<i>Helicobacter Pylori</i> and Laryngopharyngeal Reflux in Chronic Rhinosinusitis

Dinis, Paulo Borges; Subtil, João

doi:10.1016/j.otohns.2005.10.013

Cited by 37 publications

(23 citation statements)

References 21 publications

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“…Studies have indicated high prevalence of GERD in patients with chronic rhinosinusitis. In addition drug therapy of GERD together with antibiotics has improved symptoms of sinusitis in 79% of patients ( 11 ). Isolation of H. pylori from the respiratory and gastrointestinal tracts in several studies suggests that there may be a close relationship between H. pylori and pathogenesis of various ear, nose and throat problems ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

Determining the Role of Helicobacter pylori in Chronic Sinus Infections Using the Polymerase Chain Reaction

Nikakhlagh

Samarbafzadeh

Jahani

et al. 2015

Jundishapur J Microbiol

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Background:Helicobacter pylori are becoming increasingly recognized as a possible pathological cause of chronic rhinosinusitis (CRS).Objectives:Considering the prevalence of CRS and its impact on quality of life, we decided to determine the role of H. pylori in chronic sinus infections by using the PCR technique.Patients and Methods:In a case-control analytical epidemiologic survey, the study population was selected by consecutive sampling from patients with CRS undergoing endoscopic sinus surgery during years 2010 - 2012. Patients were divided into two groups. The study group consisted of patients with CRS and the control group consisted of patients with nasal obstruction caused by concha bullosa, without inflammation or infection of the sinuses. Sampling was performed during surgery from the infected tissue and from the middle turbinate mucosa. Eventually, bacterial DNA was extracted and used for the PCR test, in order to isolate H. pylori.Results:Nine patients (18%) with CRS had H. pylori isolated from their samples whereas in the control group, H. pylori were only found in two patients (4%); this difference was statistically significant (P = 0.025). The indicator wasn’t statistically significant between males and females. There was no statistical correlation in relative frequency of H. pylori for different age groups (P > 0.05).Conclusions:There was a significant correlation between CRS and presence of H. pylori in sinonasal mucosa. This relationship may reflect the role of H. pylori as one of the pathogenic factors in the development of CRS. However, further studies are required to confirm this role.

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Section: Discussionmentioning

confidence: 99%

Determining the Role of Helicobacter pylori in Chronic Sinus Infections Using the Polymerase Chain Reaction

Nikakhlagh

Samarbafzadeh

Jahani

et al. 2015

Jundishapur J Microbiol

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“…Since that time, the association of LPR with other medical conditions has been recognized. This association encompasses chronic pharyngitis [ 11 ], obstructive sleep apnea [ 12 ], chronic rhinosinusitis [ 13 – 15 ], and asthma [ 16 ]. Furthermore, the awareness of LPR as an airway disease has grown [ 3 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Allergic Rhinitis and Laryngopharyngeal Reflux

Alharethy

Baqays

Mesallam

et al. 2018

BioMed Research International

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Background and Objectives Laryngopharyngeal reflux (LPR) exhibits nonspecific clinical presentations, and these symptoms may be associated with other conditions such as allergies, including allergic rhinitis and laryngitis. However, there is a gap in the literature regarding the correlation of laryngopharyngeal reflux with allergic rhinitis/laryngitis. Hence, the aim of this study is to explore the correlation between these two conditions. Patients and Methods A total of 126 patients with suggestive manifestations of laryngopharyngeal reflux were included in this study. Patients were classified into LPR positive and negative groups based on the results of a 24-hour oropharyngeal pH monitoring system while allergic rhinitis status was assessed with the score for allergic rhinitis (SFAR). The results of the two groups were compared regarding the SFAR score. Correlation between the pH results and SFAR score was explored. Results The LPR positive group demonstrated significantly higher SFAR scores compared to the negative LPR group (p < 0.0001). In addition, the Ryan score was significantly correlated with the SFAR total score and its symptomatology-related items (r ranged between 0.35 and 0.5). Conclusion. It seems that laryngopharyngeal reflux increases patients' self-rating of allergic manifestations. It appears that there is an association between laryngopharyngeal reflux and allergic rhinitis/laryngitis.

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“…Reflux was defined according to symptoms and signs, or pH study, or pepsin detection (Table 1). 4,8,10,16–29 There were 729 CRS patients (304 females), 187 suspected reflux patients, and 149 healthy individuals without reflux or CRS in the papers. Among studies, 47% of CRS patients were females ( N = 304/651).…”

Section: Resultsmentioning

confidence: 99%

Association between laryngopharyngeal reflux, gastroesophageal reflux and recalcitrant chronic rhinosinusitis: A systematic review

Lechien

Saussez

Hopkins

2023

Clinical Otolaryngology

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Objective: To investigate the association between laryngopharyngeal reflux (LPR), gastroesophageal reflux disease (GERD) and recalcitrant chronic rhinosinusitis (CRS).Data Sources: PubMed, Cochrane Library and Scopus.Review Methods: Three investigators searched the specified databases for studies investigating the relationship between LPR, GERD and recalcitrant CRS with or without polyposis. The following outcomes were investigated with PRISMA criteria: age; gender; reflux and CRS diagnosis; association outcomes and potential treatment outcomes. The authors performed a bias analysis of papers and provided recommendations for future studies.Results: A total of 17 studies investigated the association between reflux and recalcitrant CRS. According to pharyngeal pH monitoring, 54% of patients with recalcitrant CRS reported hypo or nasopharyngeal acid reflux events. The number of hypo-and nasopharyngeal acid reflux events was significantly higher in patients compared to healthy individuals in 4 and 2 studies, respectively. Only one study did not report intergroup differences. The proportion of GERD was significantly higher in CRS patients compared to controls, with a prevalence ranging from 32% to 91% of cases.No author considered nonacid reflux events. There was significant heterogeneity in the inclusion criteria; definition of reflux and association outcomes, limiting the ability to draw clear conclusions. Pepsin was found in sinonasal secretions more frequently in CRS patients than controls. Conclusion:Laryngopharyngeal reflux and GERD may be contributing factors of CRS therapeutic resistance, but future studies are needed to confirm the association considering nonacid reflux events.

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Helicobacter Pylori and Laryngopharyngeal Reflux in Chronic Rhinosinusitis

Abstract: B-2b.

Cited by 37 publications

References 21 publications

Determining the Role of Helicobacter pylori in Chronic Sinus Infections Using the Polymerase Chain Reaction

Determining the Role of Helicobacter pylori in Chronic Sinus Infections Using the Polymerase Chain Reaction

Correlation between Allergic Rhinitis and Laryngopharyngeal Reflux

Association between laryngopharyngeal reflux, gastroesophageal reflux and recalcitrant chronic rhinosinusitis: A systematic review

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