Chlorella sorokiniana Extract Prevents Cisplatin-Induced Myelotoxicity In Vitro and In Vivo

Lin, Shyh-Horng; Li, Ming-Han; Chuang, Kai-An; Lin, Ni‐Hsuan; Chang, Chien-Hung; Wu, Hsin-Chieh; Chao, Ya‐Hsuan; Lin, Chi‐Chien; Pan, I-Hong; Perng, Ming‐Der; Wen, Shu-Fang

doi:10.1155/2020/7353618

Cited by 8 publications

(3 citation statements)

References 69 publications

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“…Lycopene isolated from chlorella inhibited the growth of prostate cancer cells in [64]. In an animal model, chlorella extract reduced bone marrow suppression caused by cisplatin [8]. Clinical data on chlorella treatment include only a small group of breast cancer patients [31].…”

Section: Chlorellamentioning

confidence: 99%

Complementary and Alternative Therapies in Oncology

Dawczak-Dębicka

Kufel-Grabowska

Bartoszkiewicz

et al. 2022

IJERPH

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Cancer is the second leading cause of death worldwide, after cardiovascular diseases. Increasing patients’ awareness and providing easier access to public information result in greater interest in alternative anticancer or unproven supportive therapies. Fear of cancer and limited trust in the treating physician are also important reasons leading patients to seek these methods. Trust and good communication are essential to achieving truthful collaboration between physicians and patients. Given the popularity of CAM, better knowledge about these alternative practices may help oncologists discuss this issue with their patients. This article objectively reviews the most common unconventional therapies used by cancer patients.

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Section: Chlorellamentioning

confidence: 99%

Complementary and Alternative Therapies in Oncology

Dawczak-Dębicka

Kufel-Grabowska

Bartoszkiewicz

et al. 2022

IJERPH

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“…This fraction showed typical signals of fatty acids as analyzed by 1 H-and 13 C-NMR spectra (Chou et al, 2008). Most recently, Lin et al reported that Chlorella sorokiniana (W87) extract prevented cisplatin-induced myelotoxicity in vitro and in vivo, however, the main components were unrevealed (Lin et al, 2020). Yun and colleagues also reported that Chlorella sorokiniana KNUA114, which was collected from Ulleung Island South Korea, was rich in fatty acids and might potentially be used as biological resources (Yun et al, 2020).…”

Section: Introductionmentioning

confidence: 98%

Anti-Inflammatory Effect of Acetone Extracts from Microalgae Chlorella sp. WZ13 on RAW264.7 Cells and TPA-induced Ear Edema in Mice

Yang

Fan²,

Yan³

et al. 2022

Front. Mar. Sci.

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Microalgae extracts have a wide range of uses in the field of healthcare and nutrition. However, the use of microalgae extracts in anti-inflammatory properties and their mechanism of action have not yet been fully studied. Here, we show that extracts from Chlorella sp. WZ13 (CSE-WZ13) dose-dependently reduced nitrite production, inhibited the expression of inducible nitric oxide synthase (iNOS) protein, and decreased the production of the gene and inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Using high-content imaging analysis, it was found that CSE-WZ13 inhibited the translocation of nuclear factor kappa B (NF-κB) from the cytoplasm to the nucleus. CSE-WZ13 also exerted anti-inflammatory effects in an ear edema mouse model induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). CSE-WZ13 inhibited edema by 36.17% and 25.66% at a dose of 0.3 and 0.1 mg/ear, respectively. Histological analysis showed that topical application of CSE-WZ13 decreased TPA-induced inflammatory cell infiltration. Our results indicate that CSE-WZ13 may be a useful candidate for the purpose of decreasing inflammation.

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“…Влияние приема хлореллы на уменьшение накопления кадмия, качество жизни больных раком молочной железы, эффективность в иммуномодуляции рассмотрено в работах зарубежных ученых [17][18][19].…”

Section: Introductionunclassified

Advanced Production Technology of Flour-Based Foods with Chlorella Concentrate

Bochkareva

Volshenkova

2020

Food Processing: Techniques and Technology

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Introduction. Semi-finished products require various additives that increase shelf life, improve sensory properties, or decrease raw material costs. Unfortunately, most additives improve neither nutrition nor biological value of the finished product. The present research featured precooked thin pancakes fortified with a chlorella concentrate. This microalgal supplement with scientific-based healthy properties is a unique project of Russian developers. The chlorella concentrate possesses a balanced amino acid composition, vitamins, major nutrient elements, and dietary minerals. Therefore, it can improve the nutrient and biological value of the pancakes. Study objects and methods. The research featured laboratory and industrial samples of precooked pancakes. 3%, 6%, and 10% of the milk were replaced with chlorella concentrate. The quantitative ratio of the components was determined empirically to obtain pancakes of the optimal quality. The batter-making and baking technologies were traditional. The mixing of milk and chlorella concentrate caused no protein aggregation. Results and discussion. The obtained batter was similar with the control sample in viscosity. The sensory properties did not deteriorate. As the proportion of the concentrate increased, the color of the batter changed from pale green to bright green. The sample with 10% of chlorella concentrate had a distinct algae smell. After the milk was replaced with the chlorella concentrate in the amount of 3%, 6%, and 10%, the amino acid composition demonstrated the following changes. The amount of lysine increased by 4.36%, 8.54%, and 14.72%, respectively. The amount of tryptophan increased by 5.46%, 10.75%, and 18.37, respectively. The amount of methionine + cystine increased by 4.04%, 7.94%, and 13.61%, respectively. The introduction of chlorella concentrate raised the content of certain minerals and vitamins, e.g. iron, vitamins of β-carotene, and vitamin C. Conclusions. Chlorella concentrate improved the production technology of flour-based foods. Therefore, it helps to expand the range of this group of precooked products while improving their biological and nutrition value.

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Chlorella sorokiniana Extract Prevents Cisplatin-Induced Myelotoxicity In Vitro and In Vivo

Cited by 8 publications

References 69 publications

Complementary and Alternative Therapies in Oncology

Complementary and Alternative Therapies in Oncology

Anti-Inflammatory Effect of Acetone Extracts from Microalgae Chlorella sp. WZ13 on RAW264.7 Cells and TPA-induced Ear Edema in Mice

Advanced Production Technology of Flour-Based Foods with Chlorella Concentrate

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