2005
DOI: 10.1016/j.heares.2005.04.003
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Hypoxia-induced IL-6 production is associated with activation of MAP kinase, HIF-1, and NF-κB on HEI-OC1 cells

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Cited by 69 publications
(52 citation statements)
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“…3A) did not reverse the effects of hypoxia on Ah-responsiveness. It has also been reported that in some cell types, that hypoxia induced p65 and NFκB (Jeong, Hong, Park, Shin, An, and Kim, 2005) and p65 can inhibit Ah-responsiveness and induction of CYP1A1 by TCDD (Ke, Rabson, Germino, Gallo, and Tian, 2001;Tian, Ke, Denison, Rabson, and Gallo, 1999). However, results in Figure 5A demonstrate that hypoxia does not affect p65 expression in ZR-75 cells; moreover, this protein is expressed primarily in the cytosol under all the treatment conditions.…”
Section: Discussionmentioning
confidence: 57%
See 1 more Smart Citation
“…3A) did not reverse the effects of hypoxia on Ah-responsiveness. It has also been reported that in some cell types, that hypoxia induced p65 and NFκB (Jeong, Hong, Park, Shin, An, and Kim, 2005) and p65 can inhibit Ah-responsiveness and induction of CYP1A1 by TCDD (Ke, Rabson, Germino, Gallo, and Tian, 2001;Tian, Ke, Denison, Rabson, and Gallo, 1999). However, results in Figure 5A demonstrate that hypoxia does not affect p65 expression in ZR-75 cells; moreover, this protein is expressed primarily in the cytosol under all the treatment conditions.…”
Section: Discussionmentioning
confidence: 57%
“…Stress responsive NFκB signaling also inhibits AhR-mediated transactivation (Ke et al, 2001;Tian et al, 1999) and in some cells, hypoxic conditions increase p65 and NFκB expression (Jeong et al, 2005). Therefore, we investigated interactions between hypoxia, NFκB and Ah-responsiveness in ZR-75 cells treated with DMSO or TCDD for 6 and 24 hr under normoxia or hypoxia (Fig.…”
Section: Results Inmentioning
confidence: 99%
“…1A, B, and E). HIF-1␣ has been shown to regulate inflammation and enhance expression of cytokines, including IL-6 (36,37). HIF-1␣ is rapidly targeted for degradation by prolyl hydroxylases (PHDs) but is stabilized through inactivation of PHDs by iron limitation, hypoxia, or the dioxygenase inhibitor DMOG (38).…”
Section: Enterobactin and Ent؉lcn2 Induce Distinct Gene Expression Anmentioning
confidence: 99%
“…The second is a sustained stable phase called long-term heat acclimation, during which a new homeostasis is achieved [19,20]. Hypoxia is a condition of decreased oxygen (O 2 ) levels that elicits homeostatic responses aimed at counteracting the negative effects of O 2 depletion [21]. Hypoxia induces the expression of several genes, such as erythropoietin [22], vascular endothelial growth factor [23], and other agents that favor the adaptation of the organism to the decreased availability of O 2 .…”
Section: Introductionmentioning
confidence: 99%
“…Hypoxia induces the expression of several genes, such as erythropoietin [22], vascular endothelial growth factor [23], and other agents that favor the adaptation of the organism to the decreased availability of O 2 . Hypoxia is an essential developmental and physiological stimulus that plays a key role in the pathophysiology of heart disease, cancer, neuron death, cerebrovascular disease and chronic lung disease, which are the most common cause of mortality in Western nations [21,23]. These findings prompted our interest in the acclimatization processes and possibly influence of these factors on reproductive function of the female rat.…”
Section: Introductionmentioning
confidence: 99%