<i>POU5F1P1</i>, a putative cancer susceptibility gene, is overexpressed in prostatic carcinoma

Kastler, Sabine; Honold, Lisa; Luedeke, Manuel; Kuefer, Rainer; Möller, Peter; Hoegel, Josef; Vogel, Walther; Maier, Christiane; Assum, Guenter

doi:10.1002/pros.21100

Cited by 55 publications

(48 citation statements)

References 24 publications

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“…These data suggest that the expression of Oct4 and Sox2 may correlate with the genesis and progression of NB. This result is consistent with most previous studies (17,18,21,24,25). However, further research is needed to validate the correlation, and we will carry out further experiments to demonstrate the effects of Oct4 and Sox2 in NB carcinogenesis.…”

Section: Discussionsupporting

confidence: 91%

“…Expression of Oct4 is restricted to pluripotent cells and its level decreases with the onset of differentiation and loss of pluripotency (9,15). In recent studies, Oct4 expression has been detected in various carcinomas including breast, prostate, bladder, head and neck squamous cell carcinomas and lung adenocarcinoma, which correlates with an unfavorable prognosis (16)(17)(18)(19)(20). Oct4 expression was only found in the immature neuroepithelium of high-grade immature teratomas, which indicates that Oct4 may be a promising biomarker for the diagnosis of highly malignant immature teratoma (21).…”

Section: Discussionmentioning

confidence: 99%

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Oct4 and Sox2 are overexpressed in human neuroblastoma and inhibited by chemotherapy

Yang

Zheng

et al. 2012

Oncol Rep

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Abstract. Neuroblastoma (NB) is the most common extracranial solid tumor in childhood and the most frequently diagnosed neoplasm during infancy. Oct4 and Sox2 are essential transcription factors for embryonic development and play key roles in determining the fate of stem cells. In this study, we aimed to investigate the expression of Oct4 and Sox2 in NB tissues, and evaluated their relationship with various clinicopathological parameters. Oct4 and Sox2 expression in 65 samples of NB and paracancerous tissues was examined by real-time PCR. The relationship between Oct4 and Sox2 expression and clinical data was assessed. To detect Oct4 and Sox2 expression at the protein level, western blot analyses and immunohistochemical staining were employed. We found that the expression levels of Oct4 and Sox2 in NB tissues were significantly higher than those in paracancerous tissues (P<0.05). Oct4 and Sox2 expression was significantly correlated to the clinical stage of NB, but not other clinicopathological parameters including patient gender and age, tumor size, location and histological classification. In stage III and IV tumors, Oct4 and Sox2 expression was significantly decreased in the chemotherapy subgroup as compared with that of the non-chemotherapy subgroup (P<0.05). These findings suggest that the expression of Oct4 and Sox2 may correlate with the genesis and progression of NB. In addition, Oct4 and Sox2 expression can be inhibited by chemotherapy.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Oct4 and Sox2 are overexpressed in human neuroblastoma and inhibited by chemotherapy

Yang

Zheng

et al. 2012

Oncol Rep

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“…However, our analysis does not provide further support for a link between MYC mRNA expression and this risk allele. We also measured transcript levels of the class 5 homeobox transcription factor POU5F1P1, the nearest gene to this locus, which was recently shown to encode a functional nuclear transcriptional activator [25], and to be over-expressed in prostatic carcinoma [26]. With our assay we could not establish a significant correlation between POU5F1P1 mRNA expression and the rs13281615 genotype in 1,401 primary breast tumors.…”

Section: Discussionmentioning

confidence: 93%

Correlation of breast cancer susceptibility loci with patient characteristics, metastasis-free survival, and mRNA expression of the nearest genes

Riaz

Berns

Sieuwerts

et al. 2011

Breast Cancer Res Treat

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To understand the biology of low-risk breast cancer alleles, and to investigate whether these loci also contribute to disease progression that was once established, we examined the association of SNPs tagging the low-risk breast cancer loci in or near FGFR2, LSP1, MAP3K1, H19, TOX3, POU5F1P1, MYC, and 2q35, with clinical, pathological characteristics, prognosis, and mRNA expression of the nearest genes. Tumor DNA samples of 2,480 breast cancer patients were available. Out of this cohort, 1,290 patients with lymph-node negative disease who did not receive adjuvant systemic therapy, the SNP status was associated with metastasis-free survival (MFS). In 1,401 patients, the mRNA expression levels of FGFR2, LSP1, MAP3K1, H19, TOX3, POU5F1P1, and MYC were determined and correlated with SNP genotypes. The SNP rs2981582 in FGFR2 was significantly associated with positive ER and PgR status (P < 0.001 and P = 0.003, respectively). No other significant associations with patient or tumor characteristics were observed. Only rs2107425 near H19 was significantly associated with shorter MFS in uni- and multi-variate analysis (HR: 1.53, CI: 1.12-2.08, P = 0.006 and HR: 1.59, CI: 1.16-2.20, P = 0.004, respectively), with the more aggressive minor allele displaying a recessive trait. The minor allele of SNP rs3803662 located near the TOX3 gene was associated with lower mRNA expression of this gene. In conclusion, except for the association of rs13283662 with TOX3 gene expression indicating a tumor suppressor role of TOX3, our findings suggest that breast cancer low-risk loci generally do not affect expression of the nearest gene in breast tumor tissue. Also the prognosis of patients is largely not affected by low-risk breast cancer loci except for the SNP near H19. How, this SNP affects prognosis warrants further study as it does not operate through altering H19 mRNA expression.

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“…Based on their differences in deduced protein products and their different chromosome locations and genomic structures, I propose to describe these two sequences as two individual genes by designating the gene on chromosome 6 Oct4 and the gene on chromosome 8 Oct3. Describing these two sequences as two individual genes is further supported by emerging evidence that some cancer cells gain expression of Oct3 but not Oct4 and that Oct3 plays a role in carcinogenesis [Zhao et al, manuscript in preparation; (71)].…”

Section: Oct Members and Their Tissue Expression Genomic Organizamentioning

confidence: 99%

Octamer-binding transcription factors: genomics and functions

Zhao¹

2013

Front Biosci

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The Octamer-binding proteins (Oct) are a group of highly conserved transcription factors that specifically bind to the octamer motif (ATGCAAAT) and closely related sequences that are found in promoters and enhancers of a wide variety of both ubiquitously expressed and cell type-specific genes. Oct factors belong to the larger family of POU domain factors that are characterized by the presence of a highly conserved bipartite DNA binding domain, consisting of an amino-terminal specific subdomain (POUS) and a carboxyl-terminal homeo-subdomain (POUH). Eleven Oct proteins have been named (Oct1-11), and currently, eight genes encoding Oct proteins (Oct1, Oct2, Oct3/4, Oct6, Oct7, Oct8, Oct9, and Oct11) have been cloned and characterized. Oct1 and Oct2 are widely expressed in adult tissues, while other Oct proteins are much more restricted in their expression patterns. Oct proteins are implicated in crucial and versatile biological events, such as embryogenesis, neurogenesis, immunity, and body glucose and amino acid metabolism. The aberrant expression and null function of Oct proteins have also been linked to various diseases, including deafness, diabetes and cancer. In this review, I will report both the genomic structure and major functions of individual Oct proteins in physiological and pathological processes.

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POU5F1P1, a putative cancer susceptibility gene, is overexpressed in prostatic carcinoma

Abstract: The over-expression of POU5F1P1 in prostatic carcinoma in addition to its genomic location and the putative function of its gene product render POU5F1P1 a good candidate to harbour functional genetic variants which modulate prostatic cancer susceptibility.

Cited by 55 publications

References 24 publications

Oct4 and Sox2 are overexpressed in human neuroblastoma and inhibited by chemotherapy

Oct4 and Sox2 are overexpressed in human neuroblastoma and inhibited by chemotherapy

Correlation of breast cancer susceptibility loci with patient characteristics, metastasis-free survival, and mRNA expression of the nearest genes

Octamer-binding transcription factors: genomics and functions

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