<i>A Handbook of the Troubadours.</i>F. R. P. Akehurst , Judith M. Davis

Kay, Sarah

doi:10.2307/2886877

Cited by 5 publications

(6 citation statements)

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“…As shown in Fig. 2C, the treatment of Reh cells with PI-PLC had minimal e¡ect on the EphB6-Fc fusion protein binding, while a signi¢cant reduction in the GPI-linked surface protein CD24 [39] was observed under the same treatment (Fig. 2D) demonstrating that the assay was functional.…”

Section: Resultsmentioning

confidence: 78%

Ephrin‐B2 is a candidate ligand for the Eph receptor, EphB6

et al. 2000

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No ligand has hitherto been designated for the Eph receptor tyrosine kinase family member, EphB6. Here, expression of an EphB6 ligand in the pro-B leukemic cell line, Reh, is demonstrated by binding of soluble EphB6-Fc fusion protein to the Reh cells. The ligand belongs to the subgroup of membrane spanning ligands, as suggested by the fact that phosphatidylinositol-specific phospholipase C treatment did not abrogate binding of EphB6-Fc. Two transmembrane Eph receptor ligands, ephrin-B1 and ephrin-B2, were identified in Reh cells. Analysis of EphB6-Fc fusion protein binding to ephrin-B1 or ephrin-B2 transfected COS cells revealed a high-affinity saturable binding between EphB6-Fc and ephrin-B2, but not with ephrin-B1. In mice, EphB6 has previously been shown to be expressed in thymus. Here, we show expression of EphB6 in human thymus, as well as the expression of ephrin-B2 in both human and mouse thymus. We conclude that ephrin-B2 may be a physiological ligand for the EphB6 receptor.z 2000 Federation of European Biochemical Societies.

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Section: Resultsmentioning

confidence: 78%

Ephrin‐B2 is a candidate ligand for the Eph receptor, EphB6

et al. 2000

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“…Total RNA was isolated according to Kay et al [15]. It was DNAse-treated (1 h, 37³C, RQ1-DNAse, Promega) to avoid genomic DNA contamination.…”

Section: Rt-pcrmentioning

confidence: 99%

A chloroplastic RNA‐binding protein is a new member of the PPR family

et al. 2000

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“…The key point to focus on here is that the Kay-Radzikowski-Wald singularities occur at the actual onset of chronology violation-at the chronology boundary. By a reductio ad absurdum argument [28], this may be interpreted as indicating the breakdown of semi-classical quantum gravity at the chronology horizon. Since by this argument the chronology horizon cannot be treated by semi-classical methods it follows that time machines themselves cannot be globally treated by semi-classical methods: Time machines (if they exist at all) intrinsically require the use of full quantum gravity to describe the chronology horizon.…”

Section: Chronology Protection Theoremsmentioning

confidence: 99%

“…The application to the chronology protection theorems is immediate: If you interpret the KRW singularity theorems as chronology protection theorems (via the reductio ad absurdum argument [28]) then you deduce the breakdown of semi-classical quantum gravity at the chronology horizon.…”

Section: Definition 1cmentioning

confidence: 99%

The reliability horizon for semi-classical quantum gravity: metric fluctuations are often more important than back-reaction

Visser¹

1997

Physics Letters B

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In this note I introduce the notion of the "reliability horizon" for semi-classical quantum gravity. This reliability horizon is an attempt to quantify the extent to which we should trust semi-classical quantum gravity, and to get a better handle on just where the "Planck regime" resides. I point out that the key obstruction to pushing semi-classical quantum gravity into the Planck regime is often the existence of large metric fluctuations, rather than a large back-reaction. There are many situations where the metric fluctuations become large long before the back-reaction is significant. Issues of this type are fundamental to any attempt at proving Hawking's chronology protection conjecture from first principles, since I shall prove that the onset of chronology violation is always hidden behind the reliability horizon.Revisions: Central definitions and results essentially unchanged. Discussion of the relationship between this letter and the Kay-Radzikowski-Wald singularity theorems greatly extended and clarified. Discussion of reliability horizon near curvature singularities modified. Several references added. Minor typos fixed. Technical T E X modifications. *

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A Handbook of the Troubadours.F. R. P. Akehurst , Judith M. Davis

Cited by 5 publications

References 0 publications

Ephrin‐B2 is a candidate ligand for the Eph receptor, EphB6

Ephrin‐B2 is a candidate ligand for the Eph receptor, EphB6

A chloroplastic RNA‐binding protein is a new member of the PPR family

The reliability horizon for semi-classical quantum gravity: metric fluctuations are often more important than back-reaction

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