Hypolipidemic effect of ethanolic extract from whole plant of Lactuca runcinata (DC.) in atherogenic diet induced hyperlipidemic rats

Devi, Jeyaraman Amutha Iswarya; Muthu, A. Kottai

doi:10.5897/ajpp2015.4447

Cited by 3 publications

(3 citation statements)

References 35 publications

(30 reference statements)

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“…Lactuca runcinata DC.) in 1% gum acacia upon rats (Devi and Muthu, 2015). Subsequent administration of the extract at dose 2,000 mg/kg body weight of rats for 14 days showed no toxicity effect, and this dose had helped in the reduction of total cholesterol and elevated the HDL level.…”

Section: Toxicological Studiesmentioning

confidence: 85%

“…Launaea intybacea (Jacq.) Beauverd exhibited curative and preventive activity against hyperlipidemia (Devi and Muthu, 2015). Its ethanolic extract of the whole plant reduced cardiac risk ration, plasma lipid, and lipoprotein profile.…”

Section: In Vitromentioning

confidence: 99%

“…It also reduced free cholesterol and ester levels. Its lipid-lowering activity was due to its inhibition of hepatic cholesterogenesis or due to its ability to increase fecal sterol excretion (Devi and Muthu, 2015).…”

Section: In Vitromentioning

confidence: 99%

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A Review on the Potential Use of Medicinal Plants From Asteraceae and Lamiaceae Plant Family in Cardiovascular Diseases

2020

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Cardiovascular diseases are one of the most prevalent diseases worldwide, and its rate of mortality is rising annually. In accordance with the current condition, studies on medicinal plants upon their activity on cardiovascular diseases are often being encouraged to be used in cardiovascular disease management, due to the availability of medicinal values in certain dedicated plants. This review was conducted based on two plant families, which are Asteraceae and Lamiaceae, to study on their action in cardiovascular disease relieving activities, to review the relationship between the phytochemistry of Asteraceae and Lamiaceae families and their effect on cardiovascular diseases, and to study their toxicology. The medicinal plants from these plant family groups are collected based on their effects on the mechanisms that affect the cardiovascular-related disease which are an antioxidant activity, anti-hyperlipidemic or hypocholesterolemia, vasorelaxant effect, antithrombotic action, and diuresis effect. In reference to various studies, the journals that conducted in vivo or in vitro experiments, which were used to prove the specific mechanisms, are included in this review. This is to ensure that the scientific value and the phytochemicals of the involved plants can be seen based on their activity. As a result, various plant species from both Asteraceae and Lamiaceae plant family have been identified and collected based on their study that has proven their effectiveness and uses in cardiovascular diseases. Most of the plants have an antioxidant effect, followed by anti-hyperlipidemia, vasorelaxant, antithrombotic, and diuretic effect from the most available to least available studies, respectively. These are the mechanisms that contribute to various cardiovascular diseases, such as heart attack, stroke, coronary heart disease, and hypertension. Further studies can be conducted on these plant species by identifying their ability and capability to be developed into a new drug or to be used as a medicinal plant in treating various cardiovascular diseases.

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Section: Toxicological Studiesmentioning

confidence: 85%

Section: In Vitromentioning

confidence: 99%

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A Review on the Potential Use of Medicinal Plants From Asteraceae and Lamiaceae Plant Family in Cardiovascular Diseases

2020

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Identification of Bioactive Compounds Present in Kulthi (Macrotyloma uniflorum) Seed Extract by Gas Chromatography-Mass Spectrometry

Abdullah

A.H

Fatema

et al. 2022

RJPT

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The objectives of this research were to determine the chemical composition of the extract of Macrotyloma uniflorum seeds by using Gas chromatography–Mass Spectrometry analysis (GC-MS). GC-MS is a matchless method to study and measure the quantity of organic volatile and semi-volatile compounds. Gas chromatography is employed to separates mixtures into individual components employing a temperature-controlled capillary column. Mass spectrometry is utilized to recognize a variety of components from their mass spectra. In the present study, volatile/semivolatile compounds present inM. uniflorum seed extract were analyzed. M. uniflorum seed extract isextracted by the soxhlet extraction method and then analyzed by GC-MS. A total of 28 compoundswere found and quantified in this study. The major bioactive compounds in M. uniflorum seed extract are: 1,7-Octadiyne, 1-Propanone, 1-phenyl-3-[2-( phenylmethoxy)phenyl] -(16.93%), Benzene, 1-methyl-4-(1,2,2-trimethylcyclopentyl)-, (R)-, Benzene, 1-(1,5-dimethyl-4-hexenyl)- 4-methyl- (13.88%) and à-Farnesene, 1,3,6,10-Dodecatetraene, 3,7,11-trimethyl- (Z,E)- (12.68%). The present investigation revealed that M. uniflorum was composed of variety of metabolites and therapeutic active substances as well as novel substances. These substances could be isolated and further empirically evaluated to confirm their biologic and medicinal activities as well as investigate their mechanism of action.

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GC-MS analysis and antioxidant activity of Gyrocarpus asiaticus Willd.

Maity,

Krishna Padhy,

Kanta Kanthal

et al. 2024

RJPT

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Aims: The plant Gyrocarpus asiaticus Willd mainly found in south India comes under the family Hernandiaceae. Present phytochemical analysis by GC-MS is to identify compounds and their structural determination and examine antioxidant properties of the plant. Methodology: GC-MS analysis of a hydroalcoholic extract of Gyrocarpus asiaticus Willd was done on Shimadzu QP 2010 Ultra, and carrier gas was used as Helium and Nitrogen. In-vitro antioxidant activity of hydroalcoholic extract carried out by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method, Ascorbic acid used as a standard drug and analyzed by UV-Visible spectrophotometer (Analytical 2008). Result: The GC-MS analysis of the hydroalcoholic extract shows there are several phytochemical constituents present. From the library of the GC-MS, there are a total of 105 compounds are identified like Alpha -toluenephosphoric acid, 1,2-Benzenedicarboxylic acid, diethyl ester, n-Tetradecanoic acid, Eicosen-1-ol, N -Tridecoic acid, Phytyl eicosanoate, Pentadecane carboxylic acid, Heptadecanoic acid, 9-Octadecenoic acid, Octadecanoic acid, Doxepin, Rotenone, Vitamin D3, Vitamin D2, Beta carotene, Calcifediol, Vitamin E, Amoxapine, Cholesteone. The in-vitro antioxidant study of 20,40,60,80,100 μg/ml concentration of the hydroalcoholic extract of the plant shows % of free radical scavenging activity like 46.07, 56.27, 68.35, 73.89, and 73.55 and shows IC50 value 44.63. Conclusion: The hydroalcoholic extract of Gyrocarpus asiaticus WILLD shows various biologically active compounds and significant antioxidant activity.

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Hypolipidemic effect of ethanolic extract from whole plant of Lactuca runcinata (DC.) in atherogenic diet induced hyperlipidemic rats

Cited by 3 publications

References 35 publications

A Review on the Potential Use of Medicinal Plants From Asteraceae and Lamiaceae Plant Family in Cardiovascular Diseases

A Review on the Potential Use of Medicinal Plants From Asteraceae and Lamiaceae Plant Family in Cardiovascular Diseases

Identification of Bioactive Compounds Present in Kulthi (Macrotyloma uniflorum) Seed Extract by Gas Chromatography-Mass Spectrometry

GC-MS analysis and antioxidant activity of Gyrocarpus asiaticus Willd.

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