<i>In Utero</i>
            Pesticide Exposure and Leukemia in Brazilian Children &lt; 2 Years of Age

Ferreira, Jeniffer Dantas; Couto, Arnaldo Cézar; Pombo-de-Oliveira, Maria do Socorro; Koifman, Sérgio

doi:10.1289/ehp.1103942

Cited by 72 publications

(62 citation statements)

References 26 publications

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“…This is consistent with previous studies showing exposure‐response relationships between the frequency of insecticide exposure and risk of childhood leukemia 3, 5, 7, 11. It is important to consider that, while the use of insecticides inside and around the home has helped reduce mortality and morbidity due to common vector‐borne diseases such as dengue and malaria in Costa Rica and other tropical countries,23, 24 results from the current study highlight the importance of developing alternative strategies to mitigate the risk of these diseases, such as integrated pest management.…”

Section: Discussionsupporting

confidence: 93%

“…Results from our study are largely consistent with previous studies indicating that home insecticide use during pregnancy may be associated with an increased risk of childhood leukemia 3, 4, 6, 7, 15. For instance, in a CLIC pooled analysis of 12 case‐control studies, household use of insecticides or miticides within 3 months of conception, during pregnancy, and after birth was associated with increased odds of ALL [pooled OR = 1.34 (95% CI: 1.19–1.51), 1.28 (95% CI: 1.18–1.38), and 1.23 (95% CI: 1.12–1.34), respectively] 15…”

Section: Discussionsupporting

confidence: 92%

“…To date, multiple studies have examined the association between early‐life residential pesticide exposure and childhood leukemia with mostly consistent results 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14. For example, in a pooled analysis of 12 case‐control studies from the Childhood Leukemia International Consortium (CLIC), increased odds of ALL were observed among children who had any pesticide exposure in their homes shortly before conception, during pregnancy, or after birth [odds ratio (OR) = 1.39 (95% Confidence Interval (95% CI): 1.25–1.55), 1.43 (95% CI: 1.32–1.54), and 1.36 (95% CI: 1.23–1.61), respectively] 15.…”

Section: Introductionmentioning

confidence: 89%

“…For example, in a pooled analysis of 12 case‐control studies from the Childhood Leukemia International Consortium (CLIC), increased odds of ALL were observed among children who had any pesticide exposure in their homes shortly before conception, during pregnancy, or after birth [odds ratio (OR) = 1.39 (95% Confidence Interval (95% CI): 1.25–1.55), 1.43 (95% CI: 1.32–1.54), and 1.36 (95% CI: 1.23–1.61), respectively] 15. Similarly, a study in Brazil, which is the only case‐control study to assess the association between residential pesticide exposure and childhood leukemia in a Latin American country to date, found that self‐reported maternal contact with pesticides during pregnancy was associated with increased odds of ALL [OR = 2.10 (95% CI: 1.14–3.86)] and acute myeloid leukemia (AML) [OR = 5.01 (95% CI: 1.97–12.7)] in infants (aged 0–11 months) 7. In addition, several studies, including the one conducted in Brazil, have reported exposure‐response relationships between residential insecticide exposure and risk of childhood leukemia 3, 4, 6, 7…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, a study in Brazil, which is the only case‐control study to assess the association between residential pesticide exposure and childhood leukemia in a Latin American country to date, found that self‐reported maternal contact with pesticides during pregnancy was associated with increased odds of ALL [OR = 2.10 (95% CI: 1.14–3.86)] and acute myeloid leukemia (AML) [OR = 5.01 (95% CI: 1.97–12.7)] in infants (aged 0–11 months) 7. In addition, several studies, including the one conducted in Brazil, have reported exposure‐response relationships between residential insecticide exposure and risk of childhood leukemia 3, 4, 6, 7…”

Section: Introductionmentioning

confidence: 99%

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Maternal residential pesticide use and risk of childhood leukemia in Costa Rica

Hyland

Gunier

Metayer

et al. 2018

Intl Journal of Cancer

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Evidence suggests that early‐life exposure to pesticides inside the home may be associated with childhood leukemia, however data from Latin American countries are limited. We examined whether self‐reported maternal residential pesticide use and nearby pesticide applications–before and after child's birth–were associated with acute lymphoblastic leukemia (ALL) in the Costa Rican Childhood Leukemia Study (CRCLS), a population‐based case‐control study (2001‐2003). Cases (n = 251 ALL) were diagnosed between 1995 and 2000 (age <15 years at diagnosis) and were identified through the Costa Rican Cancer Registry and National Children's Hospital. Population controls (n = 577) were drawn from the National Birth Registry. We fitted unconditional logistic regression models adjusted for child sex, birth year, and socioeconomic status to estimate the exposure‐outcome associations and also stratified by child sex. We observed that self‐reported maternal insecticide use inside the home in the year before pregnancy, during pregnancy, and while breastfeeding was associated with increased odds of ALL among boys [adjusted Odds Ratio (aOR) = 1.63 (95% confidence interval [95% CI]: 1.05–2.53), 1.75 (1.13–2.73), and 1.75 (1.12–2.73), respectively. We also found evidence of exposure‐response relationships between more frequent maternal insecticide use inside the home and increased odds of ALL among boys and girls combined. Maternal report of pesticide applications on farms or companies near the home during pregnancy and at any time period were also associated with ALL. Our study in Costa Rica highlights the need for education to minimize pesticide exposures inside and around the home, particularly during pregnancy and breastfeeding.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Maternal residential pesticide use and risk of childhood leukemia in Costa Rica

Hyland

Gunier

Metayer

et al. 2018

Intl Journal of Cancer

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Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: Findings from the childhood leukemia international consortium

Bailey

Fritschi

Infante‐Rivard

et al. 2014

Intl Journal of Cancer

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Maternal occupational pesticide exposure during pregnancy and/or paternal occupational pesticide exposure around conception have been suggested to increase risk of leukemia in the offspring. With a view to providing insight in this area we pooled individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium (CLIC). Occupational data were harmonized to a compatible format. Pooled individual analyses were undertaken using unconditional logistic regression. Using exposure data from mothers of 8,236 cases, and 14,850 controls, and from fathers of 8,169 cases and 14,201 controls the odds ratio (OR) for maternal exposure during pregnancy and the risk of acute lymphoblastic leukemia (ALL) was 1.01 (95% confidence interval (CI) 0.78, 1.30) and for paternal exposure around conception 1.20 (95% 1.06, 1.38). For acute myeloid leukemia (AML), the OR for maternal exposure during pregnancy was 1.94 (CI 1.19, 3.18) and for paternal exposure around conception 0.91 (CI 0.66, 1.24.) based on data from 1,329 case and 12,141 control mothers, and 1,231 case and 11,383 control fathers. Our finding of a significantly increased risk of AML in the offspring with maternal exposure to pesticides during pregnancy is consistent with previous reports. We also found a slight increase in risk of ALL with paternal exposure around conception which appeared to be more evident in children diagnosed at the age of five years or more and those with T cell ALL which raises interesting questions on possible mechanisms.

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