Mycobacterium tuberculosisGenotype and Case Notification Rates, Rural Vietnam, 2003–2006

Abstract

Young adults may be introducing Beijing strains.

First Insights into the Phylogenetic Diversity of Mycobacterium tuberculosis in Nepal

“…In contrast to other studies [57], [58] however, we found no evidence for an association between Lineage 2 and age. Our observation may be explained by bacterial factors or genetic host factors.…”

Development and application of single-tube multiplex real-time PCR for lineage classification of Mycobacterium tuberculosis based on large sequence polymorphism in Northeast Thailand

“…The significant association of the Beijing lineage with drug resistant TB, and especially MDR-TB, is in agreement with previous studies [6,31,33e36]. The younger age of TB patients infected with the Beijing lineage also agrees with previous reports [16,33,36,37]. The proportion of TB patients in Northeast Thailand infected with the Beijing lineage in 2013e2014 was 23%.…”

Diversity of Mycobacterium tuberculosis lineages in French Polynesia

“…8 The Beijing lineage is also largely represented in the Western Pacific (South East Asia), with 30% of the isolates in Cambodia 5 and 32.5% in Vietnam. 6 Nevertheless, the detection of one Beijing isolate in French Polynesia is in agreement with the global dissemination of the Beijing lineage of M. tuberculosis, 20 suggesting a need for increased awareness to limit its spread within the populations. One isolate was identified as belonging to the Manu lineage.…”

“…8 Epidemiology is different in the Western Pacific (South East Asian) region in which the predominant lineage is the East AfricaneIndian lineage with 59% of the strains in Cambodia 5 and 50.7% in Vietnam (East AfricaneIndianeVietnam genotype). 6 The East AfricaneIndian lineage also predominates in Australia (28.5% of the isolates). 25 Overall, these results suggest that two M. tuberculosis lineages predominate in the Pacific area, with the EuroeAmerican lineage being the predominant lineage in the PICTs (Melanesia, Micronesia, and Polynesia subregions) and in New Zealand.…”

“…4 Concerning the genetic diversity of M. tuberculosis in the Pacific region, data are principally available for the Western Pacific region. 5,6 Because there are no laboratory tools, very little is known about the molecular epidemiology of M. tuberculosis in the PICTs, except for studies conducted in Kiribati (Micronesia) 7 and Papua New Guinea (Melanesia). 8 Molecular tools have been proven to be useful in obtaining a better understanding of TB epidemiology.…”