N,N-Dialkyl-4-oxoalkanamides fromgem-Dichlorocyclopropyl Ketones

Effects of crystal packing and hydration on the conformation of enniatin B

“…Similarly, 0N = w3(CN-N-C'-C a') -w4(C~-N-C'-C '') + 1800. (1985); (c) Tishchenko, Karaulov & Karimov (1982).…”

“…Some of the observed geometric parameters, particularly the very large out-of-plane angles of the amide and ester bonds (up to 24°), disagreed so much with the empirical force-field predictions that a need for a revision of the X-ray results was indicated. Indeed, such a revision [Tishchenko, Karaulov & Karimov 1982, hereafter referred to as TKK(82)] has been published, and its was gratifying to find a remarkable agreement between the revised conformation and the calculated one, as was pointed out in a note added in proof in LFS(84). However, the revised crystal structure [TKK(82)] was found to be hydrated.…”

Magnesium iodide promoted defluorinative reactions of 2,2-difluorocyclopropyl aryl ketones with aryl imines: A new, general synthesis of 2-alkylideneazetidines

“…Thus, it would be interesting to see whether the dichloro analogues of 4 might well produce better yields in this reaction. In fact, 2,2-dichlorocyclopropyl ketones are even less well known than the difluoro ones, and although they have been observed to undergo ring-opening reactions in the presence of nucleophiles, apparently by elimination-addition mechanisms (Scheme 11) [6,7], no reactions under Lewis acid catalysis have been reported.…”

Internal and external alkali ion complexes of enniatin B: an empirical force field analysis

“…We are grateful to Dr. Dobler for kindly calling our attention to recent crystallographic determinations of free, unhydrated EnB (Dobler, 1981) and of hydrated EnB (EnB• l'/2H20; Tishchenko et al, 1982) that regretably escaped us.…”