypokalemia with concomitant hypomagnesemia as described above will be refractory to correction until the magnesium is corrected.…”

Section: Discussionmentioning

confidence: 99%

Multiple Dyselectrolytemia in a Chronic Alcohol Abuser: A Case Report

Sundaram¹,

Madesh²,

Reddy³

et al. 2023

Cureus

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Electrolyte disorders in alcohol-dependent patients can be due to a multitude of reasons. We discuss a patient with diabetes mellitus, seizure disorder, and alcoholism who presented with seizure episodes and vomiting following a binge alcohol intake. The evaluation showed life-threatening metabolic derangements that included hyponatremia, hypokalemia, hypomagnesemia, hypocalcemia, hypochloremia, hypophosphatemia with elevated blood glucose, and metabolic alkalosis with a normal anion gap. Subsequently, a detailed urinary analysis revealed a urinary loss of electrolytes. We emphasize that alcoholinduced tubular injury is a possibility when such a clinical presentation is seen in the emergency room. The complex interplay of various electrolytes in homeostasis posed a great challenge in the management of this patient. Our case reiterates this intricate electrolyte correction policy.

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“…Almost half (46.2%) of deaths at the age of 20-79 years are caused by DM. (Coregliano-Ring et al, 2022;International Diabetes Federation, 2019;Linkeviciute-Ulinskiene et al, 2020;Wolde, 2021). DM disease will impact the quality of life and significantly increase health costs (Akena et al, 2015;.…”

Section: Introductionmentioning

confidence: 99%

Foot Exercise to Overcome Type 2 Diabetes Mellitus: A literature Review

Zakiudin¹,

Irianto

Badrujamaludin

et al. 2022

IJNI

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Prediction in 2030, the number of deaths due to Diabetes Mellitus (DM) will increase and become the seventh cause of death. The role of patients in managing DM is vital because DM is a chronic disease that will suffer for life. Foot exercise is one type of exercise to apply to DM patients. Diabetic foot exercise improves blood circulation and foot sensitivity. This study aims to inform readers about the effectiveness of foot exercise in overcoming DM type 2. This study is qualitative with a literature review. The analysis used inductive content to identify the main themes in the related literature. This article explores the indexed national and international journals of Scopus, Sinta, and Copernicus. There is an effect of diabetes mellitus foot exercise on improving the quality of life of patients with type 2 diabetes. Foot exercise provides comfort, reduces pain, and nerve damage, controls blood sugar, increases blood circulation in the feet, and improves symptoms of peripheral neuropathy such as tingling and numbness.

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Hypokalemia in Diabetes Mellitus Setting

Cited by 24 publications

References 43 publications

Potential of Pterocarpus erinaceus Aqueous Stem Bark Extract to Prevent Oxidative Kidney Damage in Diabetic Rats

Potential of Pterocarpus erinaceus Aqueous Stem Bark Extract to Prevent Oxidative Kidney Damage in Diabetic Rats

Multiple Dyselectrolytemia in a Chronic Alcohol Abuser: A Case Report

Foot Exercise to Overcome Type 2 Diabetes Mellitus: A literature Review

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