“…Cyclizine (CYC), 1-(diphenylmethyl)-4-methylpiperazine or 1-benzhydryl-4-methylpiperazine [1] is a piperazine derivative that has been effectively used for the prevention and treatment of nausea and vomiting associated with motion sickness [2,3]. The structures of CYC and chlorcyclizine (CLCYC), the internal standard, are shown in Fig.…”