Hypothalamic melatonin receptor sites revealed by autoradiography

Vanĕcek, J; Pavlík, A; Illnerová, Helena

doi:10.1016/0006-8993(87)91625-8

Cited by 388 publications

(160 citation statements)

References 18 publications

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“…Melatonin receptors have been localized in the hypothalamus and the pituitary of many species confirming a central site of action for melatonin in these processes (Vanecek et al 1987, Morgan et al 1989, Weaver et al 1993, Reppert et al 1994. However, based on the identification of putative melatonin binding sites in peripheral tissues such as the intestine (Pointoire et al 1993), cerebral arteries (Viswanathan et al 1993) and kidney (Song et al 1993(Song et al , 1995a(Song et al ,b, 1997 it is now thought that melatonin may have a potentially wider role than the control of seasonal and circadian rhythmicity.…”

Section: Introductionmentioning

confidence: 91%

Melatonin receptors in the human fetal kidney: 2-[125I]iodomelatonin binding sites correlated with expression of Mel1a and Mel1b receptor genes

Drew¹,

Williams²,

Hannah³

et al. 1998

Journal of Endocrinology

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Melatonin receptors in the human fetal kidney were identified and characterized by quantitative in vitro autoradiography using the melatonin agonist, 2-[ 125 I]iodomelatonin. Specific binding was localized to cells in the nephrogenic region at the outer perimeter of the developing kidney and was time-dependent, saturable and inhibited in the presence of guanosine 5 -0-(3-thiotriphosphate) indicative of a G protein-coupled receptor. Expression of the Mel1a and Mel1b melatonin receptors in human fetal kidney was determined using RT-PCR. In situ hybridization confirmed the localization of the Mel1a mRNA transcripts. A role for melatonin in development of the human fetal kidney is postulated.

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Section: Introductionmentioning

confidence: 91%

Melatonin receptors in the human fetal kidney: 2-[125I]iodomelatonin binding sites correlated with expression of Mel1a and Mel1b receptor genes

Drew¹,

Williams²,

Hannah³

et al. 1998

Journal of Endocrinology

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“…The effect of PACAP on CREB 312 phosphorylation culminates in the first part of the dark period of the 24-h cycle (Maronde et al, 1997) in concomitance with the peak of PACAP content in the pineal gland (Fukuhara et al, 1998). PACAP causes phosphorylation of CREB in the SCN during the light period, and the effect of PACAP on CREB is suppressed by melatonin (Vanȇcek et al, 1987;Kopp et al, 1997;von Gall et al, 1998). Likewise, melatonin blocks PACAP-induced stimulation of cAMP production in the whole chicken hypothalamus and in the rat SCN, indicating that the hypothalamus is a site for a functional interaction between PACAP and the pineal hormone melatonin (von Gall et al, 1998;Kopp et al, 1999;Nowak et al, 1999).…”

Section: Actions Of Pituitary Adenylate Cyclase-activating Polypeptidmentioning

confidence: 99%

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

et al. 2009

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“…These inhibitory effects of melatonin are primarily exerted via the hypothalamo-hypophysial axis [16,19,28,34]. Melatonin receptor sites have been visualized in the hypothalamus [36]. It has been reported that melatonin down regulates gonadotropin-releasing hormone (GnRH) induced luteinizing hormone (LH) release from the anterior pituitary gland [35].…”

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confidence: 99%