<i>Bartonella</i>
            Infection: Treatment And Drug Resistance

Biswas, Sanket; Rolain, Jean‐Marc

doi:10.2217/fmb.10.133

Cited by 59 publications

(48 citation statements)

References 136 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…exist in mammalian host reservoirs and are linked to several human infections, such as cat scratch disease. While Bartonella species are susceptible to most conventional antibiotic classes, the major resistance mechanism characterized to date is related to target modifications for resistance to fluoroquinolones, macrolides, and rifamycins (598). A VceA MDR pump was identified in Bartonella australis (GenBank accession number YP_007461659).…”

Section: Bartonella Sppmentioning

confidence: 99%

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

2015

View full text Add to dashboard Cite

SUMMARY The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous in these bacteria greatly contribute to antibiotic resistance and present a major challenge for antibiotic development. Multidrug pumps, particularly those represented by the clinically relevant AcrAB-TolC and Mex pumps of the resistance-nodulation-division (RND) superfamily, not only mediate intrinsic and acquired multidrug resistance (MDR) but also are involved in other functions, including the bacterial stress response and pathogenicity. Additionally, efflux pumps interact synergistically with other resistance mechanisms (e.g., with the outer membrane permeability barrier) to increase resistance levels. Since the discovery of RND pumps in the early 1990s, remarkable scientific and technological advances have allowed for an in-depth understanding of the structural and biochemical basis, substrate profiles, molecular regulation, and inhibition of MDR pumps. However, the development of clinically useful efflux pump inhibitors and/or new antibiotics that can bypass pump effects continues to be a challenge. Plasmid-borne efflux pump genes (including those for RND pumps) have increasingly been identified. This article highlights the recent progress obtained for organisms of clinical significance, together with methodological considerations for the characterization of MDR pumps.

show abstract

Section: Bartonella Sppmentioning

confidence: 99%

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

2015

View full text Add to dashboard Cite

show abstract

“…( 1 ). Of the 30 Bartonella species/subspecies , 17 have been associated with human infections ( 2 , 3 ).…”

mentioning

confidence: 99%

Bartonella henselaeandB. koehleraeDNA in Birds

Mascarelli¹,

McQuillan²,

Harms³

et al. 2014

Emerg. Infect. Dis.

View full text Add to dashboard Cite

“…The related drugs include anabolic steroids, diethylstilbestrol, corticosteroids, immunosuppressant, [3,4] tamoxifen, [5] androgen, [6] thiopurine, [7] and oral contraceptives. [8,9] In addition, a variety of infectious diseases, such as Bartonella henselae, [10] tuberculosis, [11] acquired immunodeficiency syndrome, [12] gummatous syphilis [13] are reported to be associated with PH. Moreover, PH has been recognized to be concomitant with HCC [14] and hematological malignancies [15] in some cases.…”

Section: Discussionmentioning

confidence: 99%

Peliosis hepatis

Dai

Ren²,

Song³

et al. 2017

Medicine

View full text Add to dashboard Cite

Rationale:Peliosis hepatis (PH) is a rare tumor-like liver lesion composed of multiple blood-filled cavities within the liver parenchyma. It is hard to differentiate PH from other liver lesions by imaging, such as carcinoma, metastases, or abscess.Patient concerns:Here, we reported 2 cases that presented with liver lesions under ultrasound and computed tomography (CT) scanning, without any history of liver diseases or drug usage traced back.Diagnoses:Liver biopsy and laparoscopy were processed, and the lesions were eventually diagnosed as PH by histopathology, which microscopically presented with multiple sinusoidal dilatations with blood-filled cystic spaces.Interventions:After the liver biopsy or laparoscopy, the patients were discharged and followed up in the clinic.Outcomes:Both patients were followed up for at least 1 year with good recovery.Lessons:PH should always be recognized in the differentiation of liver lesions, particularly indistinctive lesion(s) without any history of liver-related diseases.

show abstract

Bartonella Infection: Treatment And Drug Resistance

Cited by 59 publications

References 136 publications

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

Bartonella henselaeandB. koehleraeDNA in Birds

Peliosis hepatis

Contact Info

Product

Resources

About