CYP1A1 *2B and *4 Polymorphisms are associated with Lung Cancer Susceptibility in Mexican Patients

Gallegos‐Arreola, Martha Patricia; Figuera, Luis E.; Troyo-Sanromán, Rogelio; Morgan-Villela, Gilberto; Puebla-Pérez, Ana Marı́a; Flores-Márquez, María Rosa; Zúñiga‐González, Guillermo Moisés

doi:10.1177/172460080802300104

Cited by 14 publications

(7 citation statements)

References 23 publications

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“…This association depends on the number of cigarettes smoked per day and exposure time; however, in most studies, these parameters are not considered. In this regard, in our study, patients with stage III–IV tumors who smoked had increased risk, and our data are consistent with previous reports [ 39 , 40 ]. Also, the presence of lymph node metastases and chemotherapy type were risk factors for BC patients with stage III–IV tumors.…”

Section: Discussionsupporting

confidence: 93%

“…When the BC group was stratified by tumor stage, as either I–II or III–IV, and compared with the clinical and biochemical characteristics of BC, early menarche (7–10 years), contraceptive hormonal use, familial history, tobacco consumption, metastasis to lymph nodes, and chemotherapy type (FEC) emerged as risk factors. The association of tobacco use with BC is still controversial, and one study showed that smokers had a BC risk of 10–20% compared to nonsmokers [ 38 – 40 ]. This association depends on the number of cigarettes smoked per day and exposure time; however, in most studies, these parameters are not considered.…”

Section: Discussionmentioning

confidence: 99%

“…Among factors that can favor carcinogenesis are individual genetic variations for susceptibility. Polymorphisms, which are low penetrance genes, are risk factors in cancer [ 40 – 44 ]. Folate metabolism has been proposed to be a contributing factor, by promoting DNA hypomethylation of key regulatory genes and uracil misincorporation into DNA, which leads to double-strand breaks and chromosomal aberrations [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

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The association between the 844ins68 polymorphism in the CBS gene and breast cancer

Gallegos‐Arreola¹,

Figuera²,

Ramos-Silva³

et al. 2014

aoms

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IntroductionThe cystathionine beta synthase (CBS) gene plays an important role in homocysteine metabolism because it catalyzes the first step of the transsulfuration pathway, during which homocysteine is converted to cystathionine. Polymorphisms of CBS have been associated with cancer.Material and methodsWe examined the role of the 844ins68 polymorphism by comparing the genotypes of 371 healthy Mexican women with the genotypes of 323 Mexican women with breast cancer (BC).ResultsThe observed genotype frequencies for controls and BC patients were 1% and 2% for Ins/Ins, 13% and 26% for W/Ins, and 86% and 72% for W/W, respectively. We found that the odds ratio (OR) was 2.2, with a 95% confidence interval (95% CI) of 1.5–3.3, p = 0.0001. The association was also evident when comparing the distribution of the W/Ins-Ins/Ins genotypes in patients in the following categories: 1) menopause and high γ-glutamyltransferase (GGT) levels (OR of 2.17, 95% CI: 1.17–4.26, p = 0.02), 2) chemotherapy response and high lactate dehydrogenase (LDH) levels (OR 2.2, 95% CI: 1.08–4.4, p = 0.027), 3) chemotherapy response and high GGT levels (OR 2.46, 95% CI: 1.2–4.8, p = 0.007), and 4) body mass index (BMI) and III–IV tumor stage (OR 3.2, 95% CI: 1.2–8.3, p = 0.013).ConclusionsWe conclude that the genotypes W/Ins-Ins/Ins of the 844ins68 polymorphism in the CBS gene contribute significantly to BC susceptibility in the analyzed sample from the Mexican population.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The association between the 844ins68 polymorphism in the CBS gene and breast cancer

Gallegos‐Arreola¹,

Figuera²,

Ramos-Silva³

et al. 2014

aoms

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“…As for m4 polymorphism, possible associations have been documented between the A allele and risk for lung cancer (Gallegos-Arreola et al, 2008;Shah et al, 2008;Ezzeldin et al, 2017), laryngeal squamous cell carcinoma (Gajecka et al, 2005) and thyroid cancer (Siraj et al, 2008). No association has been observed between m4 polymorphism and breast, colorectal, and gastric cancer (Li et al, 2004;Singh et al, 2007;Amrani et al, 2016, Little et al, 2006Agudo et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms of the Human Cytochrome P450 1A1 (CYP1A1) and Cervical Cancer Susceptibility among Northeast Thai Women

Wongpratate

Ishida

Phuthong

et al. 2020

Asian Pac J Cancer Prev

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Background: CYP1A1 is an enzyme in phase I of the cytochrome P450 (CYP) superfamily, and plays a key role in detoxification of carcinogens. Host genetic predisposition in the CYP1A1 may be associated with an increased susceptibility to cervical cancer.The study aimed to evaluate four common polymorphisms of the CYP1A1 and cervical cancer susceptibility among Northeast Thai women. Methods: A case-control study was conducted involving 204 patients with squamous cell cervical cancer (SCCA) and 204 age-matched healthy controls. DNA was extracted from peripheral blood leucocytes. CYP1A1 m1, m3, and m4 genotypes were detected using PCR-RFLP, whereas the CYP1A1 m2 genotype was investigated using real-time PCR. Haplotype analysis was performed using PHASE algorithm version 2.1.1. Results: CYP1A1 m3 was monomorphic. Association between the common CYP1A1 polymorphisms, m1 and m2, and cervical cancer risk was not observed (p>0.05), nor was any association found between the m1-m2-m4 haplotype and cervical cancer risk (p>0.05). Interestingly, the CA genotype of CYP1A1 m4 was observed in 30.88% of the cervical cancer patients but was absent in healthy controls. Conclusion: Our results demonstrated a possible involvement of the CYP1A1 m4 polymorphism but no other common polymorphisms (viz., m1, m2, and m3) in the risk for cervical cancer.This finding may be useful when screening for risk of cervical cancer among Northeast Thai women.

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“…This is the first time to our knowledge that this allele has been related to high lung cancer risk in a Caucasian population, since similar results have only been observed in Indians [37], African-Americans [38] or Hispanics [39]. In Caucasians, Vineis et al recently detected a positive allele-disease association, but only where the variant occurred in combination with a number of other CYP1A1 and GST polymorphisms [21].…”

Section: Discussionmentioning

confidence: 65%

CYP1A1gene polymorphisms increase lung cancer risk in a high-incidence region of Spain: a case control study

et al. 2010

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BackgroundA rural region in south-west Spain has one of the highest lung cancer incidence rates of the country, as revealed by a previous epidemiological 10-year follow-up study. The present work was undertaken to ascertain the role of CYP1A1 gene polymorphisms and their interaction with tobacco smoking in the development of the disease in this location.MethodsOne-hundred-and-three cases of lung cancer and 265 controls participated in the study. The participants were screened for the presence of four CYP1A1 polymorphisms, namely MspI, Ile462Val, T3205C, and Thr461Asn. Lung cancer risk was estimated as odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression models adjusting for age, sex, and smoking.ResultsThe distribution of the variant CYP1A1 alleles was different from that described for other Caucasian populations, with CYP1A1*2A showing an uncommonly high frequency (p < 0.01). The CYP1A1*2B allele (carrying MspI and Ile462Val mutations) was strongly associated with high lung cancer risk (OR = 4.59, CI:1.4-12.6, p <0.01). The Ile462Val polymorphism was also shown to increase the risk for the disease (OR = 4.51, CI:1.8-11.9; p <0.01) and particularly for squamous-cell (OR = 5.01; CI: 1.6-14.3, p < 0.01) and small-cell lung carcinoma (SCLC) (OR = 6.97, CI: 1.2-81.3; p = 0.04). Moreover, the Thr461Asn polymorphism was found to be associated with SCLC in a Caucasian population for the first time to our knowledge (OR = 8.33, CI: 1.3-15.2, p = 0.04).ConclusionThe results suggest that CYP1A1 polymorphisms contribute to increase lung cancer susceptibility in an area with an uncommon high incidence rate.

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CYP1A1 ^2B* and ^4* Polymorphisms are associated with Lung Cancer Susceptibility in Mexican Patients

Abstract: The results of the study indicate a significant association between 2B/2B and 4/4 genotypes and the risk of developing lung cancer among Mexicans.

Cited by 14 publications

References 23 publications

The association between the 844ins68 polymorphism in the CBS gene and breast cancer

The association between the 844ins68 polymorphism in the CBS gene and breast cancer

Genetic Polymorphisms of the Human Cytochrome P450 1A1 (CYP1A1) and Cervical Cancer Susceptibility among Northeast Thai Women

CYP1A1gene polymorphisms increase lung cancer risk in a high-incidence region of Spain: a case control study

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CYP1A1 *2B and *4 Polymorphisms are associated with Lung Cancer Susceptibility in Mexican Patients

Abstract: The results of the study indicate a significant association between *2B/*2B and *4/*4 genotypes and the risk of developing lung cancer among Mexicans.

Cited by 14 publications

References 23 publications

The association between the 844ins68 polymorphism in the CBS gene and breast cancer

The association between the 844ins68 polymorphism in the CBS gene and breast cancer

Genetic Polymorphisms of the Human Cytochrome P450 1A1 (CYP1A1) and Cervical Cancer Susceptibility among Northeast Thai Women

CYP1A1gene polymorphisms increase lung cancer risk in a high-incidence region of Spain: a case control study

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Product

Resources

About

CYP1A1 ^2B* and ^4* Polymorphisms are associated with Lung Cancer Susceptibility in Mexican Patients

Abstract: The results of the study indicate a significant association between 2B/2B and 4/4 genotypes and the risk of developing lung cancer among Mexicans.