<i>Crassocephalum rubens</i> (Juss. Ex Jacq.) S. Moore improves pancreatic histology, insulin secretion, liver and kidney functions and ameliorates oxidative stress in fructose-streptozotocin induced type 2 diabetic rats

Oyebode, Olajumoke A.; Erukainure, Ochuko L.; Sanni, Olakunle; Islam, Md. Shahidul

doi:10.1080/01480545.2020.1716783

Cited by 18 publications

(11 citation statements)

References 43 publications

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“…When β cells are destroyed in the pancreas, secretion of insulin is negatively affected leading to diabetes [3]. It has now developed to be a global world health problem, contributing significantly to morbidity and mortality worldwide [4,5]. According to estimation, about 415 million people of the world's total population are currently living with T2DM, and the number is estimated to reach 642 million by 2040 [6].…”

Section: Introductionmentioning

confidence: 99%

“…According to estimation, about 415 million people of the world's total population are currently living with T2DM, and the number is estimated to reach 642 million by 2040 [6]. Type 2 diabetes mellitus accounts for over 90-95% of all diabetic recorded cases [4] and modified lifestyles such as lack of or reduced physical activity, unhealthy eating habits and urbanization favor the development of T2DM [4]. This occurrence is not just in the developed countries, but also increasing at an alarming rate in developing countries [7].…”

Section: Introductionmentioning

confidence: 99%

“…There is an increase in the prevalence of comorbid cases of T2DM and helminthic infections and these may be associated with environmental and genetical factors [8]. The immunological interactions instigated by helminth infections to their hosts has been reported to polarize the immune system towards a strong type-2 immune response that is associated with immune defense and tissue repair [4].…”

Section: Introductionmentioning

confidence: 99%

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Immunological and Pathophysiological Outcomes of Helminth Infections and Type 2 Diabetes Comorbidity Studies in Humans and Experimental Animals—A Scoping Review

et al. 2021

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Animal and human studies have demonstrated that helminth infections are associated with a decreased prevalence of type 2 diabetes mellitus (T2DM). Lack of exposure to helminth infections has been postulated to be one mechanism to explain the markedly increased prevalence of T2DM in developed countries. However, there is still paucity of information regarding the immunological interactions between helminth infections and T2DM. The study aimed at reviewing peer-reviewed articles on host immune and pathophysiological outcomes from human and laboratory animal studies of helminth infections and T2DM comorbidity. A literature search was carried out in Google Scholar, PubMed, and EBSCOhost databases using the following keywords; immune responses OR immune modulation of helminth infections OR parasites infections AND Type 2 diabetes comorbidity in humans AND experimental/laboratory animals. Results showed that helminth infections provided some degree of protection from the pathology associated with T2DM by modulating the surrounding cytokine and chemokine milieu in humans and animals. Whilst there is some evidence regarding the protective effects of helminth infections to T2DM in cases of comorbidity, there is paucity of research in both laboratory animals and humans, with reference to the immunological and pathophysiological mechanisms which occur during comorbidity, and these constitute gaps for future research.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Immunological and Pathophysiological Outcomes of Helminth Infections and Type 2 Diabetes Comorbidity Studies in Humans and Experimental Animals—A Scoping Review

et al. 2021

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“…T1DM is known as insulin-dependent diabetes mellitus because of the body’s inability to synthesize insulin, the hormone that regulates blood glucose in the body. This may be characterized by pancreatic β-cell dysfunction 62 , 63 or outright destruction of the insulin-secreting beta cells in the pancreas through continuous autoimmune response 64 .…”

Section: Discussionmentioning

confidence: 99%

Systematic and meta-analysis of Mycobacterium avium subsp. paratuberculosis related type 1 and type 2 diabetes mellitus

Ekundayo

Falade

Igere

et al. 2022

Sci Rep

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Global increase in diabetes (DM) prevalence necessitated the need to establish the association between DM and environmental triggers including MAP (Mycobacterium avium subsp. paratuberculosis) that have been postulated to play a role in DM etiopathology for effective management. The present investigation aimed to assess the odds ratio (OR) presenting the association between MAP and DM. MAP-related DM studies were systematically retrieved from 6 databases until 31 September 2021 according to PRISMA principles for data abstraction. The abstracted dataset was fitted to the fixed-effects (FE) and random-effects (RE) models using the Mantel–Haenszel approach. Sixteen studies involving 2072 participants (1152 DM patients (957 type 1 diabetes mellitus (T1DM) & 195 type 2 diabetes mellitus (T2DM)) and 920 healthy controls) met the inclusion criteria. Results revealed a significant association between anti-MAP antibodies (abs) seroprevalence and T1DM (FE: OR 7.47, 95% CI 5.50–10.14, p value < 0.0001; RE: OR 7.92, 95% CI 4.39–14.31, p < 0.0001) and MAP DNA with T1DM (FE: OR 4.70 (95% CI 3.10–7.13, p value < 0.0001), RE: OR 3.90 (95% CI 0.93–16.38, p value = 0.06)). Both anti-MAP abs and MAP DNA based meta-analyses had medium heterogeneity (I2 = 47.2–61.0%). Meanwhile, no significant association between MAP and T2DM (FE: OR 1.13, 95% CI 0.54–2.37, p value = 0.74; RE: OR 1.19; 95% CI 0.34–4.12, p value = 0.69), its OR magnitude exceeded 1 and prediction interval (0.09–15.29) suggest possibility of association between the duo in the future. The leave-one-out sensitivity analysis depicts a robust meta-analysis in all cases. In conclusion, the study manifests a positive association between MAP and T1DM, highlighting that MAP prevention and environmental control would indubitably revolutionize T1DM management. Also, its projects possible link between MAP and T2DM as more data becomes available. However, it remains elusive whether MAP triggers T1/T2DM or a mere comorbidity in T1/T2DM. Epidemiological activities to fill the global/regional data gaps on MAP-related T1DM and T2DM are advocated in order to assess the burden of MAP-related DM and improve their clinical management.

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“…Diabetes mellitus can be classified into several types; however, there are two main forms: type 1 and type 2 diabetes mellitus (4). A commonly shared comorbidity of both types of diabetes is beta-cell death (5), which is a key event in the pathogenesis of both diseases (6).…”

Section: Introductionmentioning

confidence: 99%

Gliclazide and Crassocephalum rubens leaf extract inhibit glucose-induced mitochondrial permeability transition pore (MPTP) opening in isolated pancreas mitochondria of Wistar rats

Obafemi

Afolabi

Falode

et al. 2022

J Herbmed Pharmacol

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Introduction: Mitochondrial permeability transition pore (MPTP) has been implicated in a wide variety of diseases such as cancer, neurodegenerative diseases, and diabetes. Crassocephalum rubens is a leafy vegetable consumed in different parts of Africa for the management of symptoms of diabetes mellitus, inflammation, malaria, and blood pressure. The present study evaluated the modulatory effects of aqueous leaf extract of C. rubens (ACR) and gliclazide on MPTP in the pancreas of Wistar albino rats in vitro. Methods: Pancreatic mitochondria were isolated from experimental animals using standard protocols. Furthermore, MPTP was induced using various concentrations (15, 22.5, 30, and 37.5 mmol/L) of glucose and CaCl2 (3 µM). Alterations in MPTP and ameliorative potential of different concentrations of ACR (8, 24, 40, 56 μg/mL) and gliclazide (0.054 mg/mL) were monitored spectrophotometrically via changes in absorbance at 540 nm for 12 minutes, under sodium succinate energized condition. Results: It was observed that 30 mmol/L, 37.5 mmol/L D-glucose, and Ca2+ significantly induced MPTP opening by 0.635, 5.10, and 9.95 folds, respectively, an effect that was reversed by gliclazide and ACR, in a none-dose dependent manner. In addition, ACR at 56 μg/mL in conjunction with Ca2+ opened the MPTP. Conclusion: Data from this study suggest that gliclazide and ACR, especially at the lower concentrations, possess significant inhibitory effects against MPTP opening in the pancreas of male Wistar albino rats and, therefore, could be useful in protecting beta-cell death usually associated with diabetes mellitus, as well as other conditions in which MPTP opening is implicated.

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Crassocephalum rubens (Juss. Ex Jacq.) S. Moore improves pancreatic histology, insulin secretion, liver and kidney functions and ameliorates oxidative stress in fructose-streptozotocin induced type 2 diabetic rats

Cited by 18 publications

References 43 publications

Immunological and Pathophysiological Outcomes of Helminth Infections and Type 2 Diabetes Comorbidity Studies in Humans and Experimental Animals—A Scoping Review

Immunological and Pathophysiological Outcomes of Helminth Infections and Type 2 Diabetes Comorbidity Studies in Humans and Experimental Animals—A Scoping Review

Systematic and meta-analysis of Mycobacterium avium subsp. paratuberculosis related type 1 and type 2 diabetes mellitus

Gliclazide and Crassocephalum rubens leaf extract inhibit glucose-induced mitochondrial permeability transition pore (MPTP) opening in isolated pancreas mitochondria of Wistar rats

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