<i>Fusobacterium nucleatum</i>in Periodontal Health and Disease

doi:10.21775/cimb.013.025

Cited by 129 publications

(15 citation statements)

References 138 publications

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“…In addition, Fusobacteria associated with Fusobacterium spp. bacteremia, colorectal cancer, periodontitis, and ulcerative colitis, were detected with relatively higher abundance in EnB than in EnP [ 68 , 69 , 89 , 97 , 98 , 99 , 100 , 101 ]. Overall, although a number of beneficial bacteria were enriched in EnB rather than in EnP, some harmful bacteria were also overrepresented in EnB.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Gut Microbiota in Urban Thai Individuals Reveals Enterotype-Specific Signature

et al. 2023

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Gut microbiota play vital roles in human health, utilizing indigestible nutrients, producing essential substances, regulating the immune system, and inhibiting pathogen growth. Gut microbial profiles are dependent on populations, geographical locations, and long-term dietary patterns resulting in individual uniqueness. Gut microbiota can be classified into enterotypes based on their patterns. Understanding gut enterotype enables us to interpret the capability in macronutrient digestion, essential substance production, and microbial co-occurrence. However, there is still no detailed characterization of gut microbiota enterotype in urban Thai people. In this study, we characterized the gut microbiota of urban Thai individuals by amplicon sequencing and classified their profiles into enterotypes, including Prevotella (EnP) and Bacteroides (EnB) enterotypes. Enterotypes were associated with lifestyle, dietary habits, bacterial diversity, differential taxa, and microbial pathways. Microbe–microbe interactions have been studied via co-occurrence networks. EnP had lower α-diversities than those in EnB. A correlation analysis revealed that the Prevotella genus, the predominant taxa of EnP, has a negative correlation with α-diversities. Microbial function enrichment analysis revealed that the biosynthesis pathways of B vitamins and fatty acids were significantly enriched in EnP and EnB, respectively. Interestingly, Ruminococcaceae, resistant starch degraders, were the hubs of both enterotypes, and strongly correlated with microbial diversity, suggesting that traditional Thai food, consisting of rice and vegetables, might be the important drivers contributing to the gut microbiota uniqueness in urban Thai individuals. Overall findings revealed the biological uniqueness of gut enterotype in urban Thai people, which will be advantageous for developing gut microbiome-based diagnostic tools.

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Section: Discussionmentioning

confidence: 99%

Characterization of the Gut Microbiota in Urban Thai Individuals Reveals Enterotype-Specific Signature

et al. 2023

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“…The species responsible for that pathological state are, for example, F. nucleatum and F. polymorphum . Moreover, they can form aggregates with other bacteria in the oral cavity [ 104 , 105 ]. Usually, the Gram-negative Hamephilus species are commensal organisms, including the mouth.…”

Section: Discussionmentioning

confidence: 99%

Proteomic analysis of sialoliths from calcified, lipid and mixed groups as a source of potential biomarkers of deposit formation in the salivary glands

et al. 2023

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Salivary stones, also known as sialoliths, are formed in a pathological situation in the salivary glands. So far, neither the mechanism of their formation nor the factors predisposing to their formation are known despite several hypotheses. While they do not directly threaten human life, they significantly deteriorate the patient’s quality of life. Although this is not a typical research material, attempts are made to apply various analytical tools to characterise sialoliths and search for the biomarkers in their proteomes. In this work, we used mass spectrometry and SWATH-MS qualitative and quantitative analysis to investigate the composition and select proteins that may contribute to solid deposits in the salivary glands. Twenty sialoliths, previously characterized spectroscopically and divided into the following groups: calcified (CAL), lipid (LIP) and mixed (MIX), were used for the study. Proteins unique for each of the groups were found, including: for the CAL group among them, e.g. proteins from the S100 group (S100 A8/A12 and P), mucin 7 (MUC7), keratins (KRT1/2/4/5/13), elastase (ELANE) or stomatin (STOM); proteins for the LIP group—transthyretin (TTR), lactotransferrin (LTF), matrix Gla protein (MPG), submandibular gland androgen-regulated protein 3 (SMR3A); mixed stones had the fewest unique proteins. Bacterial proteins present in sialoliths have also been identified. The analysis of the results indicates the possible role of bacterial infections, disturbances in calcium metabolism and neutrophil extracellular traps (NETs) in the formation of sialoliths.

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“…Mucosal epithelia not only are a passive protective barrier but also can initiate immune responses over secretion of a number of cytokines and chemokines [ 79 , 86 ]. F. nucleatum can induce significant changes in the expression of genes related to immune defense responses [ 95 ]. Here, we reviewed the inflammatory and immune responses due to F. nucleatum .…”

Section: F Nucleatum and Immune Responsesmentioning

confidence: 99%

Pathogenic Mechanisms of Fusobacterium nucleatum on Oral Epithelial Cells

Groeger¹,

Zhou²,

Ruf³

et al. 2022

Front. Oral. Health

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Periodontitis is an oral chronic inflammatory disease and may cause tooth loss in adults. Oral epithelial cells provide a barrier for bacteria and participate in the immune response. Fusobacterium nucleatum (F. nucleatum) is one of the common inhabitants of the oral cavity and has been identified as a potential etiologic bacterial agent of oral diseases, such as periodontitis and oral carcinomas. F. nucleatum has been shown to be of importance in the development of diverse human cancers. In the dental biofilm, it exhibits a structural role as a bridging organism, connecting primary colonizers to the largely anaerobic secondary colonizers. It expresses adhesins and is able to induce host cell responses, including the upregulation of defensins and the release of chemokines and interleukins. Like other microorganisms, its detection is achieved through germline-encoded pattern-recognition receptors (PRRs) and pathogen-associated molecular patterns (PAMPs). By identification of the pathogenic mechanisms of F. nucleatum it will be possible to develop effective methods for the diagnosis, prevention, and treatment of diseases in which a F. nucleatum infection is involved. This review summarizes the recent progress in research targeting F. nucleatum and its impact on oral epithelial cells.

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Fusobacterium nucleatumin Periodontal Health and Disease

Cited by 129 publications

References 138 publications

Characterization of the Gut Microbiota in Urban Thai Individuals Reveals Enterotype-Specific Signature

Characterization of the Gut Microbiota in Urban Thai Individuals Reveals Enterotype-Specific Signature

Proteomic analysis of sialoliths from calcified, lipid and mixed groups as a source of potential biomarkers of deposit formation in the salivary glands

Pathogenic Mechanisms of Fusobacterium nucleatum on Oral Epithelial Cells

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