N -Nitrosodiethanolamine in Synthetic Cutting Fluids: A Part-Per-Hundred Impurity

Abstract

N-nitrosodiethanolamine has been found to be present at a concentration of 0.02 to 3 percent in several brands of synthetic cutting fluids. Its identity was confirmed by three independent techniques: (i) by measuring the retention times on two different high-performance liquid-chromatography columns, (ii) by dehydration to N-nitrosomorpholine, and (iii) by preparation of the O-methyl ether derivative.

Mortality studies of machining fluid exposure in the automobile industry IV; a case-control study of lung cancer

“…During the 1970s it was discovered that common nitrite and amine additives were combining to form N-nitrosamines (particularly N-nitrosodiethanolamine or NDELA) in synthetic machining fluids [IARC, 1983;Bingham et al, 1980;Fan et al, 1977;Jarvholm et al, 1991a]. These compounds have been found to be potent carcinogens in rats and hamsters, and are readily absorbed through the skin, as well as through the respiratory tract [Bingham et al, 1980;Jarvholm et al, 1991b].…”

Bladder cancer and occupational exposures.

“…PAH are suspected to be carcinogens and have been implicated in several studies linking cancers of the bladder to some occupations (26,(30)(31)(32)(33). Nitrates, which are present as additives in some fluids, react to form nitrosamines (34,35), which are also suspected bladder carcinogens (36). It is therefore of interest to investigate the reported association between cutting fluids and bladder cancer further in an attempt to evaluate the possible roles of PAH and nitrates .…”

Mortality studies of machining fluid exposure in the automobile industry V: A case-control study of pancreatic cancer

“…In 1977, the nitrosamine N-nitrosodiethanolamine (NDELA) was discovered to be a frequent contaminant of synthetic MWF [Fan et al, 1977]. The International Agency for Research on Cancer (IARC) has classified NDELA as a group 2B carcinogen, ''possibly carcinogenic to humans'' [IARC, 1987].…”