I. Longitudinal changes in aging brain function

Beason‐Held, Lori L.; Kraut, Michael A.; Resnick, Susan M.

doi:10.1016/j.neurobiolaging.2006.10.031

Cited by 61 publications

(63 citation statements)

References 74 publications

(79 reference statements)

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“…Changes in the patterns of brain activity, including both increased and decreased rCBF, are seen when comparing the older brain to the young brain 12,13 and are observed over time in healthy older subjects as they age. 14,15 In the present study, HTN is associated with greater longitudinal decline in middle and inferior prefrontal regions, the anterior cingulate gyrus, occipitotemporal regions, and in visual association cortices relative to HCs. Our HTN subjects also show regions where blood flow patterns do not indicate relative increases over time to the same extent as HC.…”

Section: Pet Findingssupporting

confidence: 48%

Longitudinal Changes in Cerebral Blood Flow in the Older Hypertensive Brain

Beason‐Held

Moghekar

Zonderman

et al. 2007

Stroke

171

110

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Background and Purpose-Changes in patterns of regional cerebral blood flow (rCBF) were assessed over a period of 6 years in 14 treated hypertensive participants (HTNs) and 14 age-matched healthy older participants (healthy controls [HCs]) in the Baltimore Longitudinal Study of Aging. Methods-Resting-state PET scans collected at years 1, 3, 5, and 7 were used to determine differences in longitudinal patterns of rCBF change in HTNs relative to HCs. Pulse pressure, arterial pressure, systolic/diastolic blood pressure, and hypertension duration were also correlated with patterns of rCBF change in the HTN group. Results-Relative to HCs, the HTN group shows greater rCBF decreases in prefrontal, anterior cingulate, and occipital areas over time, suggesting that these regions are more susceptible to hypertension-related dysfunction with advancing age. The HTN group also fails to show preservation of function over time in motor regions and in the temporal cortex and hippocampus as observed in HC. Although pulse pressure, mean arterial pressure, and systolic and diastolic pressure all correlate similarly with longitudinal rCBF changes, increased duration of hypertension is associated with decreased rCBF in prefrontal and anterior cingulate areas of functional vulnerability observed in the HTN group. Conclusions-These results show that hypertension significantly affects resting brain function in older individuals and suggest that duration of hypertension contributes significantly to the patterns of change over time.

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Section: Pet Findingssupporting

confidence: 48%

Longitudinal Changes in Cerebral Blood Flow in the Older Hypertensive Brain

Beason‐Held

Moghekar

Zonderman

et al. 2007

Stroke

171

110

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“…the older) males. However, this method of calculation does not reflect the fact that absolute or whole-brain values were actually higher in paired and lesioned males than in the lone males (F 2 = 4.99, p = 0.027), an effect that is opposite to that you would expect based on normal changes in brain metabolism with age reported in the human imaging literature (Martin et al, 1991;Takada et al, 1992;Burns and Tyrrell, 1992;Zuendorf et al, 2003;Beason-Held et al, 2006;Kalpouzos et al, 2007).…”

Section: Discussionmentioning

confidence: 78%

Neural correlates of pair-bonding in a monogamous primate

Bales

Mason²,

Catana

et al. 2007

Brain Research

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The neurobiology of social bonding, despite its relevance to human mental health, has been studied primarily in rodents. In this study we used position emission tomography (PET), registered with structural magnetic resonance imaging (MRI) to investigate central glucose uptake in seventeen males of a monogamous primate species, the titi monkey (Callicebus cupreus). Twelve pair-bonded males (including six with a lesion of the prefrontal cortex) and five lone males were scanned. The five lone males were re-scanned 48 hours after pairing with a female. Significant differences in glucose uptake were found between males in long-term pair-bonds and lone males in areas including the nucleus accumbens, ventral pallidum, medial preoptic area, medial amygdala, and the supraoptic nucleus of the hypothalamus. In paired before and after comparisons, males showed significant changes following pairing in the right nucleus accumbens and ventral pallidum but not in other areas. Lesioned males showed significantly higher uptake in the posterior cingulate cortex than all other males. These results indicate some basic similarities between rodents and primates in the formation and maintenance of selective social bonds, but emphasize the importance of studying long-term maintenance in addition to short-term formation of social bonds.

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“…Although cross-sectional studies are easier to carry out, and have contributed most of what we know to date about aging of the brain, they are vulnerable to cohort effects, and longitudinal studies are necessary for identifying the effects of aging within individuals. There have been a few longitudinal studies of brain function in older adults, which have shown decreased task-related activity over time 193 , both decreases and increases, depending on the specific brain region and cognitive demands 194,195 , and a greater decline of activity in older individuals with risk factors for AD 196 . With so few data points it is difficult to come to any strong conclusions about change over time, highlighting the need for these kinds of studies.…”

Section: Discussionmentioning

confidence: 99%

The cognitive neuroscience of ageing

2012

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PrefaceThe availability of neuroimaging technology has spurred a marked increase in the human cognitive neuroscience literature, including the study of cognitive aging. Although there is a growing consensus that the aging brain retains considerable plasticity of function, currently measured primarily by means of functional magnetic resonance imaging, it is less clear how age differences in brain activity relate to cognitive performance. The field also is hampered by the complexity of the aging process itself and the large number of factors that are influenced by age. In this review, current trends and unresolved issues in the cognitive neuroscience of aging are discussed.

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I. Longitudinal changes in aging brain function

Cited by 61 publications

References 74 publications

Longitudinal Changes in Cerebral Blood Flow in the Older Hypertensive Brain

Longitudinal Changes in Cerebral Blood Flow in the Older Hypertensive Brain

Neural correlates of pair-bonding in a monogamous primate

The cognitive neuroscience of ageing

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