Hypomagnesemia in Intracerebral Hemorrhage

Behrouz, Réza; Hafeez, Shaheryar; Mutgi, Sunil A.; Zakaria, Asma; Miller, Chad M.

doi:10.1016/j.wneu.2015.08.036

Cited by 16 publications

(8 citation statements)

References 17 publications

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“…In that cohort, patients with hypomagnesemia had larger mean hematoma volume, though the difference between groups was not significant (reported 43.4 6 61.9 vs 31.1 6 40 mL, p 5 0.9). 29 That study did not present data on patient outcome after hospital discharge. In another observational study, low serum levels of the cation calcium were found to be associated with hematoma volumes and hematoma expansion in spontaneous ICH.…”

Section: Resultsmentioning

confidence: 93%

“…While magnesium's role in coagulation and platelet function is attractive, alternative mechanisms including blood pressure effects, vasodilation, neuroprotection, and glial cell protection may have mediated magnesium's effect rather than hemostasis. [29][30][31][32] However, we observe with interest that in the FAST-MAG trial of acute magnesium administration for stroke, the rate of symptomatic hemorrhagic transformation of ischemic stroke was lower in those receiving magnesium (reported 3.3% vs 2.1%, p 5 0.12), suggesting the possibility of a hemostatic effect. 27 Our study also represents a single center's observational experience and will need to be replicated.…”

Section: Resultsmentioning

confidence: 99%

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Magnesium, hemostasis, and outcomes in patients with intracerebral hemorrhage

et al. 2017

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Magnesium, hemostasis, and outcomes in patients with intracerebral hemorrhage

et al. 2017

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“…1 Kadar magnesium serum diperiksa saat pasien datang dengan nilai normal adalah 1,7-2,4mg/dL. [7][8][9][10][11] Subjek dinyatakan hipomagnesium jika kadar magnesium <1,7mg/dL dan hipermagnesium bila kadar >2,4mg/dL. Derajat klinis stroke ditentukan juga saat pertama kali pasien datang, menggunakan NIHSS yang dikelompokkan menjadi ringan (skor <5), sedang (5)(6)(7)(8)(9)(10)(11)(12)(13)(14) serum dalam batas normal, yaitu 1,92+0,496mg/dL (Tabel 1).…”

Section: Metodeunclassified

“…Kadar magnesium ekstraseluler menurunkan pelepasan endotelin-1 dan meningkatkan prostasiklin/ pg-II yang menyebabkan vasodilatasi. 8 Keterbatasan penelitian ini adalah variasi subjek yang terbatas oleh karena metode pengambilan subjek secara konsekutif, sehingga distribusi subjek tidak normal dan dapat menyebabkan kemungkinan terjadinya bias seleksi subjek. Selain itu, penelitian dilakukan dengan desain potong lintang, yakni pengambilan subjek penelitian dalam satu waktu, sehingga tidak bisa mengetahui kondisi kadar magnesium serum premorbid.…”

Section: Pembahasanunclassified

Hubungan Kadar Magnesium Dengan Volume Hematoma Dan Derajat Klinis Pasien Perdarahan Intraserebral

Santoso

Aliah

Aulina

2020

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Pendahuluan: Kadar magnesium serum yang tinggi saat masuk rumah sakit terkait dengan volume hematoma masuk yang kecil, dengan skor National Institutes of Health Stroke Scale (NIHSS) yang lebih rendah. Tujuan: Menilai hubungan kadar magnesium serum, volume hematoma, dan derajat klinis pada pasien stroke perdarahan intraserebral supratentorial akut. Metode: Penelitian ini menggunakan desain potong lintang terhadap pasien stroke perdarahan intraserebral supratentorial akut, dengan diperiksa kadar magnesium serum dan dinilai derajat klinis stroke berdasarkan NIHSS yang dirawat di RSUP Dr. Wahidin Sudirohusodo, Makassar pada bulan Januari hingga April 2019. Hasil: Didapatkan 32 subjek (18 laki-laki, 14 perempuan) dengan rerata usia 55,81+0,496 tahun dan rerata kadar magnesium serum 1,9244+0,49657 mg/dL. Terdapat korelasi yang bermakna antara kadar magnesium serum dengan volume hematoma dan derajat klinis subjek dengan perdarahan intraserebral supratentorial akut. Berdasakan uji korelasi Spearman, terdapat korelasi volume hematoma dengan derajat klinis secara linear positif yang bermakna, bahwa semakin besar volume hematoma, maka semakin besar NIHSS yang artinya derajat klinis semakin berat. Diskusi: Terdapat korelasi bermakna antara kadar magnesium serum, volume hematoma, dan derajat klinis pada pasien perdarahan intraserebral supratentorial akut. Kata kunci: Derajat klinis (NIHSS), kadar magnesium serum, perdarahan intraserebral akut, volume hematoma

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“…11 Another retrospective study showed that low admission Mg levels occurred in one third of patients with ICH and were associated with worse clinical presentation and intraventricular hemorrhage. 12 The relationship between Mg levels, hematoma volume, and clinical outcome in ICH remains unclear because of limited literature. To clarify this relationship, we sought to evaluate the association of serum Mg levels at admission and at 48 hours with clinical and neuroimaging outcomes in patients with acute spontaneous ICH.…”

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confidence: 99%

Serum Magnesium Levels and Outcomes in Patients With Acute Spontaneous Intracerebral Hemorrhage

Goyal

Tsivgoulis

Malhotra

et al. 2018

JAHA

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BackgroundMagnesium (Mg) has potential hemostatic properties. We sought to investigate the potential association of serum Mg levels (at baseline and at 48 hours) with outcomes in patients with acute spontaneous intracerebral hemorrhage (ICH).Methods and ResultsWe reviewed data on all patients with spontaneous ICH with available Mg levels at baseline, over a 5‐year period. Clinical and radiological outcome measures included initial hematoma volume, admission National Institutes of Health Stroke Scale and ICH scores, in‐hospital mortality, favorable functional outcome (modified Rankin Scale scores, 0–1), and functional independence (modified Rankin Scale scores, 0–2) at discharge. Our study population consisted of 299 patients with ICH (mean age, 61±13 years; mean admission serum Mg, 1.8±0.3 mg/dL). Increasing admission Mg levels strongly correlated with lower admission National Institutes of Health Stroke Scale score (Spearman's r, −0.141; P=0.015), lower ICH score (Spearman's r, −0.153; P=0.009), and lower initial hematoma volume (Spearman's r, −0.153; P=0.012). Higher admission Mg levels were documented in patients with favorable functional outcome (1.9±0.3 versus 1.8±0.3 mg/dL; P=0.025) and functional independence (1.9±0.3 versus 1.8±0.3 mg/dL; P=0.022) at discharge. No association between serum Mg levels at 48 hours and any of the outcome variables was detected. In multiple linear regression analyses, a 0.1‐mg/dL increase in admission serum Mg was independently and negatively associated with the cubed root of hematoma volume at admission (regression coefficient, −0.020; 95% confidence interval, −0.040 to −0.000; P=0.049) and admission ICH score (regression coefficient, −0.053; 95% confidence interval, −0.102 to −0.005; P=0.032).ConclusionsHigher admission Mg levels were independently related to lower admission hematoma volume and lower admission ICH score in patients with acute spontaneous ICH.

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Hypomagnesemia in Intracerebral Hemorrhage

Cited by 16 publications

References 17 publications

Magnesium, hemostasis, and outcomes in patients with intracerebral hemorrhage

Magnesium, hemostasis, and outcomes in patients with intracerebral hemorrhage

Hubungan Kadar Magnesium Dengan Volume Hematoma Dan Derajat Klinis Pasien Perdarahan Intraserebral

Serum Magnesium Levels and Outcomes in Patients With Acute Spontaneous Intracerebral Hemorrhage

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