Hypothyroidism induces uterine hyperplasia and inflammation related to sex hormone receptors expression in virgin rabbits

Rodríguez-Castelán, Julia; Moral-Morales, Aylin Del; Piña-Medina, Ana Gabriela; Zepeda-Pérez, Dafne; Castillo-Romano, Marlenne; Méndez-Tepepa, Maribel; Espindola-Lozano, Marlen; Cuevas-Romero, Estela

doi:10.1016/j.lfs.2019.05.063

Cited by 15 publications

(6 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the several factors responsible for reduced reproductive health, thyroid dysfunction is the most common disorder in women. Hypothyroidism modulates the level of gonadal steroids such as estradiol, testosterone, and progesterone along with the expression of their respective receptors that can be related to endometriosis and uterine hyperplasia (Pieczyńska et al, 2011; Rodríguez‐Castelán et al, 2019). Alterations in uterine status have also been associated with body weight gain (Özdemir et al, 2015), a high level of LPO (Pejić et al, 2009), and very recently with hypothyroidism (Ajmani et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of photoperiod on uterine redox/inflammatory and metabolic status of golden hamster, Mesocricetus auratus

2022

View full text Add to dashboard Cite

Photoperiod modulates reproductive physiology at multiple levels in seasonally breeding animals. Golden hamsters are long-day breeders that diminish their fertility during the short days. Photoperiod is known to regulate hormonal milieu and uterus is a hormone-sensitive dynamic tissue. However, there is lack of molecular insight regarding the impact of photoperiod on uterine physiology with respect to redox and metabolic status in Mesocricetus auratus. We evaluated the impact of photoperiod onprogesterone [P4], melatonin, and insulin), their receptor expressions and key markers associated with redox (SIRT-1/FOXO-1), inflammatory (NFĸB/COX-2) and metabolic (IR/GLUT4) status in uterus. Adult female golden hamsters were exposed to different photoperiodic regimes, that is, short photoperiod (SP; 8L:16D) and long photoperiod (LP; 16L:8D) for 12 weeks. SP drastically decreased peripheral hormone profiles (T3, T4, E2, and P4) and compromised uterine histoarchitecture when compared with LP-exposed hamsters. Further, SP markedly decreased thyroid hormone receptor-α (TRα), insulin receptor, and glucose uptake transporter-4 (GLUT-4) expressions in uterus. We noted enhanced uterine oxidative (increased MDA and decreased SOD/CAT levels), SIRT-1/FOXO-1 expression and inflammatory (NFĸB/COX-2) load in SP condition. Further, elevated levels of circulatory insulin, melatonin, and its receptor (MT-1) expression in uterus was noted under SP condition. Thus, we may suggest that photoperiod might regulate uterine seasonality through modulation of local hormonal and redox/metabolic homeostasis thereby may restrict offspring bearing capacity under short days.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Hypothyroidism modulates the level of gonadal steroids such as estradiol, testosterone, and progesterone along with the expression of their respective receptors that can be related to endometriosis and uterine hyperplasia (Pieczyńska et al, 2011;Rodríguez-Castelán et al, 2019). Alterations in uterine status have also been associated…”

Section: Discussionmentioning

confidence: 99%

Impact of photoperiod on uterine redox/inflammatory and metabolic status of golden hamster, Mesocricetus auratus

2022

View full text Add to dashboard Cite

show abstract

“…There is also evidence of a diminished uterine response to estrogen in hypothyroid rats, with the restoration of a normal response in rats treated with T3 [ 102 ]. One suggested mechanism for these observations is the role of thyroid status in the expression of estrogen and progesterone receptors, with hypothyroidism resulting in reduced progesterone receptor and increased estrogen receptor expression [ 103 ]. Consequently, TH appears to exert its effect on uterine physiology and function by altering the responsiveness of uterine cells to estrogen.…”

Section: Thyroid Hormones and Reproductive Physiologymentioning

confidence: 99%

The Thyroid Hormone Axis and Female Reproduction

Brown

Obeng-Gyasi

Hall

et al. 2023

IJMS

View full text Add to dashboard Cite

Thyroid function affects multiple sites of the female hypothalamic-pituitary gonadal (HPG) axis. Disruption of thyroid function has been linked to reproductive dysfunction in women and is associated with menstrual irregularity, infertility, poor pregnancy outcomes, and gynecological conditions such as premature ovarian insufficiency and polycystic ovarian syndrome. Thus, the complex molecular interplay between hormones involved in thyroid and reproductive functions is further compounded by the association of certain common autoimmune states with disorders of the thyroid and the HPG axes. Furthermore, in prepartum and intrapartum states, even relatively minor disruptions have been shown to adversely impact maternal and fetal outcomes, with some differences of opinion in the management of these conditions. In this review, we provide readers with a foundational understanding of the physiology and pathophysiology of thyroid hormone interactions with the female HPG axis. We also share clinical insights into the management of thyroid dysfunction in reproductive-aged women.

show abstract

“…THs and their receptors play an important role in the maintenance of the normal structure and function of the uterus and ovaries [ 38 , 164 ]. As a result, thyroid dysfunction is associated with gynecological diseases, reproductive tumors, and even infertility [ 165 , 166 , 167 ].…”

Section: Clinical Consequences Of the Crosstalk Between Ths And Repro...mentioning

confidence: 99%

A New Perspective on Thyroid Hormones: Crosstalk with Reproductive Hormones in Females

Ren

Zhu

2022

IJMS

View full text Add to dashboard Cite

Accumulating evidence has shown that thyroid hormones (THs) are vital for female reproductive system homeostasis. THs regulate the reproductive functions through thyroid hormone receptors (THRs)-mediated genomic- and integrin-receptor-associated nongenomic mechanisms, depending on TH ligand status and DNA level, as well as transcription and extra-nuclear signaling transduction activities. These processes involve the binding of THs to intracellular THRs and steroid hormone receptors or membrane receptors and the recruitment of hormone-response elements. In addition, THs and other reproductive hormones can activate common signaling pathways due to their structural similarity and shared DNA consensus sequences among thyroid, peptide, and protein hormones and their receptors, thus constituting a complex and reciprocal interaction network. Moreover, THs not only indirectly affect the synthesis, secretion, and action of reproductive hormones, but are also regulated by these hormones at the same time. This crosstalk may be one of the pivotal factors regulating female reproductive behavior and hormone-related diseases, including tumors. Elucidating the interaction mechanism among the aforementioned hormones will contribute to apprehending the etiology of female reproductive diseases, shedding new light on the treatment of gynecological disorders.

show abstract

Hypothyroidism induces uterine hyperplasia and inflammation related to sex hormone receptors expression in virgin rabbits

Cited by 15 publications

References 49 publications

Impact of photoperiod on uterine redox/inflammatory and metabolic status of golden hamster, Mesocricetus auratus

Impact of photoperiod on uterine redox/inflammatory and metabolic status of golden hamster, Mesocricetus auratus

The Thyroid Hormone Axis and Female Reproduction

A New Perspective on Thyroid Hormones: Crosstalk with Reproductive Hormones in Females

Contact Info

Product

Resources

About