<i>Helicobacter pylori</i>-Induced Signaling Pathways Contribute to Intestinal Metaplasia and Gastric Carcinogenesis

Sue, Soichiro; Shibata, Wataru; Maeda, Shin

doi:10.1155/2015/737621

Cited by 54 publications

(47 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously, numerous oncogenic signaling pathways, including the PI3 kinase‐AKT, β‐catenin‐WNT, Hedgehog/GLI, ERK‐MAPK, JNK, and NF‐κB pathways, have been studied and demonstrated to be involved in H. pylori pathogenesis . In this study, we confirmed that some of those signaling pathways are involved in H. pylori ‐associated gastric cancer, such as focal adhesion, Th1 and Th2 cell differentiation, Th17 cell differentiation, bacterial invasion of epithelial cells, epithelial cell signaling, and the NF‐κB and Hedgehog signaling pathways.…”

Section: Discussionsupporting

confidence: 80%

Analysis of key genes and signaling pathways involved in Helicobacter pylori‐associated gastric cancer based on The Cancer Genome Atlas database and RNA sequencing data

Liu

et al. 2018

Helicobacter

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 80%

Analysis of key genes and signaling pathways involved in Helicobacter pylori‐associated gastric cancer based on The Cancer Genome Atlas database and RNA sequencing data

Liu

et al. 2018

Helicobacter

View full text Add to dashboard Cite

show abstract

“…Despite a declining rate of GC over the past decades, the 5‐year survival rate of GC patients is <20% . Moreover, no less than two‐thirds of GC occurs in developing countries, and China has the most GC patients in the world . Despite significant medical progress and efforts in promoting the survival of GC patients, the basic molecular mechanisms of the GC are until recently still not well understood.…”

Section: Introductionmentioning

confidence: 99%

The role and molecular mechanism of Trop2 induced epithelial‐mesenchymal transition through mediated β‐catenin in gastric cancer

et al. 2019

View full text Add to dashboard Cite

The present study elucidates the potential role of Trop2 in tumor invasion and the promotion of epithelial‐mesenchymal transition (EMT) when binding β‐catenin in GC. The role of Trop2 in promoting EMT in GC cells was examined by a variety of experimental assays. Moreover, the underlying molecular mechanism of Trop2 in promoting EMT was studied by in vivo and in vitro assays. The Trop2 expression in relation to tumor metastasis status was detected by IHC in 248 cases of GC tissues and 86 cases of matched adjacent tissues. Trop2 promoted the metastasis and induces EMT in GC. Meanwhile, the elevated protein levels of Trop2 and mesenchymal markers were also found in the TGF‐β1‐induced EMT model in GC cells. Importantly, Trop2 physically bound and activated β‐catenin to promote EMT; moreover, Trop2 increased the accumulation of β‐catenin in the nucleus to accelerate metastasis in GC cells. Inhibition of Trop2 expression in GC cells prevented the migration and invasion of GC cells in vivo. Trop2+/vimentin+ expression was higher in GC tissues than that in matched adjacent tissues, and Trop2+/vimentin+ expression in GC was associated with the differentiation, TNM stage, and distant metastases. These sets of data reveal a novel regulatory network of Trop2 in EMT and GC metastasis, suggesting Trop2 as a useful marker for inducing EMT and metastasis of GC, which may help to lead a better understanding of the pathogenesis of the GC.

show abstract

“…The turning point of the malignant tissue/cell changes is in the status of intestinal metaplasia [20]. While many factors are involved in the progression of GC, aberrant expression of epidermal growth factor receptor (EGFR) and its cognate ligands (e.g.…”

Section: Discussionmentioning

confidence: 99%

Abnormal amphiregulin expression correlates with gastric cancer prognosis

et al. 2016

View full text Add to dashboard Cite

Gastric cancer (GC) is a global health issue with a high mortality rate. Early diagnosis and tracking of GC is a challenge due to a lack of reliable tools. Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family that activates growth signaling upon binding of EGF receptors. Elevated AREG expression is associated with various pathological conditions, including cancer. Here, we investigated whether increased AREG expression is a disease indicator and/or prognostic biomarker for GC. We used tissue microarray and quantitative real-time polymerase chain reaction to assess AREG expression in clinical tissue specimens at various stages of GC and a conducted bioinformatics analysis to evaluate the value of AREG over-expression as a GC biomarker. We found that both mRNA and protein expression of AREG were increased in the tissues of GC patients when compared to tissues from non-cancer patients or normal tissues. High expression of AREG was also associated with GC clinicopathological characteristics and poor survival. Thus, over-expression of AREG could serve as a novel GC biomarker, and active surveillance of its expression could be a novel approach to GC diagnosis and monitoring.

show abstract

Helicobacter pylori-Induced Signaling Pathways Contribute to Intestinal Metaplasia and Gastric Carcinogenesis

Cited by 54 publications

References 89 publications

Analysis of key genes and signaling pathways involved in Helicobacter pylori‐associated gastric cancer based on The Cancer Genome Atlas database and RNA sequencing data

Analysis of key genes and signaling pathways involved in Helicobacter pylori‐associated gastric cancer based on The Cancer Genome Atlas database and RNA sequencing data

The role and molecular mechanism of Trop2 induced epithelial‐mesenchymal transition through mediated β‐catenin in gastric cancer

Abnormal amphiregulin expression correlates with gastric cancer prognosis

Contact Info

Product

Resources

About