FABP1 Polymorphisms Contribute to Hepatocellular Carcinoma Susceptibility in Chinese Population with Liver Cirrhosis: A Case-Control Study

Abstract

Purpose: Single nucleotide variations in the liver fatty acid binding protein (L-FABP, FABP1) gene lead to changes in cellular signaling pathways and lipid metabolism. FABP1 polymorphisms were associated with some liver diseases, like steatotic hepatocellular carcinoma. However, the association between FABP1 rs1545224 and rs2241883 polymorphisms and hepatitis B virus-related liver cirrhosis (LC) and hepatocellular carcinoma (HCC) has not been reported. We performed this study to explore their relationship.Methods: One thousand individuals (250 healthy controls, 250 chronic HBV (CHB), 250 LC, and 250 HCC patients) were recruited. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were applied to assess the difference in allele and genotype frequencies. Cochran-Armitage trend test was used to evaluate the cumulative effect. Significant difference would be defined when the P value was less than 0.05.Results: The distribution of rs1545224 GG, AG and AA genotypes in healthy controls or CHB carriers was not significant when compared to LC or HCC patients (P>0.05). LC patients carrying at least one A allele are more likely to develop HCC in contrast with those with G allele (P<0.05). After adjustment for confounders, meaningful results were only seen in the comparison between rs1545224 AG+AA genotype carriers and GG genotype carriers among the LC patients (P<0.05). Rs2241883 polymorphism did not influence the risk of developing LC or HCC in healthy and CHB individuals, nor did it influence the risk of HCC in LC patients (P>0.05).Conclusions: Taken together, FABP1 rs1545224 polymorphism might increase HCC risk in LC patients, indicating that FABP1 rs1545224 polymorphism may be related to the process of developing HCC in Chinese patients with LC.

Association of OPG gene polymorphisms with the risk of knee osteoarthritis among Chinese people

“…To sum up, our study provides evidence for associations between the nine SNPs (rs1485286, rs1905786, rs1032128, rs3134056, rs3134058, rs11573828, rs1564861, rs3134053, and rs11573849) of OPG from the OPG/RANK/RANKL system and the risk of knee osteoarthritis. Despite some significant discoveries are revealed in our study, there are still a few limitations (Lin et al, ; Liu et al, ; Wang et al, ). First, our study lacks the part of biological function analysis, which will be crucial for elucidating the role of OPG in knee OA.…”

Association of CD44 polymorphisms and susceptibility to HBV‐related hepatocellular carcinoma in the Chinese population

“…SNPs were reported to be involved in HBV‐related CHB, LC, and HCC. Wand et al observed that FABP1 rs1545224 AG and AA genotypes might increase HCC risk in LC patients when compared to the GG genotype. Results from a meta‐analysis including 3217 cases and 4163 controls showed that miR‐146a rs291016 was associated with increasing hepatitis virus—related HCC risk in overall analysis.…”

GOLGA7 rs11337, a Polymorphism at the MicroRNA Binding Site, Is Associated with Glioma Prognosis

“…SNPs in 3′ UTRs were selected after conducting a literature review. DNA samples were extracted from whole blood using the universal genomic DNA extraction kit (TaKaRa, Kyoto, Japan) 27, 28. DNA concentrations were assessed through spectrophotometry (DU530 UV/VIS spectrophotometer, Beckman Instruments, Fullerton, CA, USA).…”