<i>In vivo</i> dosimetry in brachytherapy

Tanderup, Kari; Beddar, Sam; Andersen, C.E.; Kertzscher, Gustavo; Cygler, Joanna

doi:10.1118/1.4810943

Cited by 161 publications

(133 citation statements)

References 119 publications

(135 reference statements)

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“…It is therefore important to have confidence in the dose that is being delivered and there is increasing interest in performing in-vivo dosimetry (IVD) [3,4]. UK guidelines recommend that IVD is performed for most radiotherapy patients at the beginning of their treatment [5].…”

Section: Introductionmentioning

confidence: 99%

Real-time in vivo dosimetry in high dose rate prostate brachytherapy

Mason¹,

Mamo²,

Al-Qaisieh³

et al. 2016

Radiotherapy and Oncology

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Material and methods IVD was performed for 40 treatments planned using intra-operative trans-rectal ultrasound (TRUS) with a MOSFET inserted into an additional needle. Post-treatment TRUS images were acquired for 20 patients to assess needle movement. Monte Carlo simulations of treatment plans were performed for 10 patients to assess impact of heterogeneities.Per-needle and total plan uncertainties were estimated and retrospectively applied to the measured data as error detection thresholds. ResultsThe mean measured dose was -6.4% compared to prediction (range +5.1% to -15.2%). Needle movement and heterogeneities accounted for -1.8% and -1.6% of this difference respectively (mean values for the patients analysed). Total plan uncertainty (k=2) ranged from 11% to 17% and per needle uncertainty (k=2) ranged from 18% to 110% (mean 31%). One out of 40 plans and 5% of needles were outside k=2 error detection threshold. Conclusions

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Section: Introductionmentioning

confidence: 99%

Real-time in vivo dosimetry in high dose rate prostate brachytherapy

Mason¹,

Mamo²,

Al-Qaisieh³

et al. 2016

Radiotherapy and Oncology

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“…Researchers have summarized the errors and variations in brachytherapy along with their potential for detection by each verification method 21, 22. Not all events can be detected by a single verification method.…”

Section: Discussionmentioning

confidence: 99%

High‐dose rate intracavitary brachytherapy pretreatment dwell position verification using a transparent applicator

Otani

Sumida

Nose

et al. 2018

J Applied Clin Med Phys

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PurposeThe major errors in HDR brachytherapy are related to treatment distance, almost all of which are caused by incorrect applicator information. The aim of this study is to propose a quick pretreatment verification method to evaluate channel length and dwell position with a transparent applicator, which, in addition, is suitable as an education tool to assist in the understanding of the applicator structure.MethodsA transparent applicator model was fabricated using a three‐dimensional printer and transparent resin. Its aim is to be a replica of a real gynecological applicator. The pretreatment verification is performed by observing the planned dwell positions of a check cable inside a transparent applicator. A digital camera acquired images and the dwell positions of the radioactive source and check cable were evaluated by comparing them with respect to the theoretical dwell positions marked by the proper x‐ray marker. The potential effectiveness of verification using a transparent applicator was also evaluated using brachytherapy events reported in the literature.ResultsThe transparent applicator closely resembles the real applicator in shape and had an error of less than 0.2 mm. The average dwell position displacement between the radioactive source and check cable was 0.4 mm. The analysis of brachytherapy events showed that channel‐length, dwell‐position, and step‐size errors made up 50% of all events, but affected 64% of all patients.ConclusionsThe transparent applicator model enables a noninvasive, repeatable verification of the channel length and dwell positions to be performed before treatment. This verification has the potential to help prevent common errors in treatment delivery. In addition, the transparent applicator model can be used as a teaching tool to help clinicians understand the operation of the applicator, lowering the risk of events.

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“…While IVD has been used in brachytherapy (BT) for decades and the initial motivation for performing was mainly to assess doses to organs at risk (OAR) by direct measurements, because precise evaluation of OAR doses was difficult without 3D dose treatment planning. With the introduction of 3D image-guided BT, it is now possible to calculate 3D tumour and OAR doses but IVD is very relevant in BT as an independent method for detection of deviations or errors [5]. Comprehensive guidelines for the implementation of in-vivo dosimetry with diodes are published by ESTRO [6] and AAPM [7].…”

Section: #! 'mentioning

confidence: 99%

Assessment of patient dose in medical processes byin-vivodose measuring devices: A review

Tunçel

2016

EPJ Web Conf.

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"#!# In-vivo dosimetry (IVD) in medicine especially in radiation therapy is a well-established and recommended procedure for the estimation of the dose delivered to a patient during the radiation treatment. It became even more important with the emerging use of new and more complex radiotherapy techniques such as intensity-modulated or image-guided radiation therapy. While IVD has been used in brachytherapy for decades and the initial motivation for performing was mainly to assess doses to organs at risk by direct measurements, it is now possible to calculate 3D for detection of deviations or errors. Invivo dosimeters can be divided into real-time and passive detectors that need some finite time following irradiation for their analysis. They require a calibration against a calibrated ionization chamber in a known radiation field. Most of these detectors have a response that is energy and/or dose rate dependent and consequently require adjustments of the response to account for changes in the actual radiation conditions compared to the calibration situation. Correction factors are therefore necessary to take. Today, the most common dosimeters for patients' dose verification through in-vivo measurements are semiconductor diodes, thermo-luminescent dosimeters, optically stimulated luminescence dosimeters, metal-oxidesemiconductor field-effect transistors and plastic scintillator detectors with small outer diameters.

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In vivo dosimetry in brachytherapy

Cited by 161 publications

References 119 publications

Real-time in vivo dosimetry in high dose rate prostate brachytherapy

Real-time in vivo dosimetry in high dose rate prostate brachytherapy

High‐dose rate intracavitary brachytherapy pretreatment dwell position verification using a transparent applicator

Assessment of patient dose in medical processes byin-vivodose measuring devices: A review

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