Hypothalamic Regulation of Obesity

Rodríguez‐Rodríguez, Rosalía; Miralpeix, Cristina

doi:10.3390/ijms222413459

Cited by 8 publications

(4 citation statements)

References 11 publications

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“…None showed significant changes, indicating the absence of peripheral inflammation. It has been reported that inflammation in the hypothalamus, the part of the brain responsible for regulating appetite and metabolism, can lead to an increased appetite and decreased energy expenditure, resulting in weight gain [ 28 , 29 , 30 ], a condition known as “hypothalamic obesity”. Based on this, we investigated the association between hypothalamic inflammation and body weight gain in CST cKO mice.…”

Section: Resultsmentioning

confidence: 99%

Adult-Onset CNS Sulfatide Deficiency Causes Sex-Dependent Metabolic Disruption in Aging

Qiu

Wang

et al. 2023

IJMS

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The interconnection between obesity and central nervous system (CNS) neurological dysfunction has been widely appreciated. Accumulating evidence demonstrates that obesity is a risk factor for CNS neuroinflammation and cognitive impairment. However, the extent to which CNS disruption influences peripheral metabolism remains to be elucidated. We previously reported that myelin-enriched sulfatide loss leads to CNS neuroinflammation and cognitive decline. In this study, we further investigated the impact of CNS sulfatide deficiency on peripheral metabolism while considering sex- and age-specific effects. We found that female sulfatide-deficient mice gained significantly more body weight, exhibited higher basal glucose levels, and were glucose-intolerant during glucose-tolerance test (GTT) compared to age-matched controls under a normal diet, whereas male sulfatide-deficient mice only displayed glucose intolerance at a much older age compared to female sulfatide-deficient mice. Mechanistically, we found that increased body weight was associated with increased food intake and elevated neuroinflammation, especially in the hypothalamus, in a sex-specific manner. Our results suggest that CNS sulfatide deficiency leads to sex-specific alterations in energy homeostasis via dysregulated hypothalamic control of food intake.

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Section: Resultsmentioning

confidence: 99%

Adult-Onset CNS Sulfatide Deficiency Causes Sex-Dependent Metabolic Disruption in Aging

Qiu

Wang

et al. 2023

IJMS

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“…An imbalance between the energy in and the energy out can directly induce the excessive accumulation of fat [ 21 ]. We found that the fat masses of both the epididymal white adipose tissue (eWAT) and perirenal white adipose tissue (pWAT) in the TRIM67 KO mice were heavier than those in the WT mice under HFD exposure ( Figure 4 A).…”

Section: Resultsmentioning

confidence: 99%

TRIM67 Deficiency Exacerbates Hypothalamic Inflammation and Fat Accumulation in Obese Mice

Jia

Chen

Pan

et al. 2022

IJMS

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Obesity has achieved the appearance of a global epidemic and is a serious cause for concern. The hypothalamus, as the central regulator of energy homeostasis, plays a critical role in regulating food intake and energy expenditure. In this study, we show that TRIM67 in the hypothalamus was responsive to body-energy homeostasis whilst a deficiency of TRIM67 exacerbated metabolic disorders in high-fat-diet-induced obese mice. We found exacerbated neuroinflammation and apoptosis in the hypothalamus of obese TRIM67 KO mice. We also found reduced BDNF in the hypothalamus, which affected the fat sympathetic nervous system innervation and contributed to lipid accumulation in adipose tissue under high-fat-diet exposure. In this study, we reveal potential implications between TRIM67 and the hypothalamic function responding to energy overuptake as well as a consideration for the therapeutic diagnosis of obesity.

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“…We observed associations among the striatum, hypothalamus, and cortical cells. The striatum plays an important role in reward processing [67], and the hypothalamus is involved in hormone and nutrient sensing, which maintains body weight, food intake, and energy expenditure [68]. Altered hypothalamic function is related to the dysfunction of the inhibitory circuit, inducing hedonic eating [69].…”

Section: Discussionmentioning

confidence: 99%

Diffusion time-related structure-function coupling reveals differential association with inter-individual variations in body mass index

Namgung

Park

et al. 2023

Preprint

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Body mass index (BMI) is an indicator of obesity, and recent neuroimaging studies have demonstrated inter-individual variations in BMI to be associated with altered brain structure and function. However, how the structure-function correspondence is altered according to BMI is under-investigated. In this study, we combined structural and functional connectivity using Riemannian optimization with varying diffusion time parameters and assessed their association with BMI. First, we simulated functional connectivity from structural connectivity and generated low-dimensional principal gradients of the simulated functional connectivity across diffusion times, where low and high diffusion times indirectly reflected mono- and polysynaptic communication. We found the most apparent cortical hierarchical organization differentiating between low-level sensory and higher-order transmodal regions in the middle of the diffusion time, indicating that the hierarchical organization of the brain may reflect the intermediate mechanisms of mono- and polysynaptic communications. Associations between the simulated gradients and BMI revealed the strongest relationship when the hierarchical structure was most evident. Moreover, the functional gradient-BMI association map showed significant correlations with the cytoarchitectonic measures of the microstructural gradient and moment features, indicating that BMI-related functional connectome alterations were remarkable in higher-order cognitive control-related brain regions. Finally, transcriptomic association analysis provided potential biological underpinnings, specifying gene enrichment in the striatum, hypothalamus, and cortical cells. Our findings provide evidence that structure-function correspondence is strongly coupled with BMI when hierarchical organization is most apparent, and the associations are related to the multiscale properties of the brain, leading to an advanced understanding of the neural mechanisms related to BMI.

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Hypothalamic Regulation of Obesity

Abstract: Obesity has now reached pandemic proportions and represents a major socioeconomic and health problem in our societies [...]

Cited by 8 publications

References 11 publications

Adult-Onset CNS Sulfatide Deficiency Causes Sex-Dependent Metabolic Disruption in Aging

Adult-Onset CNS Sulfatide Deficiency Causes Sex-Dependent Metabolic Disruption in Aging

TRIM67 Deficiency Exacerbates Hypothalamic Inflammation and Fat Accumulation in Obese Mice

Diffusion time-related structure-function coupling reveals differential association with inter-individual variations in body mass index

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