<i>In vitro</i> and <i>in vivo</i> targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy

Melancon, Marites P.; Lü, Wei; Liu, Yang; Zhang, Rui; Cheng, Zhi; Elliot, Andrew; Stafford, Jason; Olson, Tammy Y.; Zhang, Jin Z.; Li, Chun

doi:10.1158/1535-7163.mct-08-0016

Cited by 386 publications

(439 citation statements)

References 31 publications

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“…HGNs are also biocompatible, stable to photodegradation and can be easily functionalized for use in bio-targeting and biodelivery [53,60,[78][79][80]. These particles also possess large surface to volume (S/V) ratios, tunable plasmon resonance, pinholes that act as hot spots to further intensify EM surface energy and, as hollow structures, are known to be more sensitive to the refractive index of their surroundings than their solid counterparts [15,66,[81][82][83][84].…”

Section: Metal Nanostructuresmentioning

confidence: 99%

“…There has been an increasing interest in using HGNs in PTA applications [72,78]. In addition to their small size, spherical shape, biocompatibility, and lack of susceptibility to photobleaching, their extinction peaks can be easily tuned to the NIR [60,78,79,221].…”

Section: Pta With Hgnsmentioning

confidence: 99%

“…In addition to their small size, spherical shape, biocompatibility, and lack of susceptibility to photobleaching, their extinction peaks can be easily tuned to the NIR [60,78,79,221]. Additionally, the enhanced near field energy associated with their surface plasmon resonance and thin shells, which produce high absorption cross-sections, makes them ideal nanostructures for PTA.…”

Section: Pta With Hgnsmentioning

confidence: 99%

“…The first demonstration of HGN viability in PTA was reported in 2008 by Melancon et al [78]. In this work, the authors have attached monoclonal antibody epidermal growth factor receptor (EGFR) to 30 nm HAuNS in order to target the A431 oral cancer cell line both in vitro and in vivo.…”

Section: Pta With Hgnsmentioning

confidence: 99%

“…Selective uptake of the bioconjugated NPs by the tumor cells was demonstrated by imaging scattered light from the HAuNS. Ablation experiments were performed using a diode laser centered at 808 nm with 40 W/cm 2 of power for 5 min [78]. Cells treated with anti-EGFR-HAuNS plus laser selectively destroyed tumor cells, while those exposed to anti-EGFR-HAuNS alone, laser alone, or IgG-HAuNS plus laser did not.…”

Section: Pta With Hgnsmentioning

confidence: 99%

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Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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Section: Metal Nanostructuresmentioning

confidence: 99%

Section: Pta With Hgnsmentioning

confidence: 99%

Section: Pta With Hgnsmentioning

confidence: 99%

Section: Pta With Hgnsmentioning

confidence: 99%

Section: Pta With Hgnsmentioning

confidence: 99%

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Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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Theranostic Applications of Gold Core–Shell Structured Nanoparticles

Lü

Melancon

2011

Nanoplatform‐Based Molecular Imaging

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Gold core-shell nanostructures have unique optical properties due to strong and tunable surface plasmon resonance, which is a collective oscillation of conduction-band electrons within the structures induced by the oscillating dipole of a resonant wavelength of light. By varying the core composition, core radius, and shell thickness, the optical resonances of core-shell nanostructures-including silica-core gold nanoshells, hollow gold nanoshells, and hollow gold nanocages-can be continuously tuned through wavelengths ranging from the ultraviolet region to the infrared region. These novel nanoparticles have been shown to be useful for a variety of potential applications in biomedicine, including cancer molecular optical imaging, controlled drug delivery, and photothermal ablation therapy. In this chapter, we provide an up-to-date summary of the synthesis, characterization, and preclinical evaluation of gold core-shell nanostructures. We also touch upon the development of multifunctional gold core-shell nanoparticles for theranostic applications (i.e., simultaneous treatment and diagnosis) for cancer. INTRODUCTIONTheranostics are agents that have both a treatment and a diagnostic function. The theranostic approach tailors treatment to the individual patient and has the potential to offer improved therapeutic efficacy, reduced side effects, and improved cost effectiveness. Nanotechnology as an enabling technology has attracted much attention in recent years. In particular, multifunctional nanomaterials incorporating both diagnostic and therapeutic functions have been created and evaluated for cancer theranostic applications.Nanomaterials that interact with light provide a unique opportunity [1]. These photocoupling agents can not only report the molecular-specific signatures of cancer with high sensitivity and high spatial resolution but also mediate photochemical, photothermal, and photomechanical responses that can be harnessed to kill cancer cells. Nanoplatform-Based Molecular Imaging Edited by Xiaoyuan Chen

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Cancer Theranostics With Hollow Gold Nanospheres

Lü¹,

Li²

2013

Drug Delivery Applications of Noninvasive Imaging

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In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy

Abstract: Laser-induced phototherapy is a new therapeutic use of electromagnetic radiation for cancer treatment. The use of targeted plasmonic gold nanoparticles can reduce the laser energy necessary for selective tumor cell destruction.

Cited by 386 publications

References 31 publications

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

Theranostic Applications of Gold Core–Shell Structured Nanoparticles

Cancer Theranostics With Hollow Gold Nanospheres

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