2004
DOI: 10.4049/jimmunol.173.10.6312
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Cmv1-Independent Antiviral Role of NK Cells Revealed in Murine Cytomegalovirus-Infected New Zealand White Mice

Abstract: Ly49H+ NK cells play a critical role in innate antiviral immune responses to murine CMV (MCMV). Ly49Hb6 recognition of MCMV-encoded m157 on infected cells activates natural killing required for host resistance. We show that mAb 3D10 (anti-Ly49H) recognizes comparable subsets of NK cells from New Zealand White (NZW), New Zealand Black (NZB), and C57BL/6 spleens. However, virus levels in the spleens of MCMV-infected NZW and NZB mice differed greatly. We found that MCMV replication in infected NZW spleens was lim… Show more

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Cited by 43 publications
(58 citation statements)
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“…In contrast, a disproportionate increase in the viral load was observed for spleens of NZM mice (Fig. 1C), consistent with the lack of highly efficient NK-mediated MCMV resistance in NZM2328 mice (43). Altogether, these data demonstrate that SG function is very sensitive to viral infection in lupusprone and non-lupus-prone strains within days after MCMV infection.…”
Section: Methodsmentioning
confidence: 45%
“…In contrast, a disproportionate increase in the viral load was observed for spleens of NZM mice (Fig. 1C), consistent with the lack of highly efficient NK-mediated MCMV resistance in NZM2328 mice (43). Altogether, these data demonstrate that SG function is very sensitive to viral infection in lupusprone and non-lupus-prone strains within days after MCMV infection.…”
Section: Methodsmentioning
confidence: 45%
“…Experimental mice (8 to 12 weeks of age) were intraperitoneally infected with MCMV (1 ϫ 10 5 PFU). On d 3.5 postinfection (84 to 90 h), spleen and liver virus levels were quantified using quantitative real-time PCR (QPCR) as described previously (29,40). All sample measurements were performed in triplicate.…”
Section: Methodsmentioning
confidence: 99%
“…MCMV (Smith strain, ATCC VR 194) salivary gland stock virus was prepared after serial passage in BALB/c as described previously (29). Experimental mice (8 to 12 weeks of age) were intraperitoneally infected with MCMV (1 ϫ 10 5 PFU).…”
Section: Methodsmentioning
confidence: 99%
“…Work by Jonic et al using B-cell deficient mice clearly supports the hypothesis that humoral responses are dispensable during primary MCMV infection (Jonjic et al, 1994), but B-cell knockout mice used in these studies had a C57BL/6 background. C57BL/ 6 mice have well described alternative pathways to control MCMV Rodriguez et al, 2004;Scalzo et al, 1990), and therefore extrapolating these results to BALB/c mice might be inappropriate. It is therefore possible that antibody responses in BALB/ c mice are more important in viral control than in C57BL/6 mice.…”
Section: Humoral Responses Have Been Fairly Well Characterized Bmentioning
confidence: 99%