Hypolipidaemic Effect ofHericium erinaceumGrown inArtemisia capillarison Obese Rats

Abstract

In this study, ethanolic extracts from Hericium erinaceum cultivated with Artemisia capillaris (HEAC) were assessed for their ability to lower the cholesterol levels of male Sprague-Dawley rats fed a high-fat diet. Rats were randomly subdivided into seven test groups. Each group contained eight rats fed a high-fat diet during a growth period lasting 4 wk. Supplementation with the extracts was performed once a day for 2 wk after the high-fat diet. The control group (rats fed a high-fat diet) showed a high efficiency ratio (feed efficiency ratio) value compared to the normal group. Biochemical parameters, including total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), and triglyceride (TG) levels dramatically increased in the control group compared to the normal group. High-density lipoprotein-cholesterol (HDL-c) content in the control group was also significantly lower relative to the normal group. Two positive control groups, treated with simvastatin and atorvastatin, had lowered TC, LDL-c, and TG levels, and increased HDL-c content compared to the control group. Treatment with the tested extracts, including HEAC, ethanolic extracts from Hericium erinaceum, and ethanolic extracts from Artemisia capillaris reduced TC, LDL-c, and TG levels and elevated HDL-c content in the hyperlipidemia rats. The atherogenic index and cardiac risk factor values for the HEAC-treated group were 0.95 and 1.95, respectively. Simvastatin- and atorvastatin-treated groups showed atherogenic index values of 1.56 and 1.69, respectively, and cardiac risk factor values of 2.56 and 2.69, respectively. These results show HEAC possesses an ability to cure hyperlipidemia in rats and may serve as an effective natural medicine for treating hyperlipidemia in humans.

Neuroprotective Potential of Hericium Erinaceus aqueous extract utilization in ischemia-reperfusion injury related middle cerebral artery occlusion stroke model.

“…300mg AEHE, when given orally for 7 days, nonsignificant hypolipidemic effects are seen, whereas in the Pre-MCAO HE group significant decline in TC levels in comparison with the MCAO group was seen, which is consistent with the study of Liang et al, who reported a significant decline in plasma TC levels in streptozotocin induced-diabetic model of Wistar rats fed with AEHE 23 . In our study, HDL levels remained normal in the HE-treated, Pre, and Post-MCAO HE groups, consistent with the results of a study conducted on a hyperlipidemia model of rats given ethanol extract of HE a rise in HDL-C levels 24 .…”

Nanoemulsification of Rice Bran Wax Policosanol Enhances Its Cardio-protective Effects via Modulation of Hepatic Peroxisome Proliferator-activated Receptor gamma in Hyperlipidemic Rats

“…Simvastatin treatment effectively prevented the above pathological changes. This supports recent reports on simvastatin-induced liver histology preservation in high fat diet fed rats 36,47 . Similar preventive effect was observed with all treatments in this study.…”

Red-Koji Fermented Red Ginseng Ameliorates High Fat Diet-Induced Metabolic Disorders in Mice

“…In the present study, a more favorable reduction of glucose levels was observed with fRG compared to an equal dose of RG. On the other hand, the efficacy of hypolipidemic agents is generally evaluated based on the decrease of serum LDL, triglyceride and total cholesterol with increased HDL levels [ 33 , 34 ]. In the present results, HFD-induced hyperlipidemia was markedly inhibited by treatment with fRG 500 and 250 mg/kg, which was confirmed by decreases in serum LDL, total cholesterol and triglyceride and the increase in HDL.…”