Hypolipidemic Effect of Pleurotus eryngii Extract in Fat-Loaded Mice

Abstract

Summary Pleurotus eryngii water extract (PEE), which showed the most significant inhibitory activity against pancreatic lipase in vitro among eight edible mushrooms, was investigated to determine the mechanism of its anti-lipase activity in vitro and its hypolipidemic effect in fat-loaded mice. The inhibitory effects of mushroom extracts on pancreatic lipase activity were examined using 4-methylumbelliferyl oleate (4-MUO) or trioleoylglycerol emulsified with lecithin, gum arabic or Triton X-100 as a substrate. For in vivo experiments, blood samples were taken after oral administration of corn oil and [ 3 H]trioleoylglycerol with or without PEE to food-deprived mice. PEE inhibited hydrolysis of 4-MUO and trioleoylglycerol emulsified with lecithin or Triton X-100, but not that of trioleoylglycerol emulsified with gum arabic. PEE suppressed the elevations of plasma and chylomicron triacylglycerol levels after oral administration of corn oil, but had no effect on lipoprotein lipase activity.

The preventive effect of cellulose from Pleurotus eryngii on fatty liver of hyperlipidemic rats

“…Pleurotus eryngii could inhibit the hydrolysis methyl umbelliferone oleate and the emulsification of triolein, and decrease the absorbance of fat, and then decrease the triglyceride (TG) and total cholesterol (TC) levels in serum, reduce the damage of atherosclerosis, regulate the activity of Thelper, improve the generation of cytokines, decrease the invasion of inflammatory cells and mast cell, and release allergic dermatitis [5][6][7][8].…”

Hypolipidaemic Effect ofHericium erinaceumGrown inArtemisia capillarison Obese Rats

“…Hyperlipidemia is a major worldwide health problem related to the development of various diseases, including diabetes [2]. Reducing the level of cholesterol in blood plasma is an effective method to treat hyperlipidemia-related diseases.…”

Screening of lipase inhibitors from Scutellaria baicalensis extract using lipase immobilized on magnetic nanoparticles and study on the inhibitory mechanism

“…It is well documented that the incidence rate of type 2 diabetes is escalating worldwide partly due to the increasing prevalence of obesity [11], suggesting a potential relation between anti-obesity and anti-diabetic activity. Obesity is primarily caused by the disorder of lipid metabolism, and lipase inhibitors can inhibit the absorption of dietary triglyceride to prevent obesity [12,13]. Since most herbal plants exhibit multiple pharmaceutical effects through multiple targets [14,15], it is of great interest to find out if S. baicalensis contains lipase inhibitors in addition to α-glucosidase inhibitors.…”