In vitro Antioxidant and Cytotoxic Activities of Extracts of Endemic Tanacetum erzincanense Together with Phenolic Content by LC‐ESI‐QTOF‐MS

Yapıcı, İsmail; Altay, Ahmet; Sarıkaya, B.; Korkmaz, Mustafa; Atila, Alptuğ; Gülçın, İlhami; Köksal, Ekrem

doi:10.1002/cbdv.202000812

Cited by 19 publications

(12 citation statements)

References 46 publications

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“…It is considered safe even at high doses, and its toxicity has not been reported in the literature [ 377 ]. Plants belonging to the Asteraceae family, such as the genera Artemisia [ 378 , 379 ], Achillea [ 380 ], Matricaria [ 378 ], and Tanacetum [ 381 ], are the main sources of this compound.…”

Section: Natural Compounds and Important Targets Associated With Chronic Inflammation And Oxidative Stress In Cancer Treatmentmentioning

confidence: 99%

Therapeutic Influence on Important Targets Associated with Chronic Inflammation and Oxidative Stress in Cancer Treatment

Neganova

Liu

Aleksandrova

et al. 2021

Cancers

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Chronic inflammation and oxidative stress are the interconnected pathological processes, which lead to cancer initiation and progression. The growing level of oxidative and inflammatory damage was shown to increase cancer severity and contribute to tumor spread. The overproduction of reactive oxygen species (ROS), which is associated with the reduced capacity of the endogenous cell defense mechanisms and/or metabolic imbalance, is the main contributor to oxidative stress. An abnormal level of ROS was defined as a predisposing factor for the cell transformation that could trigger pro-oncogenic signaling pathways, induce changes in gene expression, and facilitate accumulation of mutations, DNA damage, and genomic instability. Additionally, the activation of transcription factors caused by a prolonged oxidative stress, including NF-κB, p53, HIF1α, etc., leads to the expression of several genes responsible for inflammation. The resulting hyperactivation of inflammatory mediators, including TNFα, TGF-β, interleukins, and prostaglandins can contribute to the development of neoplasia. Pro-inflammatory cytokines were shown to trigger adaptive reactions and the acquisition of resistance by tumor cells to apoptosis, while promoting proliferation, invasion, and angiogenesis. Moreover, the chronic inflammatory response leads to the excessive production of free radicals, which further aggravate the initiated reactions. This review summarizes the recent data and progress in the discovery of mechanisms that associate oxidative stress and chronic inflammation with cancer onset and metastasis. In addition, the review provides insights for the development of therapeutic approaches and the discovery of natural substances that will be able to simultaneously inhibit several key oncological and inflammation-related targets.

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Section: Natural Compounds and Important Targets Associated With Chronic Inflammation And Oxidative Stress In Cancer Treatmentmentioning

confidence: 99%

Therapeutic Influence on Important Targets Associated with Chronic Inflammation and Oxidative Stress in Cancer Treatment

Neganova

Liu

Aleksandrova

et al. 2021

Cancers

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“…The IC50 values of the Ag(I) complex, naproxen, silver, and carboplatin against both cancer and normal cell lines Toxicity tests have been widely performed as a mandatory step to introduce a new chemical drug to the pharmaceutical industry [34][35][36][37]. Many researchers have synthesized numerous novel metal complexes with different metals and ligands belonging to NSAIDs and tested their cytotoxicity against different types of cancer cell lines.…”

Section: T a B L Ementioning

confidence: 99%

Trinuclear silver(I) complex of non-steroidal anti-inflammatory drug naproxen: Synthesis, characterization, and in vitro cytotoxicity

Çağlar

Altay

Harurluoglu

et al. 2021

Maced. J. Chem. Chem. Eng.

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Herein, a new silver(I) complex with the non-steroidal anti-inflammatory drug naproxen and nitrogen donor 3-picoline ligands was synthesized, characterized, and subsequently tested for its cytotoxicity against different types of cancer cell lines. Elemental analysis, Fourier transform infrared spectroscopy, thermal, and proton nuclear magnetic resonance techniques showed that the molecular formula of the prepared complex is bis(3-picoline)tris(-naproxenato)trisilver(I) and naproxen ligands bind to silver ions in a bridging bidentate mode. 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) results revealed that silver salts and naproxen alone showed quite weak cytotoxic activity against human breast adenocarcinoma (MDA-MB-453), lung adenocarcinoma (A-549), and colorectal adenocarcinoma (HT-29) cell lines (IC50 > 250 µM), whereas the complex displayed dose dependent cytotoxicity against the aforementioned cell lines. The highest cytotoxicity was observed on MDA-MB-453 cells with an IC50 value of 11.73 µM. Moreover, the complex showed higher selectivity against the cancer cell lines compared to fibroblast 3T3-L1 cells. This study provides preliminary scientific data on the complex for further elucidation of its anticancer mechanism of action.

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“…If this balance is disturbed and the accumulation of free radicals in the body increases, the antioxidant system cannot protect the cells. [4] As a result, it causes damages such as lipid peroxidation and oxidative stress. [5] One of the most important metabolites found in plant species are phenolic compounds.…”

Section: Introductionmentioning

confidence: 99%

“…Free radicals and antioxidants are in balance with each other. If this balance is disturbed and the accumulation of free radicals in the body increases, the antioxidant system cannot protect the cells [4] . As a result, it causes damages such as lipid peroxidation and oxidative stress [5]…”

Section: Introductionmentioning

confidence: 99%

LC‐HRMS Profiling and Phenolic Content, Cholinesterase, and Antioxidant Activities of Terminalia citrina

Özler

Topal

et al. 2023

Chemistry & Biodiversity

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Terminalia citrina (T. citrina) belongs to the Combretaceae family and is included in the class of medicinal plants in tropical countries such as Bangladesh, Myanmar, and India. The antioxidant activities of lyophilized water (WTE) and alcohol extracts (ETE) of T. citrina fruits, their phenolic content by LC‐HRMS, and their effects on cholinesterases (ChEs; AChE, acetylcholinesterase, and BChE, butyrylcholinesterase) were investigated. Especially ten different analytical methods were applied to determine the antioxidant capacity. Compared with similar studies for natural products in the literature, it was determined that both WTE and ETE exhibited strong antioxidant capacity. Syringe and ellagic acids were higher than other acids in ETE and WTE. IC50 values for ETE and WTE in DPPH radical and ABTS⋅+ scavenging activities were calculated as 1.69–1.68 μg mL−1 and 6.79–5.78 μg mL−1, respectively. The results of the biological investigations showed that ETE and WTE had an inhibition effect against ChEs, with IC50 values of 94.87 and 130.90 mg mL−1 for AChE and 262.55 and 279.70 mg mL−1 for BChE, respectively. These findings indicate that with the prominence of herbal treatments, T. citrina plant may guide the literature in treating Alzheimer's Disease, preventing oxidative damage, and mitochondrial dysfunction.

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In vitro Antioxidant and Cytotoxic Activities of Extracts of Endemic Tanacetum erzincanense Together with Phenolic Content by LC‐ESI‐QTOF‐MS

Cited by 19 publications

References 46 publications

Therapeutic Influence on Important Targets Associated with Chronic Inflammation and Oxidative Stress in Cancer Treatment

Therapeutic Influence on Important Targets Associated with Chronic Inflammation and Oxidative Stress in Cancer Treatment

Trinuclear silver(I) complex of non-steroidal anti-inflammatory drug naproxen: Synthesis, characterization, and in vitro cytotoxicity

LC‐HRMS Profiling and Phenolic Content, Cholinesterase, and Antioxidant Activities of Terminalia citrina

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