Hypolipidemic Effects of Seed Extract of Celery (<i>Apium graveolens</i>) in Rats

Mm, Kamal; Abushoffa, A.; Disi, Ahmad M.; Aburjai, Talal

doi:10.4103/0973-1296.58149

Cited by 32 publications

(9 citation statements)

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“…In addition, caused a down-regulation in the cardiac expression of iNOS while up-regulation of PPARα expression. Our results agree with the study of Aburjai et al, 2009 who observed the hypolipidemic effects of an ethanol extract of celery seed in an obese animal model system (Aburjai et al, 2009). Celery seeds or extracts are utilized as flavorings in herbal combinations that are marketed as anti-rheumamic formulations and dietary supplements.…”

Section: Correlation Studiessupporting

confidence: 92%

Ameliorative effect of celery seed oil against high-fat diet-induced lipotoxic heart disease in rats

Salem,

Mahmoud,

Shaker

et al. 2024

Biological and Biomedical Journal

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Obesity is a risk factor for heart disease. Persistent exposure to excess lipids in the circulation can harm the heart by accumulating hazardous metabolic byproducts such as reactive oxygen species and ceramides, which can cause myocyte malfunction and death by activating signaling pathways. Herbs are one of the most popular weight-loss alternative medicines in the world. Our study aimed to evaluate the possible effects of celery seed oil against high-fat diet-induced lipotoxicity of heart in rats. The study was conducted on 40 male Wistar rats that were classified into 2 groups. Group I (GpI) served as control. GpII was obese rats, subdivided into four subgroups (untreated, treated with orlistat drug, celery seed oil, and a combination of celery seed oil /orlistat drug. At the end of treatment, all rats were scarified, blood samples and heart tissues of the rats were collected. Celery seed oil showed ameliorative effect against high-fat diet-induced lipotoxic heart disease through multiple interrelated mechanisms including alleviation the histological changes, boosting the antioxidant status, improving lipid profile, and reducing fatty acid accumulation in cardiac tissue. The treatment with a combination of celery seed oil /orlistat drug showed the best effect. In conclusion, celery seed oil could be used for the protection against obesity alone or used as adjuvant with orlistat drugs to enhance their pharmacological effect against lipotoxic heart disease.

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Section: Correlation Studiessupporting

confidence: 92%

Ameliorative effect of celery seed oil against high-fat diet-induced lipotoxic heart disease in rats

Salem,

Mahmoud,

Shaker

et al. 2024

Biological and Biomedical Journal

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“…The coumarins are generally considered to be the most important element of A. graveolens, and it has been demonstrated that coumarins have antioxidant properties and exerted a reduced proliferative activity of cancer cell lines (11,22). Certain bioactive compounds derived from A. graveolens seeds have been described and identified; including Luteolin, linolenic acid, psoralen and oleic acid, all of them have antioxidant properties and growth inhibition on various cancer cell lines through inhibition of tumor cell proliferation by inducing cell cycle arrest and by inducing of apoptosis via intrinsic and extrinsic signaling pathway including glioma cell line C6 and breast cancer MCF-7, Keratinocytes HaCaT (33,34).…”

Section: Discussionmentioning

confidence: 99%

“…During ancient times, Ayurvedic physicians used celery seeds to treat colds, flu, water retention, anemia, poor digestion, various types of arthritis, and certain ailments of the liver and spleen (6,7). Laboratory studies have suggested that a combination of the plant with other plants may have some medicinal effects; for instance, antimicrobial(8), anti-inflammatory (9), antioxidant (10), diuretic properties and can help lower cholesterol levels (11).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anticancer Activities of Crude Extracts of Apium graveolens L. Seeds in Two Cell Lines, RD and L20B in vitro

Al-Jumaily¹

2018

IJCMG

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Present study was designed to evaluate anticancer effect of Apium graveolens seed extracts (aqueous, ethanolic and hexane extracts) in vitro on two cell lines (RD and L20B) using different concentrations of A. graveolens seed extracts (6.25, 12.5, 25, 50, 100 and 200 µg/ml) for an incubation period of 48 hours. The results revealed a clear cytotoxic activity of those extracts on growth of RD cancer cell line, and the effect was concentration-dependent. The results also, suggested that the hexane extract of A. graveolens showed the best cytotoxic activity on RD cell line, especially at the concentrations 100 and 200 µg/ml. In contrast, there was no significant cytotoxic effect of the extracts on the L20B transformed cells, with the exception of hexane extract at the concentration 200 µg/ml, in which a significant growth inhibitory effects were observed.

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“…Kolarovic et al investigated the effects of celery juice on male Wistar laboratory rats and concluded that celery leaves juice has a protective effect (Kolarovic et al, 2009). Celery extracts have exhibited anti-inflammatory, antihyperlipidemic effects in rats (Mansi et al, 2009;Shin et al, 2019). Nitrite is used as a color-fixing and antimicrobial agent in processed meat products.…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Celery Performance Based on Its Germination Percentage

2024

IRJMETS

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Celery is an important source of natural active products that are different, based on mechanism and biological properties. Therefore the current research was carried out at AJ Science College Mirpurkhas during the growing season of 2022 the research was considered based on its germination study was restricted in pot experiments for observing its germination growth. In case of days to emergence POT-I was taken with maximum number of days for variety-I while POT-VII was recorded with minimum number of days. For the variety-II POT-I was reported with maximum number of days whereas the POT-VI was noted with minimum number of days under normal conditions. Considering organic rich soil Variety-I was testified with maximum number of days for POT-I, however the minimum days were observed in POT-VI. In case of Variety-II, POT-II was recorded with greater number of days while the POT-VIII was reported with minimum number of days. It is suggested that plant possess more beneficial and stable environment for growth. Considering germination percentages. Under normal soil conditions Variety-I's total germination percentage of 48.75% was taken into consideration, indicating that this genotype is more suited for future adaptation in this environment. POT-V (70%) and POT-II (60%), exhibited the maximum germination percentage, respectively. Regarding Variety-II which demonstrated total germination percentage (58.75%). While the POT-III was on the top for producing maximum germination percentage (80%). It is suggested that Variety-II performed well in normal environment then Variety-I, so it is necessary to initiate breeding and selection program in Mirpurkhas district. In case of organic soil condition. The total germination percentage under organic soil conditions for Variety-I was obtained (60%). POT-V was exhibited with maximum germination percentage (80%), followed by POT-I (70%).Considering Variety-II which demonstrated greater total percentage value (68.75%). Among the pots result the POT-III showed maximum germination percentage (90%), overall research suggested that genotypes were observed are performing well it should be included for future selection for increasing its commercial value.

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Hypolipidemic Effects of Seed Extract of Celery (Apium graveolens) in Rats

Cited by 32 publications

References 0 publications

Ameliorative effect of celery seed oil against high-fat diet-induced lipotoxic heart disease in rats

Ameliorative effect of celery seed oil against high-fat diet-induced lipotoxic heart disease in rats

Evaluation of Anticancer Activities of Crude Extracts of Apium graveolens L. Seeds in Two Cell Lines, RD and L20B in vitro

Comparative Analysis of Celery Performance Based on Its Germination Percentage

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