Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior

Abstract

Adult hippocampal neurogenesis (AHN) plays a critical role in memory and emotion processing, and this process is dynamically regulated by neural circuit activity. However, it remains unknown whether manipulating neural circuit activity can achieve sufficient neurogenic effects to modulate behavior. Here we report that chronic patterned optogenetic stimulation of supramammillary nucleus (SuM) neurons in the mouse hypothalamus robustly promotes neurogenesis at multiple stages, leading to increased production of behaviorally-relevant adult-born neurons (ABNs) with enhanced maturity. Functionally, selectively manipulating activity of these SuM-promoted ABNs modulates memory retrieval and anxiety-like behaviors. Furthermore, we show that SuM neurons are highly responsive to environmental novelty (EN) and are required for EN-induced enhancement of neurogenesis. Moreover, SuM is required for ABN activity-dependent behavioral modulation under novel environment. Our study identifies a key hypothalamic circuit that couples novelty signals to the production and maturation of ABNs, and highlights activity-dependent contribution of circuit-modified ABNs in behavioral regulation.

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“…Additionally, in TH→CA1→DG from trajectory bundle II, it seems that neuronal cells are the main participators, and cell population proliferation is the highest changing pathway, which is supported by a recent study 41 that hypothalamic circuits could modulate adult hippocampal neurogenesis for memory regulation.…”

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“…Recent work shows that glutamate promotes asymmetric, self-renewing NSC divisions [12][13][14] . However, the molecular mediator by which glutamate stimulates NSCs is unclear.…”

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