Helicobacter pylori increases the risk of carotid plaque formation: a clinical evidence

Abstract

Background and aim: Since the relation between Helicobacter pylori ( H. pylori ) and atherosclerosis has been evidenced, we aimed to analyze whether there is a relationship between the patient's H. pylori infection and age, gender, BMI, blood lipids, and carotid plaque formation. Methods: 810 patients from January 2016 to December 2019 were enrolled in this study, and divided the subjects into H. pylori (+) group and H. pylori (-) group based on the results of UBT. To analyze whether H. pylori infection is related to gender, age, BMI, blood lipids, and neck vascular plaque formation. Results: The single-factor analysis showed that the BMI ≥ 25kg/m 2 , triglycerides >1.7 mmol/l, the formation of cervical plaques were significantly higher in patients infected with H. pylori in compared to normal cases. Also, multi-variant logistic regression analysis showed that H. pylori infection affects the BMI ≥ 25kg/m 2 and triglycerides >1.7 mmol/l to induce vascular plaque. Also, we showed that patients with H. pylori infection are 1.424 times higher than the non-infected group to have triglycerides more elevated than 1.7mmol/l. Conclusion: In this study, we conclude that H. pylori infection is an independent risk factor for higher BMI (>25), triglyceride (>1.7 mmol/l), and neck vascular plaque formation. The multi-variant analysis showed that patients with H. pylori infection are prone to have higher BMI, triglycerides, and neck vascular plaque formation over 1.4-times higher in non-infected individuals. KEY MESSAGES H. pylori infection is an independent risk factor for higher BMI, triglyceride, and neck vascular plaque formation. H. pylori can accelerate vascular plaque formation through increasing BMI and triglyceride.

RNA Sequencing Reveals the Differentially Expressed circRNAs between Stable and Unstable Carotid Atherosclerotic Plaques

“…H. pylori infection activates multiple signal transduction pathways that promote inappropriate inflammatory responses and contributes to pathological changes in lipid metabolism and epithelial cell proliferation, survival, and function [ 30 ]. Those events associated with H. pylori are closely related to plaque formation and stability [ 31 , 32 ]. Overall, functional analysis by GO and KEGG annotation revealed the important roles of upregulated circRNAs in regulating the plaque stability of the arterial wall.…”

Probiotics Bring New Hope for Atherosclerosis Prevention and Treatment

“…Numerous studies have confirmed the association between compositional differences in the gut flora and AS [ 114 – 116 ]. In addition, the nucleic acid components of some parenteral pathogenic bacteria have been successively identified in atherosclerotic plaques, such as Porphyromonas gingivalis, Helicobacter pylori, and Chlamydia pneumoniae, which are also important for the progression of AS [ 117 – 119 ]. Therefore, imbalances in gut microbial homeostasis or infection with pathogenic microbes may serve as novel risk factors for AS.…”

Helicobacter pylori infection and the progression of atherosclerosis: A systematic review and meta‑analysis

“…A growing number of observational studies have linked AS to H. pylori. 16,17 Previous studies have suggested that the link may be caused by a chronically infected environment in the body, 18 but there are opposing views that may be there are common risks such as aging, unhealthy diet, and smoking between these. 19 Metaanalysis is an effective way to resolve clinical disputes.…”