<i>In Vitro</i> safety assessment of the ethanolic extract of <i>Kalanchoe pinnata</i> on human peripheral lymphocytes

Saravanan, V.; Murugan, S.; Rajkumar, Jampala; Krishnan, K. R Navaneetha; Prdeepa, P.

doi:10.5958/0974-360x.2018.00480.8

Cited by 2 publications

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“…Globally, around 75% of the population from the developing and developed nations like Britain, Germany, and France use plants and their extracts as a medicine [32]. Out of 150 thousand plants being studied, med-clinically important components have been observed in many of them [33]. Plant derivatives have shown to promote stem cell proliferation and multilineage differentiation.…”

Section: Introductionmentioning

confidence: 99%

A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation

Saud

Malla

Shrestha

2019

Stem Cells International

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Stem cell has immense potential in regenerative cellular therapy. Mesenchymal stem cells (MSCs) can become a potential attractive candidate for therapy due to its remarkable ability of self-renewal and differentiation into three lineages, i.e., ectoderm, mesoderm, and endoderm. Stem cell holds tremendous promises in the field of tissue regeneration and transplantation for disease treatments. Globally, medicinal plants are being used for the treatment and prevention of a variety of diseases. Phytochemicals like naringin, icariin, genistein, and resveratrol obtained from plants have been extensively used in traditional medicine for centuries. Certain bioactive compounds from plants increase the rate of tissue regeneration, differentiation, and immunomodulation. Several studies show that bioactive compounds from plants have a specific role (bioactive mediator) in regulating the rate of cell division and differentiation through complex signal pathways like BMP2, Runx2, and Wnt. The use of plant bioactive phytochemicals may also become promising in treating diseases like osteoporosis, neurodegenerative disorders, and other tissue degenerative disorders. Thus, the present review article is aimed at highlighting the roles and consequences of plant extracts on MSCs proliferation and desired lineage differentiations.

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Section: Introductionmentioning

confidence: 99%

A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation

Saud

Malla

Shrestha

2019

Stem Cells International

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Topical Application of Robusta Coffee Extract Gel Enhances Angiogenesis, Fibroblast, Collagen Density, and Epithelial Thickness on Wound Healing of Skin Graft in Rats

Elfiah,

Kholid,

Safitri

2024

RJPT

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Skin graft is a reconstructive procedure commonly used to cover defects or wounds. The majority of post-skin graft treatments use topical agents or the application of modern dressings. However, these treatments have been considered to have disadvantages, such as being limited and expensive. Abundant natural ingredients can be used as alternatives to aid the healing process, one of which is robusta coffee. Robusta coffee is reported to contain active ingredients such as CGA, flavonoids, and saponins. This study aimed to prove the wound healing effect of robusta coffee extract in gel dosage form on the skin graft model in rats. Thirty male Long Evans rats were divided into three groups: negative control (gel base), positive control (1% kojic acid gel), and 5% robusta coffee extract gel (RCEG). A 2 x 2cm split-thickness skin graft was harvested from the dorsal skin of the rat and then fixed to the split-thickness wound at the donor site. Skin graft tissues were taken by biopsy on days 7, 14, and 21 for histopathological evaluation by assessing angiogenesis, fibroblasts, collagen density, and epithelial thickness. Our results found that the number of blood vessels, fibroblast cell count, collagen density percentage, and epithelial thickness were significantly higher in the 5% RCEG group on days 7, 14, and 21 compared to the control group. In conclusion, topical application of 5% RCEG can enhance wound healing of skin graft by improving angiogenesis, fibroblasts, collagen density, and epithelial thickness.

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In Vitro safety assessment of the ethanolic extract of Kalanchoe pinnata on human peripheral lymphocytes

Cited by 2 publications

References 0 publications

A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation

A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation

Topical Application of Robusta Coffee Extract Gel Enhances Angiogenesis, Fibroblast, Collagen Density, and Epithelial Thickness on Wound Healing of Skin Graft in Rats

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