Hypothalamic Neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat

Kallupi, Marsida; Guglielmo, Giordano de; Cannella, Nazzareno; Li, Hong Wu; Calò, Girolamo; Guerrini, Remo; Ubaldi, Massimo; Renger, John J.; Uebele, Victor N.; Ciccocioppo, Roberto

doi:10.1007/s00213-012-2910-y

Cited by 33 publications

(29 citation statements)

References 28 publications

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“…And interestingly, the response-reinstating effect of menthol was observed only in rats that had been trained to self-administer nicotine with pre-session menthol but not in the rats that had received exactly the same nicotine self-administration training but without pre-session menthol. This finding can be explained in the frame of the above discussed occasion-setting effect of menthol and is consistent with previous studies, in which discriminative stimuli effectively reinstated extinguished drug-seeking behavior in animals that were trained to self-administer cocaine, heroin, alcohol, nicotine, and sucrose (Alvarez-Jaimes et al, 2008; Barker et al, 2014; Burbassi and Cervo, 2008; Ciccocioppo et al, 2001; Gracy et al, 2000; Kallupi et al, 2013; Katner et al, 1999; Widholm et al, 2011; Wing and Shoaib, 2008). The present results mirror our previous report that showed that caffeine influences nicotine seeking (Liu and Jernigan, 2012).…”

Section: Discussionsupporting

confidence: 92%

Effects of menthol and its interaction with nicotine-conditioned cue on nicotine-seeking behavior in rats

et al. 2017

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Rationale Increasing clinical evidence suggests that menthol, a significant flavoring additive in tobacco products, may contribute to smoking and nicotine dependence. Relapse to smoking behavior presents a formidable challenge for the treatment of tobacco addiction. An unresolved issue is whether the mentholation of tobacco products precipitates relapse to tobacco use in abstinent smokers. Objectives The present study examined the effects of menthol on the perseverance and relapse of nicotine-seeking behavior in rats. Methods Male Sprague-Dawley rats were trained to press a lever for intravenous nicotine self-administration (0.03 mg/kg/infusion) under a fixed-ratio 5 schedule of reinforcement. Each nicotine infusion was signaled by the presentation of a sensory stimulus that was established as a discrete nicotine-conditioned cue. Five minutes prior to the sessions, the rats received an intraperitoneal injection of menthol (0.1 mg/kg) or vehicle. In the subsequent extinction test sessions, nicotine was unavailable with or without menthol and/or the nicotine-conditioned cue. The reinstatement tests were performed the following day after the extinction criterion was met. Menthol was also tested on food-seeking responses. In a subset of nicotine-trained rats, a TRPM8 antagonist RQ-00203078 was given prior to menthol administration. Results Continued administration of menthol sustained responses on the previously active and nicotine-reinforced lever in the extinction tests. The re-administration of menthol after extinction reinstated active lever responses. In both the extinction and reinstatement tests, a combination of pre-session menthol administration and cue re-presentation during the session produced a more robust behavioral effect than either menthol or the cue alone. No such effects of menthol was observed in food trained rats. RQ-00203078 did not change menthol effect on nicotine seeking. Conclusion These data demonstrated that menthol specifically sustained and reinstated nicotine-seeking behavior and this effect was independent of TRPM8 activity. These findings suggest that menthol in most tobacco products, even not menthol-labeled, may contribute to the perseverance of and relapse to tobacco-seeking behavior.

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Section: Discussionsupporting

confidence: 92%

Effects of menthol and its interaction with nicotine-conditioned cue on nicotine-seeking behavior in rats

et al. 2017

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“…This finding agrees with a previous study reporting that RTI-118 also produced a dose-dependent and nearly complete elimination of cocaine self-administration in rats while producing little or no effect on food-maintained responding (Schmoutz et al, 2012). RTI-118 and other NPS receptor antagonists have also been found to block cue-, cocaine-, and stress-induced reinstatement of cocaine self-administration in rats and mice (Kallupi et al, 2010; Kallupi et al, 2013; Paneda et al, 2009; Schmoutz et al, 2012). Taken together, these results support further consideration of NPS receptor antagonists as treatments for cocaine abuse and dependence.…”

Section: Discussionmentioning

confidence: 99%

Effects of the neuropeptide S receptor antagonist RTI-118 on abuse-related facilitation of intracranial self-stimulation produced by cocaine and methylenedioxypyrovalerone (MDPV) in rats

Bonano

Runyon

Hassler

et al. 2014

European Journal of Pharmacology

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Neuropeptide S (NPS) is a neurotransmitter that activates the NPS receptor to modulate biological functions including anxiety-like behaviors, feeding, and drug reinforcement. RTI-118 is a novel NPS receptor antagonist that decreased cocaine self-administration in rats at doses that had little or no effect on food-maintained responding. To build on these previous findings, this study examined effects of RTI-118 on cocaine-induced facilitation of intracranial self-stimulation (ICSS) in rats. To provide a context for data interpretation, effects of RTI-118 were compared to effects of the kappa opioid receptor agonist U69,593, because the kappa opioid receptor is another peptide neurotransmitter receptor reported to modulate abuse-related cocaine effects. RTI-118 effects were also examined on ICSS facilitation produced by methylenedioxypyrovalerone (MDPV), a novel designer drug of abuse with some cocaine-like effects. Male Sprague-Dawley rats (n=12) with electrodes targeting the medial forebrain bundle responded under a fixed-ratio 1 schedule for range of brain stimulation frequencies. Under control conditions, brain stimulation maintained a frequency-dependent increase in ICSS rates. Cocaine (1.0–10 mg/kg) and MDPV (3.2 mg/kg) facilitated ICSS. RTI-118 (3.2––32 mg/kg) alone produced little effect on ICSS but dose dependently blocked cocaine-induced ICSS facilitation. U69,593 (0.25–0.5 mg/kg) also attenuated cocaine effects, but blockade of cocaine effects was incomplete even at a U69,593 dose that alone depressed ICSS. RTI-118 (32 mg/kg) failed to block MDPV-induced ICSS facilitation. These results support further consideration of NPS receptor antagonists as candidate treatments for cocaine abuse and provide evidence for differential effects of a candidate treatment on abuse-related effects of cocaine and MDPV.

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“…When administered into the LH, NPS enhances reinstatement of alcohol and cocaine seeking triggered by environmental conditioning factors. This effect is blocked by peripheral administration of the OX1 antagonist SB334867, which suggests an important interaction between these two peptidergic systems (15,16,19). In addition, NPS facilitates cocaine reinstatement with mechanisms mimicking, at least in part, the effect of stress and that may involve the corticotropin releasing factor and the Hcrt-1/Ox-A systems as well (20)(21)(22).…”

mentioning

confidence: 86%

“…Guide cannulae for drug injections were stereotaxically aimed at the following regions: LH [we previously demonstrated that NPS stimulates Hcrt-1/Ox-A neurons when microinjected into the perifornical and lateral hypothalamic regions of the rat tuberal hypothalamus (15,19); therefore, in the present work, we used stereotaxic coordinates, allowing us to diffuse NPS into both areas], locus coeruleus (LC), ventral tegmental area (VTA), PVN, and BNST. Cannulae were always implanted bilaterally, except for the injection of the retrotracer in experiment 5 where they were implanted unilaterally in the PVN and BNST.…”

Section: Intracranial Surgerymentioning

confidence: 99%

Activation of Hypocretin-1/Orexin-A Neurons Projecting to the Bed Nucleus of the Stria Terminalis and Paraventricular Nucleus Is Critical for Reinstatement of Alcohol Seeking by Neuropeptide S

Ubaldi

Giordano

Severi

et al. 2016

Biological Psychiatry

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Hypothalamic Neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat

Abstract: The identification of the NPS/NPSR system as an important new element involved in the physiopathology of cocaine addiction and the discovery of the anti-addictive properties of NPSR antagonists opens the possibility of exploring a new mechanism for cocaine addiction treatment.

Cited by 33 publications

References 28 publications

Effects of menthol and its interaction with nicotine-conditioned cue on nicotine-seeking behavior in rats

Effects of menthol and its interaction with nicotine-conditioned cue on nicotine-seeking behavior in rats

Effects of the neuropeptide S receptor antagonist RTI-118 on abuse-related facilitation of intracranial self-stimulation produced by cocaine and methylenedioxypyrovalerone (MDPV) in rats

Activation of Hypocretin-1/Orexin-A Neurons Projecting to the Bed Nucleus of the Stria Terminalis and Paraventricular Nucleus Is Critical for Reinstatement of Alcohol Seeking by Neuropeptide S

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