Helicobacter pyloriantibodies and gastric cancer: a gender-related difference

Abstract

Helicobacter pylori has been proposed as a causative agent of gastric cancer. The aim of this study was to define serum antibodies response against different H. pylori antigens in patients with gastric cancer. Serum samples were collected from 115 Lithuanian patients with non-cardia gastric cancer and 110 age- and sex-matched controls without cancer. Heat-stable, low-molecular-mass, and outer membrane proteins were used as antigens to analyze serum IgG antibody response against H. pylori by enzyme-linked immunosorbent assay. Seroprevalence of H. pylori using low-molecular-mass antigen was significantly higher in gastric cancer patients, compared to controls (77% versus 57%, p<0.05). Significant differences in the prevalence of H. pylori infection between gastric cancer patients and controls were found in females using all three studied antigens: heat-stable (98% versus 84%, p<0.05), low-molecular-mass (88% versus 48%, p<0.05) and outer membrane proteins (78% versus 57%, p<0.05). In males, no significant differences were revealed between gastric cancer patients and controls. There may be other cofactors in addition to H. pylori that are important for the development of gastric cancer. H. pylori seems, however, to be a more important for development of gastric cancer in females than in males or males may have more confounding risk factors for gastric cancer than females.

Combined serum IgG response toHelicobacter pyloriVacA and CagA predicts gastric cancer

“…A recent study made in Taiwan reported a significant association between the serological response to 19.5‐ and 26.5‐kDa proteins and malignant outcome of H. pylori infection (Shiesh et al , 2000). The detection of IgG antibodies to 30‐kDa band in our gastric cancer patients is also in accordance with our previous study (Janulaityte‐Gunther, 2005), where a significant higher seroprevalence of H. pylori was found in patients with gastric cancer compared with the asymptomatic patient group using the low molecular mass antigen (15–30 kDa).…”

“…A number of studies have shown that H. pylori carriage is associated with adenocarcinoma of the stomach. Our previous study indicated a high prevalence of H. pylori infection in Lithuania when serum IgG antibody response to H. pylori was analyzed in patients with and without gastric cancer using enzyme‐linked immunosorbent assay ( elisa ) (Janulaityte‐Gunther et al , 2005). In that study, using low molecular mass H. pylori antigen, a higher H. pylori seropositivity was detected in gastric cancer patients compared with asymptomatic patients (77% vs. 57%, P <0.05).…”

Helicobacter pylori atsparumas antibiotikams vaikų amžiuje

“…Apie 50 proc. pasaulio populiacijos yra užsikrėtę šiuo mikroorganizmu [2]. Nustatyta, kad H. pylori vaikams gali sąlygoti skrandžio ir dvylikapirštės žarnos opaligės, ūminio ir lėti-nio gastrito, galbūt funkcinės dispepsijos, geležies stokos anemijos išsivystymą.…”

Gastrointestinal, Pancreatic, and Hepatic Cancer During Pregnancy

“…Dietary factors, such as salt preservation of food, may contribute to gastric cancer risk [65]. Infection with Helicobacter pylori is another potential risk factor that recent data suggest may be more important in women than men [66].…”