<i>Lactobacillus paracasei</i> KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota

Kim, Woon-Ki; Jang, Young-Joo; Han, Dae Hee; Jeon, Kyungchan; Lee, Cheonghoon; Han, Hyuk Seung; Ko, GwangPyo

doi:10.1080/19490976.2020.1819156

Cited by 59 publications

(61 citation statements)

References 56 publications

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“…Potential probiotic genera, such as Dubosiella , Lactobacillus , Bifidobacterium , and Candidatus_Saccharimonas were depleted by APAP treatment, whereas the abundances of Lactobacillus and Candidatus_Saccharimonas were observably reversed by A. muciniphila administration ( 50 , 51 ). Many studies have demonstrated that Lactobacillus can stimulate Treg cell proliferation, promote SCFA production and prevent epithelial barrier dysfunction, exerting immunomodulatory effects ( 52 , 53 ). Importantly, the abundance of Lactobacillus is decreased in a variety of liver diseases, and supplementation with Lactobacillus shows a protective effect against liver damage ( 44 , 45 , 54 , 55 ).…”

Section: Discussionmentioning

confidence: 99%

Akkermansia muciniphila Ameliorates Acetaminophen-Induced Liver Injury by Regulating Gut Microbial Composition and Metabolism

Xia

Liu

et al. 2022

Microbiol Spectr

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Our work revealed that A. muciniphila attenuated APAP-induced liver injury by alleviating oxidative stress and inflammation in the liver, and its hepatoprotective effect was accompanied by activation of the PI3K/Akt pathway and mediated by regulation of the composition and metabolic function of the intestinal microbiota. This finding suggested that the microbial community is a non-negligible impact on drug metabolism and probiotic administration could be a potential therapy for drug-induced liver injury.

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Section: Discussionmentioning

confidence: 99%

Akkermansia muciniphila Ameliorates Acetaminophen-Induced Liver Injury by Regulating Gut Microbial Composition and Metabolism

Xia

Liu

et al. 2022

Microbiol Spectr

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“…Furthermore, Treg differentiation not only regulates Th1/Th2 immune balance but suppresses Th17-biased response. L. paracasei KBL382 significantly improved the pathological features and altered the gut microbial composition in AD mice (114). It regulated immune balance via increasing the expression of IL-10 and transforming growth factor-b and enhancing the differentiation of CD4+ CD25+ Foxp3+ Treg in mesenteric lymph nodes.…”

Section: Regulation Of Probiotics On Immune Responses In Admentioning

confidence: 98%

Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review

et al. 2021

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Atopic dermatitis (AD) is a public health concern and is increasing in prevalence in urban areas. Recent advances in sequencing technology have demonstrated that the development of AD not only associate with the skin microbiome but gut microbiota. Gut microbiota plays an important role in allergic diseases including AD. The hypothesis of the “gut-skin” axis has been proposed and the cross-talk mechanism between them has been gradually demonstrated in the research. Probiotics contribute to the improvement of the intestinal environment, the balance of immune responses, regulation of metabolic activity. Most studies suggest that probiotic supplements may be an alternative for the prevention and treatment of AD. This study aimed to discuss the effects of probiotics on the clinical manifestation of AD based on gut microbial alterations. Here we reviewed the gut microbial alteration in patients with AD, the association between gut microbiota, epidermal barrier, and toll-like receptors, and the interaction of probiotics and gut microbiota. The potential mechanisms of probiotics on alleviating AD via upregulation of epidermal barrier and regulation of immune signaling had been discussed, and their possible effective substances on AD had been explored. This provides the supports for targeting gut microbiota to attenuate AD.

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“…Furthermore, clinical studies also revealed the important role of L. paracasei supplementation in ameliorating inflammation in humans ( 11 , 12 ). Mechanically, L. paracasei can act as a probiotic to improve gut microbial composition ( 13 , 14 ). Increasing evidence has demonstrated that the gut microbiota is highly associated with the host inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus paracasei S16 Alleviates Lumbar Disc Herniation by Modulating Inflammation Response and Gut Microbiota

Wang

Chen

et al. 2021

Front. Nutr.

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Lumbar disc herniation (LDH) is a common cause for low back pain. In this study, we aimed to explore the effects of a specific Lactobacillus paracasei (L. paracasei), L. paracasei S16, on the symptoms of LDH using a mouse model of LDH. The results showed that L. paracasei S16 treatment improved the behavior, increased the cell proliferation, and decreased the apoptosis in LDH mice. Moreover, L. paracasei S16 treatment alleviated the aberrant inflammation response in the LDH mice, which is characterized by the decreased anti-inflammatory cytokines, increased pro-inflammatory cytokines, and decreased percentage of Th1 and Th2 cells and Th17/Treg ratio. 16S rRNA sequencing results showed that the LDH mice treated with L. paracasei S16 have higher relative abundance of Lachnospiraceae and Ruminococcaceae and lower abundance of Lactobacillaceae than mice in the LDH group. Additionally, the serum metabolites involved in the linoleic acid metabolism, alanine. aspartate, and glutamate, glycerophospholipid, and TCA cycle were significantly decreased and the metabolite involved in purine metabolism was significantly increased after the L. paracasei S16 treatment in the LDH mice. These results showed that administration of L. paracasei S16 can improve inflammation response, alter gut microbiota, and modulate serum metabolomics in a mouse model of LDH.

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Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota

Cited by 59 publications

References 56 publications

Akkermansia muciniphila Ameliorates Acetaminophen-Induced Liver Injury by Regulating Gut Microbial Composition and Metabolism

Akkermansia muciniphila Ameliorates Acetaminophen-Induced Liver Injury by Regulating Gut Microbial Composition and Metabolism

Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review

Lactobacillus paracasei S16 Alleviates Lumbar Disc Herniation by Modulating Inflammation Response and Gut Microbiota

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