Hypoxic Enhancement of Quantal Catecholamine Secretion

Taylor, S. C.; Batten, Trevor; Peers, Chris

doi:10.1074/jbc.274.44.31217

Cited by 51 publications

(17 citation statements)

References 43 publications

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“…Further studies demonstrated that hypoxia increases cellular calcium influx, leading to elevated exocytosis (Bournaud et al, 2007; Carpenter et al, 2000; Mojet et al, 1997; Taylor et al, 1999). More recently, the involvement of NADPH oxidase and reactive oxygen species signalling in hypoxia-evoked catecholamine secretion has been established (Souvannakitti et al, 2010).…”

Section: Regulation Of Catecholamine Synthesis and Secretion By Hmentioning

confidence: 99%

Role of Hypoxia and HIF2α in Development of the Sympathoadrenal Cell Lineage and Chromaffin Cell Tumors with Distinct Catecholamine Phenotypic Features

Richter

Qin

Pacák³

et al. 2013

Advances in Pharmacology

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Hypoxia has wide-ranging impact in normal physiology and disease processes. This stimulus evokes changes in gene expression mediated by transcription factors termed hypoxia-inducible factors (HIFs) that affect numerous processes: angiogenesis, cell survival, cellular metabolism, stem cell self- renewal and multipotency, migration, invasiveness and metastatic progression in tumour cells. Over the past decade increasing numbers of reports have emerged documenting differential roles of HIF1α and HIF2α in these processes. In cells of the sympathoadrenal lineage both HIFs differentially mediate influences of hypoxia on catecholamine synthesis and secretion, but HIF2α signalling has particularly prominent functions in regulating developmental processes of growth and differentiation. This article discusses the role of HIF2α and HIF1α in the context of the development, phenotypic features and functions of chromaffin cells. Moreover, current knowledge about tumour formation in cells of the sympathoadrenal lineage, leading to catecholamine producing pheochromocytomas and paragangliomas, is analysed in the light of the HIF2α signalling network.

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Section: Regulation Of Catecholamine Synthesis and Secretion By Hmentioning

confidence: 99%

Role of Hypoxia and HIF2α in Development of the Sympathoadrenal Cell Lineage and Chromaffin Cell Tumors with Distinct Catecholamine Phenotypic Features

Richter

Qin

Pacák³

et al. 2013

Advances in Pharmacology

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“…35 We have recently utilised this model to develop a clinically relevant bioassay for testing the efficacy of antioxidants in AD. 11,29,30 Exposure of cells to amyloid beta peptide residues 1 to 40 (AβP (1-40) ) causes a dramatic enhancement of Ca 2ϩ channel current in the clonal cell line PC12. 29, 30 We have confirmed that this event is linked to the generation of oxidative stressors as it is fully prevented by antioxidants.…”

Section: Pc12 Neuronal Cell Culture Experiments Indicative Of Admentioning

confidence: 99%

Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potential

Giles¹,

Fry²,

Tasker³

et al. 2003

Org. Biomol. Chem.

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Oxidative stress is implicated, either directly or indirectly, in the pathology of a range of human diseases. As a consequence, the development of efficient antioxidants for medical use has become increasingly important. We have synthesised a range of structurally related organo-sulfur, -selenium and -tellurium agents and demonstrated that a combination of electrochemical methodology, in vitro assays and cell culture tests can be used to rationalise the antioxidant activity of these catalytic agents. Based on its exceptionally low anodic oxidation potential (Epa) and high activity against the representative oxidative stressors tert-butyl hydroperoxide and peroxynitrite, 4,4'-dihydroxydiphenyltelluride is predicted to be a potent antioxidant. This compound exhibits a correspondingly high activity with a remarkably low IC50 value of 20 nM, when tested in PC12 cell culture using a bioassay indicative of the early stages of Alzheimer's disease.

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“…Indeed, we observed a strong clustering of upregulated energy-regulatory pathways associated with alternative energy production mechanisms (Figure 3C: GLYCOLYSIS_AND_GLUCONEOGENESIS , PPARAPATHWAY ), with a concomitant down-regulation of the mitochondrial oxidative phosphorylation functions ( ELECTRON_TRANSPORT , MOOTHA_VOXPHOS , MITOCHONDRIA_PATHWAY ). As oxidative and hypoxic events are often associated with the aging process and pathology [2], [7], [8], [11] we extracted PAGE pathways associated with these functions (Figure 3D). We noted that there was strong positive transcript population of age-related pathways ( AGED_MOUSE_CORTEX_UP , ALZHEIMERS_DISEASE_UP ), with a coherent negative population of converse pathways ( ALZHEIMERS_DISEASE_DN , AGEING_BRAIN_DN ).…”

Section: Resultsmentioning

confidence: 99%

Multiple Oxygen Tension Environments Reveal Diverse Patterns of Transcriptional Regulation in Primary Astrocytes

et al. 2011

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The central nervous system normally functions at O2 levels which would be regarded as hypoxic by most other tissues. However, most in vitro studies of neurons and astrocytes are conducted under hyperoxic conditions without consideration of O2-dependent cellular adaptation. We analyzed the reactivity of astrocytes to 1, 4 and 9% O2 tensions compared to the cell culture standard of 20% O2, to investigate their ability to sense and translate this O2 information to transcriptional activity. Variance of ambient O2 tension for rat astrocytes resulted in profound changes in ribosomal activity, cytoskeletal and energy-regulatory mechanisms and cytokine-related signaling. Clustering of transcriptional regulation patterns revealed four distinct response pattern groups that directionally pivoted around the 4% O2 tension, or demonstrated coherent ascending/decreasing gene expression patterns in response to diverse oxygen tensions. Immune response and cell cycle/cancer-related signaling pathway transcriptomic subsets were significantly activated with increasing hypoxia, whilst hemostatic and cardiovascular signaling mechanisms were attenuated with increasing hypoxia. Our data indicate that variant O2 tensions induce specific and physiologically-focused transcript regulation patterns that may underpin important physiological mechanisms that connect higher neurological activity to astrocytic function and ambient oxygen environments. These strongly defined patterns demonstrate a strong bias for physiological transcript programs to pivot around the 4% O2 tension, while uni-modal programs that do not, appear more related to pathological actions. The functional interaction of these transcriptional ‘programs’ may serve to regulate the dynamic vascular responsivity of the central nervous system during periods of stress or heightened activity.

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Hypoxic Enhancement of Quantal Catecholamine Secretion

Cited by 51 publications

References 43 publications

Role of Hypoxia and HIF2α in Development of the Sympathoadrenal Cell Lineage and Chromaffin Cell Tumors with Distinct Catecholamine Phenotypic Features

Role of Hypoxia and HIF2α in Development of the Sympathoadrenal Cell Lineage and Chromaffin Cell Tumors with Distinct Catecholamine Phenotypic Features

Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potential

Multiple Oxygen Tension Environments Reveal Diverse Patterns of Transcriptional Regulation in Primary Astrocytes

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