Hypolipidemic activity of crude polyphenols from the leaves of Clerodendron colebrookianum Walp in cholesterol fed rats

Boruah, Dulal Chandra; Devi, Rajlakshmi; Tamuli, S. M.; Kotoky, Jibon; Sharma, Dhirendra Kumar

doi:10.1007/s13197-012-0875-9

Cited by 18 publications

(14 citation statements)

References 26 publications

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“…Many polyphenolic compounds possess hypolipidemic activity. They have been shown to increase the fecal fat excretion and LDL receptor activity (Boruah et al, 2014). G. A. is a phenolic compound, which may also possess the same hypolipidemic action.…”

Section: Discussionmentioning

confidence: 99%

Preventive Role of Gum Arabic Administration on STZ Induced Diabetic Kidney Disease in Rats; Renal Antioxidant and Histopathological Evidence

et al. 2020

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This study was set to investigate the effect of gum Arabic (G.A.) on diabetic kidney disease. We divided sixty male Sprague rats randomly into six groups. Normal control, normal rats treated with G.A., untreated diabetic rats, diabetic rats treated with insulin, diabetic rats treated with G.A., and diabetic rats treated with both insulin and G.A. Diabetes was induced by a single intraperitoneal injection of STZ. Forty eight hr post injections. Insulin was injected subcutaneously (1.6/IU/100g/day). We provided G.A. in drinking water (10 %w/ v).). At the end of the twelve weeks, blood was drawn for measurement of blood glucose, glycosylated hemoglobin (HbA1C), serum lipids, serum creatinine, and blood urea. Renal tissue oxidative stress (O.S.) was assessed by measuring the activities of superoxide dismutase (SOD) and catalase (CAT), and the concentrations of reduced glutathione (GSH) and malondialdehyde (MDA). For histological assessments, sections from segments of kidneys were processed and stained with hematoxylin and eosin (H&E) for assessment under the light microscope. STZinduced diabetes caused an elevation of blood glucose, HbA1c, urea and creatinine, triglycerides LDL and cholesterol, MDA with reduction of HDL, GSH level, and CAT and SOD activities. Histologically, kidneys from diabetic rats showed marked glomerular and tubular changes. Administration of G.A. alone to diabetic rats had a significant hypoglycemic, hypolipidemic, and antioxidant effect, although the levels achieved remained significantly abnormal compared with the untreated group with no effect on urea and creatinine levels. Co-administration of G.A. with insulin reversed the impact of D.M. on all parameters evaluated including the histological changes and led to normal urea and creatinine levels. We concluded that G.A., in combination with insulin, improves chemically-induced diabetes and its renal complications, possibly by modulation of oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Preventive Role of Gum Arabic Administration on STZ Induced Diabetic Kidney Disease in Rats; Renal Antioxidant and Histopathological Evidence

et al. 2020

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“…Increased serum concentrations of LDL cholesterol and triglycerides are atherogenic and have been recognized as a risk factor for cardiovascular diseases ( 18 ). An increased HDL level has been considered cardioprotective.…”

Section: Discussionmentioning

confidence: 99%

Hypolipidemic effects of HVC1 in a high cholesterol diet-induced rat model of hyperlipidemia

Kim

Chung

Cheon

et al. 2016

Molecular Medicine Reports

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HVC1, a novel formation containing four herbs, was developed and its hypolipidemic effects in rats with high cholesterol diet (HCD)-induced hyperlipidemia were investigated. The rats were given a HCD for 8 weeks. The HVC1-treated groups were orally administered HVC1 at doses of 10, 50 or 250 mg/kg, respectively, and the simvastatin group was treated at a dose of 10 mg/kg. The normal diet and HCD control groups were administered with physiological saline. Oral administration of HVC1 (10, 50 or 250 mg/kg) significantly reduced the body weight of rats with hyperlipidemia and regulated the total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels in the serum. In addition, tissue analysis revealed that lipid accumulation in the liver and aorta was reduced by HVC1 administration. Furthermore, HVC1 significantly reduced the mRNA expression of peroxisome proliferator-activated receptor-γ, 3-hydroxy-3-methylglutaryl-CoA reductase and low-density lipoprotein receptor, as well as the protein level of 5′ adenosine monophosphate-activated protein kinase in the liver. The results clearly demonstrate that HVC1 has a potent hypolipidemic effect, and suggest that HVC1 should be evaluated as a potential treatment for hyperlipidemia.

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“…The findings of the study suggested that CPCC had a strong hypolipidemic function and could be used as a supplement in healthcare foods and drugs. Ethyl acetate extract of Clerodendrum colebrookianum leaves showed potent hypolipidemic effect in cholesterol fed rats 14 .…”

Section: Hypolipidemic Activitymentioning

confidence: 97%

Phytochemical and Pharmacological Properties of Clerodendrum Colebrookianum Walp: A Review

Lalrinpuia¹,

Bora²,

Upadhyay³

et al. 2018

Int. J. Res. Ayurveda Pharm.

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Clerodendrum colebrookianum Walp is a perennial shrub which is native to South and Southeast Asia. Traditionally, it is used in the treatment of various diseases due to its immense therapeutic potential. It is widely used by the indigenous people of Northeast India as a remedy for treatment of various diseases like diabetes, hypertension, stomachache, jaundice, cough and rheumatism. The plant possesses different biologically active components like Colebrin A, Colebrin B, Colebrin D, Colebrin E, β-Sitosterol etc. This review reported various pharmacological activities of the plant such as antihypertensive, anti-inflammatory, analgesic, hepatoprotective, antioxidant, anthelmintic and some other activities which provide scientific evidence for some traditional therapeutic claims.

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Hypolipidemic activity of crude polyphenols from the leaves of Clerodendron colebrookianum Walp in cholesterol fed rats

Cited by 18 publications

References 26 publications

Preventive Role of Gum Arabic Administration on STZ Induced Diabetic Kidney Disease in Rats; Renal Antioxidant and Histopathological Evidence

Preventive Role of Gum Arabic Administration on STZ Induced Diabetic Kidney Disease in Rats; Renal Antioxidant and Histopathological Evidence

Hypolipidemic effects of HVC1 in a high cholesterol diet-induced rat model of hyperlipidemia

Phytochemical and Pharmacological Properties of Clerodendrum Colebrookianum Walp: A Review

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