<i>Lippia origanoides</i>essential oil: an efficient and safe alternative to preserve food, cosmetic and pharmaceutical products

Hernandes, Camila; Pina, Edieidia Souza; Contini, Sílvia Helena Taleb; Bertoni, Bianca Waléria; Cestari, Ivanice Maria; Espanha, Lívia Greghi; Varanda, Eliana A.; Camilo, Katyana França Bonini; Martinez, Edson Zangiacomi; França, Suzelei de Castro; Pereira, Ana Maria Soares

doi:10.1111/jam.13398

Cited by 35 publications

(13 citation statements)

References 48 publications

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“…In contrast, the chemical composition found in the present study was different from that of other publications. Carvacrol, for instance, was the major component found in L. origanoides collected in the city of Jardinópolis (São Paulo, Brazil), with a concentration of 26.28% [ 45 ]. In the essential oil of L. origanoides collected at Embrapa Western Amazon in Manaus (Amazonas, Brazil), the major compound was thymol (76.6%), whereas in L. origanoides collected in the city of Oriximiná (Pará, Brazil), the major compounds were carvacrol (38.6%) and thymol (18.5%) [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition and Antibacterial Activity of the Lippia origanoides Kunth Essential Oil from the Carajás National Forest, Brazil

Ribeiro

Oliveira

Feitosa

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Species of the genus Lippia are rich in essential oils and have shown antibacterial properties, which may be related to oils’ chemical composition. The present work aimed to evaluate the antimicrobial potential of Lippia origanoides Kunth against two bacteria strains: Escherichia coli and Staphylococcus aureus. Leaf essential oils were obtained by hydrodistillation in a modified Clevenger-type apparatus, and their chemical composition was determined by gas chromatography coupled to mass spectrometry (GC/MS) and flame ionization detection (GC/FID). We identified 28 compounds, representing 98.87% of the total concentration of the essential oil. The compounds identified at the highest concentrations were 1,8-cineole (35.04%), carvacrol (11.32%), p-cymene (8.53%), α-pinene (7.17%), and γ-terpinene (7.16%). The leaf essential oil of L. origanoides showed antibacterial action on biological isolates of Escherichia coli and Staphylococcus aureus. For Escherichia coli, the oil presented bactericidal action at concentrations of 5–20 μL/mL. Regarding Staphylococcus aureus, the bactericidal effect was noted at 20 μL/mL and the bacteriostatic action was noted around 2.5–10 μL/mL. Given the results obtained, L. origanoides essential oil showed promising biological potential against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria, thus encouraging further studies on substances isolated from this species to contribute to the development of new antimicrobial drugs.

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Section: Resultsmentioning

confidence: 99%

Chemical Composition and Antibacterial Activity of the Lippia origanoides Kunth Essential Oil from the Carajás National Forest, Brazil

Ribeiro

Oliveira

Feitosa

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…O óleo essencial de alecrim-pimenta (Lippia origanoides) teve boas perspectivas para a indústria tanto farmacêutica como alimentícia. Hernandes et al, (2017)…”

Section: Discussionunclassified

“…afirmou em seu estudo que o óleo essencial de L. origanoides poderia substituir com segurança o uso de conservantes nas diferentes formulações testadas, xarope, suco de laranja e xampu devido sua baixa toxicidade, não alergênico e sem potencial mutagênico(HERNANDES et al, 2017).Um ponto a ser ressaltado, se dá a uma das características organolépticas dos óleos essenciais: o odor forte. Alguns autores(HERNANDES et al, 2017;WIŃSKA et al, 2019) enfatizaram essa problemática por conta de se tratar de uma substãcia natural a concentração inibitória miníma dos óleos essenciais é superior as concentrações comumente utilizadas dos conservantes sintéticos. Sendo assim, ainda é necessário o investimento sobre formas de minimizar ou neutralizar o odor dos óleos essencias para que possam ser adicionados em produtos sem causar impacto nas características organolépticas dos mesmos, uma opção seria o encapsulamento como sugerido por Hernandes et al, (2017) e Winska et al, (2019) devido também a volatilidade dos seus compostos .…”

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Uso de substâncias bioativas como conservantes naturais em formas farmacêuticas: uma revisão / Use of bioactive substances as natural preservatives in pharmaceutical forms: a review

Martelli¹,

Camargo²,

Vieira³

et al. 2021

Braz. J. Hea. Rev.

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Conservantes são substâncias antimicrobianas em sua maioria derivados sintéticos, adicionados em formulações em concentrações baixíssimas, tendo como objetivo aumentar o tempo de validade e de uso do produto. Para evitar o uso de agentes químicos, devido a relatos de reações alérgicas e questões de segurança, o mercado começou a explorar o potencial antimicrobiano de substâncias naturais, óleos essenciais e extratos vegetais como conservante em formas farmacêuticas. Esse trabalho objetiva buscar na literatura o potencial de aplicação de substâncias bioativas como conservantes naturais

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“…Its essential oil has antimicrobial (Oliveira et al 2007) and antifungal activity (Betancur et al 2011). It also presents potential as a natural pest controlling agent (Mar et al 2018), a preservative for food, and use in pharmaceutical and cosmetic products (Hernandes et al 2017).…”

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confidence: 99%

Complete plastid genome of Lippia origanoides (Verbenaceae) and phylogenomic analysis of Lamiales

Sarzi

Haerolde

Lopes

et al. 2019

Mitochondrial DNA Part B

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Lippia origanoides (Kunth), also known as salva-de-maraj o, is an aromatic shrub distributed from central America to northern South America that presents biomedical potential. Here we sequenced a partial genome dataset for salva-de-maraj o using 1/11th of a lane on Illumina Hiseq. The software MIRA was used to assemble the complete plastid using different k-mer sizes and further merging well-assembled regions through manual curation. The plastid genome was 154,310 bp in length, divided in one Large Single Copy region containing 85,156 bp; one Small Single Copy region containing 13,320 bp; and two inverted repeat regions presenting different sizes: IRa, containing 25,955 bp; and IRb, containing 29,879 bp. Genome annotation was automatically performed using GeSeq. Artemis was used to perform manual curation. The plastid presents 88 protein-coding genes, 36 tRNAs and 8 rRNAs. It was deposited in GenBank under the accession number MK248831. Twenty-three species of Lamiales containing complete plastids distributed along nine different families were downloaded to confirm the phylogenetic position of this newly described genome, plus 3 outgroup species. Forty-three genes were found to be present in all plastids. These genes were aligned and concatenated to produce a dataset of 13,959 nucleotidic positions. Modeltest defined the best substitution model as the General Time Reversible. As expected, the phylogenomic analysis grouped L. origanoides together with Aloysia citrodora in a monophyletic clade representing the Verbenaceae family. The complete chloroplast genome of L. origanoides will contribute to support further studies on population genetics, phylogeography, evolutionary, and conservation biology of Verbenaceae.

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Lippia origanoidesessential oil: an efficient and safe alternative to preserve food, cosmetic and pharmaceutical products

Abstract: This study allowed for the complete understanding of the antimicrobial action and toxicological potential of L. origanoides essential oil. These results facilitate the development of a preservative system based on L. origanoides essential oil.

Cited by 35 publications

References 48 publications

Chemical Composition and Antibacterial Activity of the Lippia origanoides Kunth Essential Oil from the Carajás National Forest, Brazil

Chemical Composition and Antibacterial Activity of the Lippia origanoides Kunth Essential Oil from the Carajás National Forest, Brazil

Uso de substâncias bioativas como conservantes naturais em formas farmacêuticas: uma revisão / Use of bioactive substances as natural preservatives in pharmaceutical forms: a review

Complete plastid genome of Lippia origanoides (Verbenaceae) and phylogenomic analysis of Lamiales

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